Flavor Type Chemical Properties Uses
ChemicalBook > CAS DataBase List > 4-Pyridinecarboxaldehyde

4-Pyridinecarboxaldehyde

Flavor Type Chemical Properties Uses
Product Name
4-Pyridinecarboxaldehyde
CAS No.
872-85-5
Chemical Name
4-Pyridinecarboxaldehyde
Synonyms
ISONICOTINALDEHYDE;PYRIDINE-4-CARBALDEHYDE;PYRIDINE-4-CARBOXALDEHYDE;4-PYRIDINECARBALDEHYDE;PYRIDINE-4-ALDEHYDE;4-pyrdine aldehyde;Isonicotinic aldehyde;4-PyridineCarboxyaldehyde;Pyridin-4-al;4-Formylpyrdine
CBNumber
CB2315397
Molecular Formula
C6H5NO
Formula Weight
107.11
MOL File
872-85-5.mol
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4-Pyridinecarboxaldehyde Property

Melting point:
-4--2°C
Boiling point:
71-73 °C/10 mmHg (lit.)
Density 
1.137 g/mL at 20 °C (lit.)
vapor pressure 
0.02 hPa (20 °C)
refractive index 
n20/D 1.544(lit.)
Flash point:
130 °F
storage temp. 
Store at +2°C to +8°C.
solubility 
20g/l
pka
12.05(at 30℃)
form 
liquid (clear)
color 
clear brown-yellow
PH
7-8 (H2O, 20℃)(saturated aqueous solution)
Water Solubility 
20 g/L (20 ºC)
Sensitive 
Air Sensitive
BRN 
105342
InChIKey
BGUWFUQJCDRPTL-UHFFFAOYSA-N
LogP
0.12 at 30℃ and pH7
CAS DataBase Reference
872-85-5(CAS DataBase Reference)
NIST Chemistry Reference
4-Pyridinecarboxaldehyde(872-85-5)
EPA Substance Registry System
4-Pyridinecarboxaldehyde (872-85-5)
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Safety

Hazard Codes 
Xi,F
Risk Statements 
36/37/38-10
Safety Statements 
26-36-36/37/39-16
RIDADR 
UN 1989
WGK Germany 
1
RTECS 
NR9400000
F 
8-10-23
Hazard Note 
Irritant/Keep Cold/Air Sensitive
TSCA 
Yes
HazardClass 
3.2
PackingGroup 
III
HS Code 
29333999
Toxicity
LD50 orally in Rabbit: 2355 mg/kg LD50 dermal Rat > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P62402
Product name
4-Pyridinecarboxaldehyde
Purity
97%
Packaging
25g
Price
$67.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P62402
Product name
4-Pyridinecarboxaldehyde
Purity
97%
Packaging
100g
Price
$245
Updated
2024/03/01
TCI Chemical
Product number
I0143
Product name
4-Pyridinecarboxaldehyde
Purity
>96.0%(GC)
Packaging
25mL
Price
$43
Updated
2024/03/01
TCI Chemical
Product number
I0143
Product name
4-Pyridinecarboxaldehyde
Purity
>96.0%(GC)
Packaging
500mL
Price
$581
Updated
2021/12/16
Alfa Aesar
Product number
A10656
Product name
Pyridine-4-carboxaldehyde, 97%
Packaging
25g
Price
$44.4
Updated
2024/03/01
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4-Pyridinecarboxaldehyde Chemical Properties,Usage,Production

Flavor Type

Flavor Type: fruity

Chemical Properties

4-Pyridinecarboxaldehyde(4PCA) is a slightly yellow oily liquid. Its relative density is 1.122, and its refractive index is 1.5352 (25°C). Flash point is 54 ° C. 4-Pyridinecarboxaldehyde is soluble in water and ether.4-Pyridinecarboxaldehyde, also commonly called pyridine-2-carboxaldehyde, is an organic compound with the formula NC5H4CHO. 4-Pyridinecarboxaldehyde is a colorless oily liquid with a distinctive odor. Older samples are often brown-colored owing to impurities.

Uses

4-Pyridinecarboxaldehyde is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.4-Pyridinecarboxaldehyde and some of its derivatives have also been reported as useful transamination reagents to introduce ketone or aldehyde groups onto the N-termini of antibodies for subsequent site-specifically conjugate aminooxy-functionalized molecules (including fluorescent dyes, polyethylene glycol, or porphyrins) to these entities.
4-Pyridinecarboxaldehyde can be used for the synthesis of: β-Unsaturated amides by coupling with N,N-disubstituted formamides; meso-Substituted A3-corroles; N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs); 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents; 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.

Chemical Properties

clear yellow-brown liquid. soluble in water and ether.

Uses

4-Pyridinecarboxaldehyde, is an heterocyclic building block used for the synthesis of various pharmaceutical compounds, such as new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, having anticonvulsant and anti-inflammatory properties.

Uses

4-Pyridinecarboxaldehyde can be used for the synthesis of:

  • ?,β-Unsaturated amides by coupling with N,N-disubstituted formamides.
  • meso-Substituted A3-corroles.
  • N-(4-pyridylmethyl)-L-valine as a ligand to construct zinc metal–organic frameworks (Zn-MOFs).
  • 4′-Pyridyl terpyridines, with potential application as anticancer and antimicrobial agents.
  • 4-pyridinecarboxaldehyde thiosemicarbazone, as a corrosion inhibitor for mild steel.

Preparation

4-Pyridinecarbaldehyde is synthesized by oxidation of 4-picoline. The mixed gas of 4-picoline and air is passed through the vanadium-molybdenum catalyst layer heated to 400°C, and oxidized to generate 4-pyridinecarbaldehyde.

Synthesis Reference(s)

Synthetic Communications, 20, p. 3385, 1990 DOI: 10.1080/00397919008051576

Purification Methods

Purified as for pyridine-2-aldehyde. [Beilstein 21 III/IV 2529, 21/7 V 351.]

4-Pyridinecarboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

4,4'-Vinylenedipyridine 1-(4-PYRIDYLMETHYL)PIPERAZINE PYRIDIN-4-YLMETHYL-HYDRAZINE 4-Pyridinealdoxime
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View Lastest Price from 4-Pyridinecarboxaldehyde manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
4-Pyridinecarboxaldehyde 872-85-5
Price
US $6.00-5.00/kg
Min. Order
1kg
Purity
95%
Supply Ability
1000kg
Release date
2024-05-13
Hebei Weibang Biotechnology Co., Ltd
Product
4-Pyridinecarboxaldehyde 872-85-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Pyridinecarboxaldehyde 872-85-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-21

872-85-5, 4-PyridinecarboxaldehydeRelated Search:

Donepezil Hydrochloride METHYL ISONICOTINATE Pyridine Chromium picolinate Sulfasalazine 4-Dimethylaminopyridine 4-Methylpyridine Ethyl isonicotinate Isonicotinic acid 4-Pyridoxic acid Isoniazid Pyridine-4-carboxylic acid N-oxide 4-(4-CHLOROBENZOYL)PYRIDINE Pyridoxal 5'-phosphate monohydrate QUINOLINE-4-CARBOXYLIC ACID Isonicotinamide CINCHOPHEN 2-Pyridinecarboxaldehyde

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