ChemicalBook > CAS DataBase List > Isradipine

Isradipine

Product Name
Isradipine
CAS No.
75695-93-1
Chemical Name
Isradipine
Synonyms
Iomir;Lomir;Presca;CS-139;Prescal;Esradin;Rebfiden;Clivoten;DynaCirc;Dynacrine
CBNumber
CB2268682
Molecular Formula
C19H21N3O5
Formula Weight
371.39
MOL File
75695-93-1.mol
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Isradipine Property

Melting point:
166-1680C
Boiling point:
501.9±60.0 °C(Predicted)
Density 
1.249±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ~26 mg/mL
form 
solid
pka
2.56±0.70(Predicted)
color 
yellow
Merck 
14,5240
BCS Class
2/4
Stability:
Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
HMJIYCCIJYRONP-UHFFFAOYSA-N
CAS DataBase Reference
75695-93-1(CAS DataBase Reference)
NIST Chemistry Reference
Isradipine(75695-93-1)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I6658
Product name
Isradipine
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$212
Updated
2024/03/01
Sigma-Aldrich
Product number
5.08507
Product name
Isradipine - CAS 75695-93-1 - Calbiochem
Purity
A voltage gated calcium channel gating inhibitor of the dihydropyridine class.
Packaging
10MG
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
1354207
Product name
Isradipine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$375
Updated
2024/03/01
TCI Chemical
Product number
I0876
Product name
Isradipine
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$157
Updated
2024/03/01
Alfa Aesar
Product number
J63920
Product name
Isradipine, 98+%
Packaging
10mg
Price
$117.65
Updated
2024/03/01
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Isradipine Chemical Properties,Usage,Production

Description

Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.

Chemical Properties

Yellow Solid

Originator

Sandoz (Switzerland)

Uses

Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

Uses

nonsedating H1-antihistamine

Uses

Dihydropyridine calcium channel blocker. Antihypertensive; antianginal

Definition

ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.

brand name

Dynacirc (Reliant);Prescal.

General Description

Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.

Biological Activity

Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.

Biochem/physiol Actions

L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

storage

Room temperature

References

1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 3) Merck 14:5240

Isradipine Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate Benzofuroxan Methyl 3-aminocrotonate

Preparation Products

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View Lastest Price from Isradipine manufacturers

Shandong Huizhihan Supply Chain Co., Ltd
Product
Isradipine 75695-93-1
Price
US $0.00-0.00/Bottle
Min. Order
1Bottle
Purity
99%
Supply Ability
20000
Release date
2024-11-26
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Isradipine 75695-93-1
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-08
Baoji Guokang Healthchem co.,ltd
Product
Isradipine 75695-93-1
Price
US $158.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000kg
Release date
2021-06-08

75695-93-1, IsradipineRelated Search:

N,N-Dimethylformamide Dimethyl ether Dimethyl fumarate Dimethyl phthalate Dimethyl sebacate Dimethyl sulfoxide Dihydromyrcenol Dimethyl carbonate ETHANE Pranidipine Ebselen Bendamustine Lercanidipine Oxiracetam Elacridar Isradipine Impurity 2（Isradipine EP Impurity B） Benzofuroxan 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID

  • PN-200-110
  • Presca
  • Prescal
  • 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester
  • 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic [chemical name] acid methyl 1-methylethyl ester
  • Dynacrine
  • Iomir
  • Rebfiden
  • 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
  • 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester
  • PN-200-100
  • [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
  • Isradipine
  • CS-139
  • (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester
  • Dynacirc CR
  • PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR;
  • Isradipin
  • Clivoten
  • DynaCirc
  • Esradin
  • Isrodipine
  • Lomir
  • Isradipine Solution, 100ppm
  • 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester
  • Isradipine (200 mg)
  • 3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Isradipine(Dynacirc)
  • Isradipine API
  • 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
  • Isradipine, >=99%
  • 3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di
  • 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER
  • 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER
  • Isradipine&gt
  • Isradipine CRS
  • 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester
  • 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester
  • Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet
  • Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Isradipine USP/EP/BP
  • Isradipine (PN 200-110)
  • IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What are the applications of Isradipine
  • 4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester
  • Isradipine (1354207)
  • Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
  • Isradipine in methanol
  • Isradipine, L-type Ca2+ channel blocker
  • 75695-93-1
  • 75696-93-1
  • 75695-63-1
  • C19H15N3O5D6
  • ALLEGRA
  • Ion Channels
  • Calcium channel
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • API