3-Nitrophenacylbromide
- Product Name
- 3-Nitrophenacylbromide
- CAS No.
- 2227-64-7
- Chemical Name
- 3-Nitrophenacylbromide
- Synonyms
- 2-BroMo-3&priMe;AKOS BBS-00003963;3-Nitrophenacylbromid;LABOTEST-BB LT00233190;3-NITROPHENACYL BROMIDE;M-NITROPHENACYL BROMIDE;3'-NITROPHENACYL BROMIDE;a-Bromo-3itroacetophenone;-Bromo-3-nltroacetopheone;-Bromo-3-nitroacetophenone
- CBNumber
- CB2319971
- Molecular Formula
- C8H6BrNO3
- Formula Weight
- 244.04
- MOL File
- 2227-64-7.mol
3-Nitrophenacylbromide Property
- Melting point:
- 90-96 °C(lit.)
- Boiling point:
- 288.6±15.0 °C(Predicted)
- Density
- 1.8033 (rough estimate)
- refractive index
- 1.6090 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in methanol.
- form
- Crystalline Powder
- color
- Beige-orange to yellow-green
- BRN
- 610594
- CAS DataBase Reference
- 2227-64-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Bromo-3'-nitroacetophenone(2227-64-7)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-27-28-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 344214
- Product name
- 2-Bromo-3′-nitroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $42.56
- Updated
- 2025/07/31
- Product number
- 344214
- Product name
- 2-Bromo-3′-nitroacetophenone
- Purity
- 97%
- Packaging
- 25g
- Price
- $141
- Updated
- 2023/06/20
- Product number
- B2855
- Product name
- 2-Bromo-3'-nitroacetophenone
- Packaging
- 5G
- Price
- $37
- Updated
- 2025/07/31
- Product number
- B2855
- Product name
- 2-Bromo-3'-nitroacetophenone
- Packaging
- 25G
- Price
- $110
- Updated
- 2025/07/31
- Product number
- B688085
- Product name
- 2-Bromo-3''-nitroacetophenone
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
3-Nitrophenacylbromide Chemical Properties,Usage,Production
Chemical Properties
beige-orange to yellow-green crystalline powder
Uses
2-Bromo-3′-nitroacetophenone may be used in the preparation of 2-bromo-3′-nitroacetophenone. It may be used in the preparation of 2-hydroxy-ethyl-1-[(3-nitro-phenyl)-2-oxoethyl]-piperidinium bromide.
General Description
Debromination of 2-bromo-3′-nitroacetophenone in various solvents has been reported.
Synthesis
121-89-1
2227-64-7
The general procedure for the synthesis of 2-bromo-3'-nitroacetophenone from m-nitroacetophenone is as follows: preparation of 2-bromo-1-(3-nitrophenyl)acetophenone (2a-1). Aluminum chloride (0.16 g, 1.20 mmol) was added to a suspension of commercially available 3-nitroacetophenone (4.82 g, 29.19 mmol) in anhydrous ether (25 mL). The reaction mixture was cooled to 0 °C, followed by the slow dropwise addition of bromine (1.50 mL, 29.19 mmol). The reaction mixture was stirred at room temperature for 1 h until complete conversion of the feedstock (monitored by 1H NMR) and the reaction was quenched quickly to avoid dibromide formation. After addition of water (30 mL), the mixture was extracted with ether (3 x 30 mL) and dried over anhydrous magnesium sulfate to afford compound 2a-1 as a yellow-brown solid (5.73 g, 97% yield).1H NMR (CDCl3, 200 MHz): δ 4.50 (s, 2H, H1), 7.73 (t, J = 8.0 Hz, 1H, H7), 8.31 ( ddd, J = 7.8, 1.7, 1.1 Hz, 1H, H8), 8.43 (ddd, J = 8.2, 2.3, 1.1 Hz, 1H, H6), 8.76 (t, J = 1.9 Hz, 1H, H4).13C NMR (CDCl3, 200 MHz): δ 30.4, 123.9, 128.2, 130.4, 134.6, 135.2, 148.6, 189.5. MS-ESI (m/z): [M + H]+ = 244.9.
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 18, p. 8276 - 8292
[2] Patent: WO2017/17004, 2017, A1. Location in patent: Page/Page column 17
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 10, p. 2192 - 2196
[4] Tetrahedron Letters, 2011, vol. 52, # 31, p. 4026 - 4029
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 10, p. 1424 - 1430
3-Nitrophenacylbromide Preparation Products And Raw materials
Raw materials
Preparation Products
3-Nitrophenacylbromide Suppliers
- Tel
- --
- Fax
- --
- info@acros.com
- Country
- Belgium
- ProdList
- 6772
- Advantage
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View Lastest Price from 3-Nitrophenacylbromide manufacturers
- Product
- 3-Nitrophenacylbromide 2227-64-7
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16
- Product
- 3-Nitrophenacylbromide 2227-64-7
- Price
- US $0.00-0.00/drums
- Min. Order
- 1drums
- Purity
- 99%min.
- Supply Ability
- 10tons
- Release date
- 2023-10-22
- Product
- 3-Nitrophenacylbromide 2227-64-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24