ChemicalBook > CAS DataBase List > N-Hydroxyphthalimide

N-Hydroxyphthalimide

Product Name: N-Hydroxyphthalimide
CAS No.: 524-38-9
Chemical Name: N-Hydroxyphthalimide
Synonyms: nhpi;2-hydroxyisoindoline-1,3-dione;hydroxyphthalimide;2-hydroxyisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-hydroxy-;HOPHT;H-HYDROXY PHTHALIMIDE;2-Hydroxy-1H-isoindole-1,3(2H)-dione;2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;f802
CBNumber: CB2332640
Molecular Formula: C8H5NO3
Formula Weight: 163.13
MOL File: 524-38-9.mol

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N-Hydroxyphthalimide Property

Melting point:: 233 °C (dec.) (lit.)
Boiling point:: 290.19°C (rough estimate)
Density: 1.64 g/cm3
vapor pressure: 0Pa at 25℃
refractive index: 1.5510 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Powder
pka: 6.10±0.20(Predicted)
color: Yellow
Water Solubility: Slightly soluble in water.
Merck: 14,4838
BRN: 131208
InChIKey: CFMZSMGAMPBRBE-UHFFFAOYSA-N
LogP: 0.14
CAS DataBase Reference: 524-38-9(CAS DataBase Reference)
EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: TI5200000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29251995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H53704
Product name: N-Hydroxyphthalimide
Purity: 97%
Packaging: 5g
Price: $25.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: H53704
Product name: N-Hydroxyphthalimide
Purity: 97%
Packaging: 100g
Price: $50.5
Updated: 2025/07/31

TCI Chemical

Product number: H0395
Product name: N-Hydroxyphthalimide
Purity: >99.0%(T)
Packaging: 25g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: H0395
Product name: N-Hydroxyphthalimide
Purity: >99.0%(T)
Packaging: 100g
Price: $49
Updated: 2025/07/31

Sigma-Aldrich

Product number: H53704
Product name: N-Hydroxyphthalimide
Purity: 97%
Packaging: 500g
Price: $167
Updated: 2025/07/31

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N-Hydroxyphthalimide Chemical Properties,Usage,Production

Chemical Properties

N-Hydroxyphthalimide is yellow moist powder

Uses

Catalyst for oxidation reactions.

Uses

N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product.

Uses

Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts.

Application

N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0

reaction suitability

reaction type: Addition Reactions

Purification Methods

N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]

N-Hydroxyphthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL N-(BENZYLOXY)CARBAMATE 1-Adamantanol synthetic tanning agent No.742 5-Hydroxy-1,4-naphthalenedione 1,3-Adamantanediol O-(2,3,4,5,6-PENTAFLUOROBENZYL)HYDROXYLAMINE HYDROCHLORIDE synthetic tanning agent HV

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View Lastest Price from N-Hydroxyphthalimide manufacturers

RongNa Biotechnology Co.,Ltd

Product: N-Hydroxyphthalimide 524-38-9
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N-Hydroxyphthalimide 524-38-9
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kgs
Release date: 2021-08-26

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-Hydroxyphthalimide 524-38-9
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

524-38-9, N-HydroxyphthalimideRelated Search:

N-Hydroxysuccinimide O-Phthalimide Bismaleimide 4-Nitrophthalimide Phthalhydrazide N-Hydroxysulfosuccinimide sodium salt Succinimide N-Methylphthalimide 1,2-Cyclohexanedicarboximide 4-Aminophthalimide Potassium phthalimide HOAt N-Isopropylacrylamide CAPRYLOHYDROXAMIC ACID N-Hydroxyacetamidine D-Threo-Dihydroxyphenylserine MLMBILXCWROGFT-YVOIDUNUSA-N Droxidopa Impurity 4

TIMTEC-BB SBB009098

N-HYDROXY-PHTALIMIDE

N-HYDROXYPHTHALIMIDE

2-hydroxy-1h-isoindole-3(2h)-dione

N-Hydroxyphthalimide, remainder 10-15% moisture

N-Hydroxyphehtalimide

N-HYDROXYMETHYL-3-METHYLOXETANE

N-Hydroxyphthalimide(Nop)

N-Hydroxyphthalimide,98+%

N-Hydroxyphthalimide,99%

1H-Isoindole-1,3(2H)-dione, 2-hydroxy-

nhpi

N-Hydroxymethyl-3-methyloxetane（N-Hydroxyphthalimide

2-hydroxyisoindole-1,3-dione

N-(hydroxy)phthaltmde

N-HYDROXYPHTHALIMIDE pure

PHTHALOXIME

2-Hydroxy-2H-isoindole-1,3-dione

Phthalimidyl alcohol

NHPI NOP

N-Hydroxyphthalimide, remainder 10-15% moisture,99%

2-hydroxyisoindoline-1,3-dione

N-(hydroxy)phthaltmd

N-(HYDROCU)PHTHALIMDE

2-Hydroxy-1H-isoindole-1,3(2H)-dione

N-HydroxyphthaL

2-hydroxyphthalimide

Phthalimide,N-hydroxy-

<i>N</i>-Hydroxyphthalimide

N-Hydroxyphthalimide Vetec(TM) reagent grade, 97%

N-Hydroxyphthalimide≥ 99% (Assay)

f802

hydroxyphthalimide

n-hydroxy-phthalimid

AURORA KA-3774

HOPHT

H-HYDROXY PHTHALIMIDE

LABOTEST-BB LT00005723

2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione

N-HYDROXYPHTHALIMIDE FOR SYNTHESIS

2-Hydroxy-1H-isoindole-1,3(2H)-dione, 2-Hydroxyisoindolin-1,3-dione

N - hydroxy phthalates forMyl aMine

N-Hydroxyphthalimide&gt

N-Hydroxyphthalimide, 98%, for synthesis

Droxidopa Impurity 14

N-Hydroxyphthalimide USP/EP/BP

N-Hydrophthalimide

Drxidopa impurity 11

N-Hydroxyphthalimide, 97%

524-38-9

Carbon Radical Producing Catalysts (Environmentally-friendly Oxidation)

Peptide Synthesis

Condensation & Active Esterification

Coupling Reactions (Peptide Synthesis)

Coupling

Synthetic Reagents

Environmentally-friendly Oxidation

N-Substituted Maleimides, Succinimides & Phthalimides