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ML329

Product Name
ML329
CAS No.
19992-50-8
Chemical Name
ML329
Synonyms
ML329;ML329;ML 329;ML-329,ML329,ML 329,Inhibitor,inhibit;4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide;4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide;Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
CBNumber
CB23171697
Molecular Formula
C16H12N2O4S
Formula Weight
328.34
MOL File
19992-50-8.mol
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ML329 Property

storage temp. 
2-8°C(protect from light)
solubility 
DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.1 mg/ml
form 
A crystalline solid
color 
White to off-white
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Safety

HS Code 
2935909099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22481
Product name
ML-329
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
22481
Product name
ML-329
Purity
≥98%
Packaging
5mg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
22481
Product name
ML-329
Purity
≥98%
Packaging
10mg
Price
$257
Updated
2024/03/01
Axon Medchem
Product number
Axon2733
Product name
ML329-CID12387471
Purity
99%
Packaging
50mg
Price
$401.5
Updated
2021/12/16
Axon Medchem
Product number
Axon2733
Product name
ML329-CID12387471
Purity
99%
Packaging
10mg
Price
$115.5
Updated
2021/12/16
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ML329 Chemical Properties,Usage,Production

Definition

ChEBI: 4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide is a member of 1,4-naphthoquinones.

Biological Activity

ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor that inhibits TRPM-1 promoter activity with IC50 of 1.2 μM.

in vitro

ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. It could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with it will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. It shows specific activity against the MITF -dependent cells, primary melanocytes but no effect on the viability in A375 cells. It reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. As a tool compound, it will be useful in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

target

TargetValue
MITF
()
TRPM-1 promoter < br/> (Cell-free assay) 1.2 μM

ML329 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML329 Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69

19992-50-8, ML329Related Search:


  • ML329
  • ML329;ML 329
  • Benzenesulfonamide, 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-
  • 4-((1,4-Dioxo-1,4-dihydronaphthalen-2-yl)amino)benzenesulfonamide
  • ML-329,ML329,ML 329,Inhibitor,inhibit
  • 4-[(1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-benzenesulfonamide
  • 19992-50-8