[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

Product Name: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
CAS No.: 1469284-79-4
Chemical Name: [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
Synonyms: PF-06424439;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439
CBNumber: CB22750426
Molecular Formula: C23H30ClN7O4S
Formula Weight: 536.0468
MOL File: 1469284-79-4.mol

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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Property

storage temp.: room temp
solubility: H2O: soluble10mg/mL, clear
form: powder
color: white to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0233
Product name: PF-06424439
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0233
Product name: PF-06424439
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $476
Updated: 2024/03/01

Cayman Chemical

Product number: 17680
Product name: PF-06424439
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17680
Product name: PF-06424439
Purity: ≥98%
Packaging: 10mg
Price: $151
Updated: 2024/03/01

Cayman Chemical

Product number: 17680
Product name: PF-06424439
Purity: ≥98%
Packaging: 25mg
Price: $321
Updated: 2024/03/01

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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Chemical Properties,Usage,Production

Description

PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC₅₀ = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC₅₀s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.

Uses

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)?inhibitor:

to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
to study its effects on HeLa cells
to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol Actions

PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

storage

Desiccate at RT

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate Suppliers

China 20 United Kingdom 1 United States 5 USA 1 Global 27

Tocris Bioscience

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1469284-79-4, [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonateRelated Search:

PF-06700841 tosylate PF-06650833 PF-05089771 (tosylate) PF-06424439 PF-06447475 PF 3644022 PF 04995274 PF-3084014 PF 573228 PF-06882961 PF-5190457 PF-05212384 PF-04691502 1H-Indole-2-carboxamide, 4-methoxy-N-[(1S)-3-methyl-1-[[[(1S)-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]-3-(phosphonooxy)propyl]amino]carbonyl]butyl]- PF 477736

PF-06424439

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

PF-06424439 methanesulfonate

PF-06424439 >=98% (HPLC)

acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439

(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate

1469284-79-4