3-TROPANYL-3,5-DICHLOROBENZOATE

Product Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
CAS No.: 40796-97-2
Chemical Name: 3-TROPANYL-3,5-DICHLOROBENZOATE
Synonyms: MDL-72222;MLD-72222;bemesetron;Benesetron;Bemesetron (MDL 72222);tropyl3,5-dichlorobenzoate;MNJNPLVXBISNSX-WDNDVIMCSA-N;tropine 3,5-dichlorobenzoate;TROPANYL 3,5-DICHLOROBENZOATE;3-TROPANYL-3,5-DICHLOROBENZOATE
CBNumber: CB2317210
Molecular Formula: C15H17Cl2NO2
Formula Weight: 314.21
MOL File: 40796-97-2.mol

More

Less

3-TROPANYL-3,5-DICHLOROBENZOATE Property

Melting point:: 165 °C
Boiling point:: 406.5±45.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: 0.1 M HCl: slightly soluble
pka: 9.89±0.40(Predicted)
form: solid
color: white
Water Solubility: Soluble to 100 mM in DMSO. Insoluble in water. Sparingly soluble in chloroform, and ethanol.

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 36
WGK Germany: 3
RTECS: DG7580000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Alfa Aesar

Product number: J62583
Product name: 3-Tropanyl-3,5-dichlorobenzoate, 99+%
Packaging: 50mg
Price: $247
Updated: 2021/12/16

Tocris

Product number: 0640
Product name: MDL72222
Purity: ≥99%(HPLC)
Packaging: 50
Price: $149
Updated: 2021/12/16

TRC

Product number: M199805
Product name: MDL-72222
Packaging: 100mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: 255769
Product name: MDL 72222
Packaging: 50mg
Price: $389
Updated: 2021/12/16

ApexBio Technology

Product number: B6389
Product name: MDL72222
Packaging: 10mg
Price: $189
Updated: 2021/12/16

More

Less

3-TROPANYL-3,5-DICHLOROBENZOATE Chemical Properties,Usage,Production

Originator

Bemesetron,Merrel Dow

Uses

Anti-emetic.

Uses

It is most often used to study the role of SR-3. Studies suggest the blockade of SR-3 with may ameliorate beta-amyloid protein-induced neurotoxicity by interfering with the increase of Ca2+, and then by inhibiting glutamate release, generation of reactive oxygen species and caspase-3 activity. It is also used in the study of dopamine elevation in rats due to cocaine and amphetamine consumption.

Manufacturing Process

Tropine (34.24 g) is treated with anhydrous diethyl ether and ethereal hydrogen chloride and the precipitated hydrochloride is isolated by evaporation of the solvent. 3,5-Dichlorobenzoylchloride (51.7 g) is added and the mixture stirred at 140°C for 15 minutes during which time the mixture liquifies, evolves hydrogen chloride gas and resolidifies. After heating for a further 15 minutes the cooled solid is dissolved in water, an excess of an aqueous solution of potassium carbonate is added, and the base is extracted with ethyl acetate. Evaporation of the dried ethyl acetate solution yields a solid, which is recrystallized from aqueous methanol to yield 3,5- dichlorobenzoic acid 8-methyl-8-aza-bicyclo[3.2.1]oct-1-yl ester (endo). MP: 95°C (51.8 g).

Therapeutic Function

Serotonin antagonist

Biological Activity

5-HT 3 antagonist.

storage

Store at RT

3-TROPANYL-3,5-DICHLOROBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-TROPANYL-3,5-DICHLOROBENZOATE Suppliers

China 47 Europe 2 Germany 2 Switzerland 1 United Kingdom 4 United States 12 USA 1 Global 69

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

BIOMOL INTERNATIONAL, LP

Tel: --
Fax: --
Email: info@biomol.com
Country: United States
ProdList: 1499
Advantage: 77

MP Biomedicals, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6561
Advantage: 81

40796-97-2, 3-TROPANYL-3,5-DICHLOROBENZOATERelated Search:

Palonosetron ALOSETRON dolasetron Dolasetron mesylate Granisetron Palonosetron Hydrochloride Palonosetron Ondansetron hydrochloride ONDANSETRON FOR LC SYSTEM SUITABILITY Agelongine Anpirtoline hydrochloride 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine hydrochloride Tropine 3-TROPANYL-3,5-DICHLOROBENZOATE Nortropine hydrochloride ENDO-TROPACOCAINE (8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL) BENZOATE HCL 4-BENZYLOXY-PIPERIDINE HYDROCHLORIDE

3-TROPANYL-3,5-DICHLOROBENZOATE

MDL-72222

TROPANYL 3,5-DICHLOROBENZOATE

3,5-dichloro-,8-methyl-8-azabicyclo(3.2.1)oct-3-ylester,endo-benzoicaci

Bemesetron (Synonyms: MDL 72222)

Bemesetron (MDL 72222)

3,5-dichloro-benzoicaci(3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yles

bemesetron

endo-8-methyl-8-azabicyclo(3.2.1)oct-3-yl3,5-dichlorobenzoate

tropyl3,5-dichlorobenzoate

tropine 3,5-dichlorobenzoate

(1β,5β)-Tropane-3α-ol 3,5-dichlorobenzoate

3,5-Dichlorobenzoic acid (1β,5β)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl ester

Benesetron

MLD-72222

MNJNPLVXBISNSX-WDNDVIMCSA-N

(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

Benzoic acid, 3,5-dichloro-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Endo-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

rel-(1R,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3,5-dichlorobenzoate

40796-97-2

C15H17Cl2NO2

Analytical Standards

Analytical Chromatography Product Catalog

Forensic and Veterinary Standards

Drug Standards

Chromatography

Serotonin receptor