N-Hydroxyphthalimide
- Product Name
- N-Hydroxyphthalimide
- CAS No.
- 524-38-9
- Chemical Name
- N-Hydroxyphthalimide
- Synonyms
- nhpi;2-hydroxyisoindoline-1,3-dione;hydroxyphthalimide;2-hydroxyisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-hydroxy-;HOPHT;H-HYDROXY PHTHALIMIDE;2-Hydroxy-1H-isoindole-1,3(2H)-dione;2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;f802
- CBNumber
- CB2332640
- Molecular Formula
- C8H5NO3
- Formula Weight
- 163.13
- MOL File
- 524-38-9.mol
N-Hydroxyphthalimide Property
- Melting point:
- 233 °C (dec.) (lit.)
- Boiling point:
- 290.19°C (rough estimate)
- Density
- 1.64 g/cm3
- vapor pressure
- 0Pa at 25℃
- refractive index
- 1.5510 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Powder
- pka
- 6.10±0.20(Predicted)
- color
- Yellow
- Water Solubility
- Slightly soluble in water.
- Merck
- 14,4838
- BRN
- 131208
- InChIKey
- CFMZSMGAMPBRBE-UHFFFAOYSA-N
- LogP
- 0.14
- CAS DataBase Reference
- 524-38-9(CAS DataBase Reference)
- EPA Substance Registry System
- 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- TI5200000
- TSCA
- Yes
- HazardClass
- IRRITANT
- HS Code
- 29251995
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H53704
- Product name
- N-Hydroxyphthalimide
- Purity
- 97%
- Packaging
- 5g
- Price
- $24.8
- Updated
- 2024/03/01
- Product number
- H53704
- Product name
- N-Hydroxyphthalimide
- Purity
- 97%
- Packaging
- 100g
- Price
- $49
- Updated
- 2024/03/01
- Product number
- H0395
- Product name
- N-Hydroxyphthalimide
- Purity
- >99.0%(T)
- Packaging
- 25g
- Price
- $17
- Updated
- 2024/03/01
- Product number
- H0395
- Product name
- N-Hydroxyphthalimide
- Purity
- >99.0%(T)
- Packaging
- 100g
- Price
- $46
- Updated
- 2024/03/01
- Product number
- A13862
- Product name
- N-Hydroxyphthalimide, 98+%
- Packaging
- 100g
- Price
- $43.7
- Updated
- 2024/03/01
N-Hydroxyphthalimide Chemical Properties,Usage,Production
Chemical Properties
N-Hydroxyphthalimide is yellow moist powder
Uses
Catalyst for oxidation reactions.
Uses
N-Hydroxyphthalimide，additives in to DCC method of peptide synthesis used to improve yield of optically pure product.
Uses
Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts.
Application
N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0
Purification Methods
N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]
N-Hydroxyphthalimide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Hydroxyphthalimide Suppliers
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- Country
- Switzerland
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View Lastest Price from N-Hydroxyphthalimide manufacturers
- Product
- N-Hydroxyphthalimide 524-38-9
- Price
- US $120.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-30
- Product
- N-Hydroxyphthalimide 524-38-9
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kgs
- Release date
- 2021-08-26
- Product
- N-Hydroxyphthalimide 524-38-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-22