ALPHA2-MACROGLOBULIN
Description Source Background- Product Name
- ALPHA2-MACROGLOBULIN
- CAS No.
- 95568-41-5
- Chemical Name
- ALPHA2-MACROGLOBULIN
- Synonyms
- A2M;A2MD;CPAMD5;FWP007;S863-7;ALPHA2M;ALPHA2MG;A-2-M, HUMAN;ALPHA2 M, HUMAN;HUMAN ALPHA-2-M
- CBNumber
- CB2306346
- Formula Weight
- 0
- MOL File
- Mol file
ALPHA2-MACROGLOBULIN Property
- storage temp.
- −20°C
- solubility
- H2O: 5 mg/mL, clear to faintly turbid, colorless to faintly yellow
- form
- lyophilized powder
- biological source
- human plasma
- Water Solubility
- water: soluble 10mg protein/mL, clear, colorless
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M6159
- Product name
- α<SUB>2</SUB>-Macroglobulin from human plasma
- Purity
- BioUltra, ≥98% (SDS-PAGE)
- Packaging
- 1 mg
- Price
- $314
- Updated
- 2025/07/31
- Product number
- M6159
- Product name
- α<SUB>2</SUB>-Macroglobulin from human plasma
- Purity
- BioUltra, ≥98% (SDS-PAGE)
- Packaging
- 5 mg
- Price
- $1080
- Updated
- 2025/07/31
- Product number
- M6159
- Product name
- α<SUB>2</SUB>-Macroglobulin from human plasma
- Purity
- BioUltra, ≥98% (SDS-PAGE)
- Packaging
- 10 mg
- Price
- $1870
- Updated
- 2025/07/31
- Product number
- M6159
- Product name
- α2-Macroglobulin from human plasma
- Purity
- BioUltra, ≥98% (SDS-PAGE)
- Packaging
- 1MG
- Price
- $289
- Updated
- 2023/06/20
- Product number
- M6159
- Product name
- α2-Macroglobulin from human plasma
- Purity
- BioUltra, ≥98% (SDS-PAGE)
- Packaging
- 5MG
- Price
- $989
- Updated
- 2023/06/20
ALPHA2-MACROGLOBULIN Chemical Properties,Usage,Production
Uses
α2-Macroglobulin was used to study impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β which is an early biomarker for mild cognitive impairment preceding Alzheimer′s disease. It was also used in the control of the classical and the MBL pathway of complement activation.
Biochem/physiol Actions
α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.
Description
Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa.
Source
Human Plasma
Background
Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.
ALPHA2-MACROGLOBULIN Preparation Products And Raw materials
Raw materials
Preparation Products
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