4-(Trifluoromethylthio)aniline
Uses- Product Name
- 4-(Trifluoromethylthio)aniline
- CAS No.
- 372-16-7
- Chemical Name
- 4-(Trifluoromethylthio)aniline
- Synonyms
- BUTTPARK 44\10-22;IFLAB-BB F1902-0003;Pirtobrutinib Impurity 10;P-trifluoromethylthioaniline;4-(TRIFLUOROMETHYLTHIO)ANILINE;4-(TRIFLUOROMETHYLSULFANYL)ANILINE;4-(TRIFLUOROMETHYLTHIO)ANILINE 99%;4-(Trifluoromethylthio)aniline,95%;4-[(Trifluoromethyl)thio]benzenamine;4-AMINOPHENYL TRIFLUOROMETHYL SULFIDE
- CBNumber
- CB2332448
- Molecular Formula
- C7H6F3NS
- Formula Weight
- 193.19
- MOL File
- 372-16-7.mol
4-(Trifluoromethylthio)aniline Property
- Boiling point:
- 102-103 °C/8 mmHg (lit.)
- Density
- 1.351 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.528(lit.)
- Flash point:
- 224 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Liquid
- pka
- 2.79±0.10(Predicted)
- Specific Gravity
- 1.351
- color
- Clear colorless to yellow
- Water Solubility
- insoluble
- BRN
- 2208859
- InChI
- InChI=1S/C7H6F3NS/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
- InChIKey
- OHHHTUXVBNGOGI-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(SC(F)(F)F)C=C1
- CAS DataBase Reference
- 372-16-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzenamine, 4-[(trifluoromethyl)thio]-(372-16-7)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 470074
- Product name
- 4-(Trifluoromethylthio)aniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $59.3
- Updated
- 2023/06/20
- Product number
- 470074
- Product name
- 4-(Trifluoromethylthio)aniline
- Purity
- 97%
- Packaging
- 5g
- Price
- $264
- Updated
- 2023/06/20
- Product number
- T2775
- Product name
- 4-(Trifluoromethylthio)aniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- T2775
- Product name
- 4-(Trifluoromethylthio)aniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $244
- Updated
- 2025/07/31
- Product number
- T900570
- Product name
- 4-[(Trifluoromethyl)sulfanyl]anilineHydrochloride
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
4-(Trifluoromethylthio)aniline Chemical Properties,Usage,Production
Uses
p-Trifluoromethylthioaniline is a useful compound as a manufacturing intermediate for pesticides such as insecticides and acaricides.
Chemical Properties
clear colorless to yellow liquid
General Description
4-(Trifluoromethylthio)aniline is a 4-substituted aniline derivative.
Synthesis
403-66-7
372-16-7
General procedure for the synthesis of 4-((trifluoromethyl)thio)aniline from 4-trifluoromethylthio nitrobenzene: A palladium-carbon catalyst (10% Pd/C, 3.5 g) was added to a solution of 4-nitrophenyl trifluoromethyl sulfide (33.5 g, 0.15 mol) in ethanol (400 mL). The reaction mixture was placed in an autoclave and hydrogenated in a hydrogen atmosphere at 40 atm at room temperature for 8 hours. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filter cake was washed well with ethanol. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. The residue was washed with water to give 28.4 g (98% yield) of 4-aminophenyl trifluoromethyl sulfide as a brown liquid. The product was characterized as follows: melting point: 110-112 °C/1.70 KPa (literature value: b.p. 113 °C/1.73 KPa); 1H NMR (300 MHz, CDCl3) δ 7.62 (d, J = 8.30 Hz, 2H), 7.42 (dd, J = 8.30 Hz, J = 1.90 Hz, 2H), 3.84 (s, 2H NH2); 19F NMR (220 MHz, CDCl3) δ 44.5 (s, 3F, SCF3); 13C NMR (75 MHz, CDCl3) δ 149.1, 138.2, 126.7, 115.3, 111.3.
References
[1] Journal of Fluorine Chemistry, 2007, vol. 128, # 6, p. 636 - 640
[2] Asian Journal of Chemistry, 2017, vol. 29, # 1, p. 91 - 93
[3] Zhurnal Obshchei Khimii, 1952, vol. 22, p. 2216,2219; engl. Ausg. S. 2273, 2276
[4] Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 1967, vol. 23, p. 1351 - 1372
4-(Trifluoromethylthio)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Trifluoromethylthio)aniline manufacturers
- Product
- 4-(Trifluoromethylthio)aniline 372-16-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-04
- Product
- 4-(Trifluoromethylthio)aniline 372-16-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-26
- Product
- 4-(Trifluoromethylthio)aniline 372-16-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-06-13