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Terazosin

Product Name
Terazosin
CAS No.
63590-64-7
Chemical Name
Terazosin
Synonyms
Urodie;HYTRIN;erazosin;arbonyl)-;Terazosin;terazosine;CID 663211;TERAZOSIN HCL;Vasomet：Vicard;Hytrin：Hytrinex
CBNumber
CB2285511
Molecular Formula
C19H25N5O4
Formula Weight
387.43
MOL File
63590-64-7.mol
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Terazosin Property

Melting point:
281-283°C
Boiling point:
664.5±65.0 °C(Predicted)
Density 
1.332±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
H2O: 25 mg/mL
form 
powder
pka
pKa (0.1N NaOH): 7.1(at 25℃)
color 
white to off-white
Water Solubility 
30.6mg/L(22.5 ºC)
BCS Class
1/3
InChIKey
VCKUSRYTPJJLNI-UHFFFAOYSA-N
CAS DataBase Reference
63590-64-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
TK8044925
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Usbiological
Product number
466982
Product name
Terazosin
Packaging
1mg
Price
$460
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA28036
Product name
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
Packaging
100g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0005881
Product name
TERAZOSIN
Purity
95.00%
Packaging
1G
Price
$693
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
13666
Product name
TerazosinHCl
Packaging
1g
Price
$850
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA28036
Product name
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine hydrochloride
Packaging
5G
Price
$100
Updated
2021/12/16
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Terazosin Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Crystalline Powder

Uses

An α-1-adrenergicblocker related to prazosin.

Uses

Terazosin is used for the same indications as is prazosin; however, it has the advantage of being able to be used once a day.

Uses

An a-1-adrenergicblocker related to prazosin

Definition

ChEBI: Terazosin is a member of quinazolines, a member of piperazines, a member of furans and a primary amino compound. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.

Clinical Use

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)

Synthesis

Terazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)- piperazine (12.2.13), only differs from prazosin in that the furyl radical is replaced with a tetrahydrofuryl radical. It is synthesized in exactly the same manner except using 1-(2-tetrahydrofuroyl)piperazine instead of 1-(2-furoyl)piperazine [48–51].

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid concomitant use.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

Terazosin is metabolised in the liver; one of the metabolites has antihypertensive activity.
Terazosin is excreted in faeces via the bile, and in the urine, as unchanged drug and metabolites.

Terazosin Preparation Products And Raw materials

Raw materials

2-Furoic acid Piperazine Quinazoline 2-Furoyl chloride Terazosin hydrochloride

Preparation Products

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Terazosin Suppliers

Canada 1 China 125 Europe 3 Germany 1 India 3 Switzerland 1 United Kingdom 7 United States 21 Global 162
LGM Pharma
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1-(800)-881-8210
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615-250-9817
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inquiries@lgmpharma.com
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United States
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
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United States
ProdList
4660
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60
Cato Research Chemicals Inc.
Tel
020-81215950 4000-868-328
Email
customer@uwalab.com
Country
United States
ProdList
10404
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58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19881
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
AlliChem, LLC
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sales@allichemllc.com
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Waterstone Technology, LLC
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MedChemExpress
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Riedel-de Haen AG
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Fragmenta
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ACIC Fine Chemicals Inc.
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Ryan Scientific, Inc.
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2A PharmaChem USA
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HONEST JOY HOLDINGS LIMITED
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Advance Scientific & Chemical
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3B Scientific Corporation
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AK Scientific, Inc.
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Wintersun Chemical
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Lab Express
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Beta Pharma, Inc.
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sales@betapharma.com
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View Lastest Price from Terazosin manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Terazosin 63590-64-7
Price
US $999.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-23
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Terazosin 63590-64-7
Price
US $19.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
20KG
Release date
2022-01-10
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Terazosin 63590-64-7
Price
US $15.60/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000tons
Release date
2022-01-12

63590-64-7, TerazosinRelated Search:

Piperacillin Dimethyldimethoxysilane N-Aminoethylpiperazine Tris(hydroxymethyl)aminomethane 6-Aminocaproic acid Diphenyldimethoxysilane CARBONYL SULFIDE Glycine 3-Aminophenol ALTRENOGEST 1,1-Dimethoxyethane PYRAZOPHOS Terazosin hydrochloride TERAZOSIN RELATED COMPOUND C (25 MG) (1,4-BIS(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)PIPER-AZINE DIHYDROCHLORIDE) TERAZOSIN RELATED COMPOUND B (50 MG) (1-(4-HYDROXY-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-[(TETRA-HYDRO-2-FURANYL)CARBONYL]PIPERAZINE) Terazosin hydrochloride dihydrate 2-chloro-4-amino-6,7-dimethoxyquinazoline (intermediate of terazosin) Quinazoline

  • 1-(4-aMino-6,7-diMethoxy-quinazolin-2-yl)-4-(tetrahydrofuran-2-carbonyl)-piperazine
  • TERAZOSIN(HYTRIN)
  • Prazosin Tetrahydro IMpurity
  • Hytrin：Hytrinex
  • Urodie
  • Vasomet：Vicard
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl) carbonxyl] piperazine hydrochloride
  • 1-(4-Amino-6，7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbowl]piperazine
  • Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-<br />
  • 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(tetrahydrofuran-2-yl)carbonyl]piperazine
  • [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-[(2S)-2-oxolanyl]methanone
  • Methanone,[4-(4-aMino-6,7-diMethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)-
  • [4-(4-AMINO-6,7-DIMETHOXY-QUINAZOLIN-2-YL)PIPERAZIN-1-YL]-OXOLAN-2-YL-METHANONE
  • 1-(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLINYL)-4-[(TETRAHYDRO-2-FURANYL)CARBONXYL]PIPERAZINE, HYDROCHLORIDE
  • HYTRIN
  • TERAZOSIN MONOHYDROCHLORIDE
  • TERAZOSIN HCL
  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)p
  • arbonyl)-
  • terazosine
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine
  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]- (9CI)
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine
  • 6,7-Dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine hydrochloride
  • Terazosin
  • N-(2-tertrahydrofuroyl)-piperazine
  • erazosin
  • Terazosin USP/EP/BP
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-{(tetnaphydro-2-furanyl)carbonyl}piperazine
  • CID 663211
  • 63590-64-7
  • C19H29ClN5O6
  • C19H26ClN5O4
  • C19H28ClN5O6
  • C19H25N5O4
  • API's
  • API
  • Terazosin
  • Intermediates & Fine Chemicals
  • Pharmaceuticals