ChemicalBook > CAS DataBase List > 4-(Trifluoromethylthio)aniline

4-(Trifluoromethylthio)aniline

Uses

Product Name: 4-(Trifluoromethylthio)aniline
CAS No.: 372-16-7
Chemical Name: 4-(Trifluoromethylthio)aniline
Synonyms: BUTTPARK 44\10-22;IFLAB-BB F1902-0003;Pirtobrutinib Impurity 10;P-trifluoromethylthioaniline;4-(TRIFLUOROMETHYLTHIO)ANILINE;4-(TRIFLUOROMETHYLSULFANYL)ANILINE;4-(TRIFLUOROMETHYLTHIO)ANILINE 99%;4-(Trifluoromethylthio)aniline,95%;4-[(Trifluoromethyl)thio]benzenamine;4-AMINOPHENYL TRIFLUOROMETHYL SULFIDE
CBNumber: CB2332448
Molecular Formula: C7H6F3NS
Formula Weight: 193.19
MOL File: 372-16-7.mol

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4-(Trifluoromethylthio)aniline Property

Boiling point:: 102-103 °C/8 mmHg (lit.)
Density: 1.351 g/mL at 25 °C (lit.)
refractive index: n20/D 1.528(lit.)
Flash point:: 224 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Liquid
pka: 2.79±0.10(Predicted)
Specific Gravity: 1.351
color: Clear colorless to yellow
Water Solubility: insoluble
BRN: 2208859
InChI: InChI=1S/C7H6F3NS/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey: OHHHTUXVBNGOGI-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(SC(F)(F)F)C=C1
CAS DataBase Reference: 372-16-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzenamine, 4-[(trifluoromethyl)thio]-(372-16-7)

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Safety

Hazard Codes: Xn,T,Xi
Risk Statements: 20/21/22
Safety Statements: 36-36/37
RIDADR: UN2810
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 470074
Product name: 4-(Trifluoromethylthio)aniline
Purity: 97%
Packaging: 1g
Price: $59.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: 470074
Product name: 4-(Trifluoromethylthio)aniline
Purity: 97%
Packaging: 5g
Price: $264
Updated: 2023/06/20

TCI Chemical

Product number: T2775
Product name: 4-(Trifluoromethylthio)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: T2775
Product name: 4-(Trifluoromethylthio)aniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $244
Updated: 2025/07/31

TRC

Product number: T900570
Product name: 4-[(Trifluoromethyl)sulfanyl]anilineHydrochloride
Packaging: 5g
Price: $90
Updated: 2021/12/16

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4-(Trifluoromethylthio)aniline Chemical Properties,Usage,Production

Uses

p-Trifluoromethylthioaniline is a useful compound as a manufacturing intermediate for pesticides such as insecticides and acaricides.

Chemical Properties

clear colorless to yellow liquid

General Description

4-(Trifluoromethylthio)aniline is a 4-substituted aniline derivative.

Synthesis

403-66-7

372-16-7

General procedure for the synthesis of 4-((trifluoromethyl)thio)aniline from 4-trifluoromethylthio nitrobenzene: A palladium-carbon catalyst (10% Pd/C, 3.5 g) was added to a solution of 4-nitrophenyl trifluoromethyl sulfide (33.5 g, 0.15 mol) in ethanol (400 mL). The reaction mixture was placed in an autoclave and hydrogenated in a hydrogen atmosphere at 40 atm at room temperature for 8 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed well with ethanol. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. The residue was washed with water to give 28.4 g (98% yield) of 4-aminophenyl trifluoromethyl sulfide as a brown liquid. The product was characterized as follows: melting point: 110-112 °C/1.70 KPa (literature value: b.p. 113 °C/1.73 KPa); 1H NMR (300 MHz, CDCl3) δ 7.62 (d, J = 8.30 Hz, 2H), 7.42 (dd, J = 8.30 Hz, J = 1.90 Hz, 2H), 3.84 (s, 2H NH2); 19F NMR (220 MHz, CDCl3) δ 44.5 (s, 3F, SCF3); 13C NMR (75 MHz, CDCl3) δ 149.1, 138.2, 126.7, 115.3, 111.3.

References

[1] Journal of Fluorine Chemistry, 2007, vol. 128, # 6, p. 636 - 640
[2] Asian Journal of Chemistry, 2017, vol. 29, # 1, p. 91 - 93
[3] Zhurnal Obshchei Khimii, 1952, vol. 22, p. 2216,2219; engl. Ausg. S. 2273, 2276
[4] Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1967, vol. 23, p. 1351 - 1372

4-(Trifluoromethylthio)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(Trifluoromethylthio)aniline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-(Trifluoromethylthio)aniline 372-16-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(Trifluoromethylthio)aniline 372-16-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-26

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(Trifluoromethylthio)aniline 372-16-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-06-13

372-16-7, 4-(Trifluoromethylthio)anilineRelated Search:

o-Toluidine 4-(Trifluoromethoxy)aniline 2-Fluoroaniline 4-(Trifluoromethylthio)phenol 4-Aminobenzotrifluoride 3-Fluoroaniline p-Toluidine 4-Fluoroaniline Aniline p-Anisidine 3-Aminobenzotrifluoride 4-(TRIFLUOROMETHYLSULFONYL)ANILINE 3-CHLORO-4-(TRIFLUOROMETHYLTHIO)ANILINE 4-(Trifluoromethylthio)nitrobenzene 3-(Trifluoromethylthio)aniline, 97+%,3-(TRIFLUOROMETHYLTHIO)ANILINE 2-(Trifluoromethylthio)aniline, 97+%,2-(TRIFLUOROMETHYLTHIO)ANILINE N,N-DIMETHYL-4-(TRIFLUOROMETHYLTHIO)-ANILINE 4-(TRIFLUOROMETHYLTHIO)PHENYL ISOCYANATE

4-Trifluoromethylsulfanyl-phenylamine

4-Aminophenyl trifluoromethyl sulphide 96%

4-Aminophenyltrifluoromethylsulphide96%

4-(TRIFLUOROMETHYLTHIO)ANILINE 99%

4-Aminophenyl trifluoromethyl sulphi

4-[(Trifluoromethyl)thio]benzenamine

4-(Trifluoromethylthio)aniline,95%

4-Aminophenyl trifluoromethyl sulphide, 4-[(Trifluoromethyl)sulphanyl]aniline

4-(TRIFLUOROMETHYLTHIO)ANILINE

4-(TRIFLUOROMETHYLSULFANYL)ANILINE

4-AMINOPHENYL TRIFLUOROMETHYL SULFIDE

4-AMINOPHENYL TRIFLUOROMETHYL SULPHIDE

IFLAB-BB F1902-0003

BUTTPARK 44\10-22

Benzenamine, 4-[(trifluoromethyl)thio]-

P-trifluoromethylthioaniline

4-[(Trifluoromethyl)sulfanyl]aniline Hydrochloride

Pirtobrutinib Impurity 10

372-16-7

Organic Building Blocks

Sulfur Compounds

Sulfides/Disulfides

Building Blocks

Organic Building Blocks

Sulfides/Disulfides

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