ChemicalBook > CAS DataBase List > 3-Nitrophenacylbromide

3-Nitrophenacylbromide

Product Name: 3-Nitrophenacylbromide
CAS No.: 2227-64-7
Chemical Name: 3-Nitrophenacylbromide
Synonyms: 2-BroMo-3&priMe;AKOS BBS-00003963;3-Nitrophenacylbromid;LABOTEST-BB LT00233190;3-NITROPHENACYL BROMIDE;M-NITROPHENACYL BROMIDE;3'-NITROPHENACYL BROMIDE;a-Bromo-3itroacetophenone;-Bromo-3-nltroacetopheone;-Bromo-3-nitroacetophenone
CBNumber: CB2319971
Molecular Formula: C8H6BrNO3
Formula Weight: 244.04
MOL File: 2227-64-7.mol

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3-Nitrophenacylbromide Property

Melting point:: 90-96 °C(lit.)
Boiling point:: 288.6±15.0 °C(Predicted)
Density: 1.8033 (rough estimate)
refractive index: 1.6090 (estimate)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in methanol.
form: Crystalline Powder
color: Beige-orange to yellow-green
BRN: 610594
CAS DataBase Reference: 2227-64-7(CAS DataBase Reference)
NIST Chemistry Reference: 2-Bromo-3'-nitroacetophenone(2227-64-7)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-27-28-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: III
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 344214
Product name: 2-Bromo-3′-nitroacetophenone
Purity: 97%
Packaging: 5g
Price: $42.56
Updated: 2025/07/31

Sigma-Aldrich

Product number: 344214
Product name: 2-Bromo-3′-nitroacetophenone
Purity: 97%
Packaging: 25g
Price: $141
Updated: 2023/06/20

TCI Chemical

Product number: B2855
Product name: 2-Bromo-3'-nitroacetophenone
Packaging: 5G
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B2855
Product name: 2-Bromo-3'-nitroacetophenone
Packaging: 25G
Price: $110
Updated: 2025/07/31

TRC

Product number: B688085
Product name: 2-Bromo-3''-nitroacetophenone
Packaging: 5g
Price: $80
Updated: 2021/12/16

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3-Nitrophenacylbromide Chemical Properties,Usage,Production

Chemical Properties

beige-orange to yellow-green crystalline powder

Uses

2-Bromo-3′-nitroacetophenone may be used in the preparation of 2-bromo-3′-nitroacetophenone. It may be used in the preparation of 2-hydroxy-ethyl-1-[(3-nitro-phenyl)-2-oxoethyl]-piperidinium bromide.

General Description

Debromination of 2-bromo-3′-nitroacetophenone in various solvents has been reported.

Synthesis

121-89-1

2227-64-7

The general procedure for the synthesis of 2-bromo-3'-nitroacetophenone from m-nitroacetophenone is as follows: preparation of 2-bromo-1-(3-nitrophenyl)acetophenone (2a-1). Aluminum chloride (0.16 g, 1.20 mmol) was added to a suspension of commercially available 3-nitroacetophenone (4.82 g, 29.19 mmol) in anhydrous ether (25 mL). The reaction mixture was cooled to 0 °C, followed by the slow dropwise addition of bromine (1.50 mL, 29.19 mmol). The reaction mixture was stirred at room temperature for 1 h until complete conversion of the feedstock (monitored by 1H NMR) and the reaction was quenched quickly to avoid dibromide formation. After addition of water (30 mL), the mixture was extracted with ether (3 x 30 mL) and dried over anhydrous magnesium sulfate to afford compound 2a-1 as a yellow-brown solid (5.73 g, 97% yield).1H NMR (CDCl3, 200 MHz): δ 4.50 (s, 2H, H1), 7.73 (t, J = 8.0 Hz, 1H, H7), 8.31 ( ddd, J = 7.8, 1.7, 1.1 Hz, 1H, H8), 8.43 (ddd, J = 8.2, 2.3, 1.1 Hz, 1H, H6), 8.76 (t, J = 1.9 Hz, 1H, H4).13C NMR (CDCl3, 200 MHz): δ 30.4, 123.9, 128.2, 130.4, 134.6, 135.2, 148.6, 189.5. MS-ESI (m/z): [M + H]+ = 244.9.

References

[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 18, p. 8276 - 8292
[2] Patent: WO2017/17004, 2017, A1. Location in patent: Page/Page column 17
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 10, p. 2192 - 2196
[4] Tetrahedron Letters, 2011, vol. 52, # 31, p. 4026 - 4029
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 10, p. 1424 - 1430

3-Nitrophenacylbromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Nitrophenacylbromide manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-Nitrophenacylbromide 2227-64-7
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Shanghai Xinchem Co., Ltd.

Product: 3-Nitrophenacylbromide 2227-64-7
Price: US $0.00-0.00/drums
Min. Order: 1drums
Purity: 99%min.
Supply Ability: 10tons
Release date: 2023-10-22

Career Henan Chemical Co

Product: 3-Nitrophenacylbromide 2227-64-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

2227-64-7, 3-NitrophenacylbromideRelated Search:

2-Bromo-5-nitropyridine PIPERACETAZINE (250 MG) Acetophenone 3'-Bromoacetophenone 2-Nitroacetophenone 3-Nitroacetophenone 2-Bromoacetophenone 4'-Bromoacetophenone 4-Nitroacetophenone Bromine 2-Bromo-2'-nitroacetophenone 4-Nitrobenzyl bromide 2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 2-Bromo-4'-nitroacetophenone 4'-BROMO-3'-NITROACETOPHENONE 2-BROMO-1-(5-ETHYL-2-METHOXY-3-NITROPHENYL)ETHANONE 2-BROMO-1-(5-CHLORO-2-METHOXY-4-METHYL-3-NITRO-PHENYL)ETHANONE 2-BROMO-1-(4-CHLORO-3-NITROPHENYL)ETHAN-1-ONE

2-Bromo-3'-nitroacetophenone,97%

2-Bromo-3'-nitroacetophenone, 2-Bromo-1-(3-nitrophenyl)ethan-1-one

2-BroMo-3&priMe

3-Nitro-ɑ-broMoacetophenone

2-Bromo-3'-nitroacetophenone 97%

2-BROMO-1-(3-NITRO-PHENYL)-ETHANONE

2-bromo-1-(3-nitrophenyl)ethan-1-one

3-nitrophenacyl bromide ,2-bromo-1-(3-nitrophenyl)ethanone

a-Bromo-3itroacetophenone

3'-Nitro-α-bromoacetophenone

A-BROMO-3-NITROACETOPHENONE

A-BROMO-M-NITROACETOPHENONE

AKOS BBS-00003963

3'-NITRO-2-BROMO ACETOPHENONE

3'-NITROPHENACYL BROMIDE

3-NITROPHENACYL BROMIDE

3-NITRO-ALPHA-BROMOACETOPHENONE

LABOTEST-BB LT00233190

M-NITROPHENACYL BROMIDE

3-Nitrophenacylbromide, 97+

alpha-Bromo-3'-nitroacetopheno

Acetophenone, 2-bromo-3'-nitro-

alpha-Bromo-m-nitroacetophenone

-Bromo-3-nltroacetopheone

Ethanone, 2-bromo-1-(3-nitrophenyl)-

omega-Bromo-m-nitroacetophenone

3-Nitrophenacylbromid

3''-NITROPHENACYL BROMIDE (2-BROMO-3''-NITROACETOPHENONE)

-Bromo-3-nitroacetophenone

à-bromo-3-nitroacetophenone

2-Bromo-3'-nitroacetophenone &gt

2-Bromo-3'-nitroacetophenone

Alpha-Bromo-3'-nitroacetophenone

2-Bromo-3′-nitroacetophenone, CAS 2227-64-7

2227-64-7

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