m-(Trifluoromethyl)phenylacetic acid

Product Name: m-(Trifluoromethyl)phenylacetic acid
CAS No.: 351-35-9
Chemical Name: m-(Trifluoromethyl)phenylacetic acid
Synonyms: 2-(3-(TRIFLUOROMET;TIMTEC-BB SBB000433;RARECHEM AL BO 0127;m-(Trifluoromethyl)p;Inter-trifluoroMethyl acid;3-(TriflurorMethyl)benzylbroMide;3-TRIFLUOROMETHYPHENYLACETIC ACID;3-(Carboxymethyl)benzotrifluoride;(A,A,A-TRIFLUORO-M-TOLYL)ACETIC ACID;3-(trifluoromethyl)-benzeneaceticaci
CBNumber: CB2336956
Molecular Formula: C9H7F3O2
Formula Weight: 204.15
MOL File: 351-35-9.mol

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m-(Trifluoromethyl)phenylacetic acid Property

Melting point:: 76-79 °C(lit.)
Boiling point:: 238C/775Torr
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.14±0.10(Predicted)
color: White to Almost white
BRN: 2213223
InChI: InChI=1S/C9H7F3O2/c10-9(11,12)7-3-1-2-6(4-7)5-8(13)14/h1-4H,5H2,(H,13,14)
InChIKey: BLXXCCIBGGBDHI-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=CC=CC(C(F)(F)F)=C1
CAS DataBase Reference: 351-35-9(CAS DataBase Reference)
EPA Substance Registry System: Benzeneacetic acid, 3-(trifluoromethyl)- (351-35-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
TSCA: T
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 193356
Product name: 3-(Trifluoromethyl)phenylacetic acid
Purity: 97%
Packaging: 10g
Price: $78.4
Updated: 2025/07/31

TCI Chemical

Product number: T1662
Product name: 3-(Trifluoromethyl)phenylacetic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: T1662
Product name: 3-(Trifluoromethyl)phenylacetic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $152
Updated: 2025/07/31

Oakwood

Product number: 002139
Product name: 3-(Trifluoromethyl)phenylacetic Acid
Purity: 97%
Packaging: 100g
Price: $220
Updated: 2021/12/16

AK Scientific

Product number: O788
Product name: 3-(Trifluoromethyl)phenylacetic Acid
Packaging: 100g
Price: $251
Updated: 2021/12/16

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m-(Trifluoromethyl)phenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow crystalline powder

Uses

m-(Trifluoromethyl)phenylacetic acid is used as a reactant in a mechanistic study on ligand-accelerated C-H activation reactions.

Synthesis

2338-76-3

351-35-9

General procedure for the synthesis of [3-(trifluoromethyl)phenyl]acetic acid from [3-(trifluoromethyl)phenyl]acetonitrile: [3-(trifluoromethyl)phenyl]acetonitrile (5.4 g, 0.03 mol) was mixed with an aqueous solution of sodium hydroxide (6 g, 0.15 mol) and heated to reflux overnight. Upon completion of the reaction, it was cooled to room temperature and the pH of the reaction solution was adjusted with dilute hydrochloric acid to 2. Subsequently, the precipitate precipitated was collected by filtration, washed with water and dried to afford [3-(trifluoromethyl)phenyl]acetic acid as a white solid (5.2 g, 87% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 7.6 (m, 4H, aromatic hydrogen), 3.7 (s, 2H, CH2).

References

[1] Patent: WO2008/104524, 2008, A1. Location in patent: Page/Page column 49
[2] Journal of medicinal chemistry, 1968, vol. 11, # 6, p. 1258 - 1262
[3] Arzneimittel Forschung, 1965, vol. 15, p. 1251 - 1253
[4] Journal of the American Chemical Society, 1977, vol. 99, # 9, p. 3059 - 3067
[5] Journal of the American Chemical Society, 1982, vol. 104, # 7, p. 1937 - 1951

m-(Trifluoromethyl)phenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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m-(Trifluoromethyl)phenylacetic acid Suppliers

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View Lastest Price from m-(Trifluoromethyl)phenylacetic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: m-(Trifluoromethyl)phenylacetic acid 351-35-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-26

Shaanxi Dideu Medichem Co. Ltd

Product: m-(Trifluoromethyl)phenylacetic acid 351-35-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1KG
Release date: 2024-05-30

Career Henan Chemical Co

Product: m-(Trifluoromethyl)phenylacetic acid 351-35-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: 1ton
Release date: 2019-12-18

351-35-9, m-(Trifluoromethyl)phenylacetic acidRelated Search:

2-Methylbenzotrifluoride 2-(Trifluoromethyl)benzoic acid Glycine Folic acid 3-(Trifluoromethyl)benzaldehyde Ethyl 2-(Chlorosulfonyl)acetate Trifluoromethanesulfonic acid 2-Aminobenzotrifluoride 3-Trifluoromethylphenol 3-Trifluoromethylbenzylcyanide 3-(TRIFLUOROMETHYL)PHENETHYLAMINE 3-(Trifluoromethyl)cinnamic acid 3'-(Trifluoromethyl)acetophenone Phenylacetic acid 4-Fluoro-2-(trifluoromethyl)phenylacetic acid 98% 3-Fluoro-5-(trifluoroMethyl)phenylacetic acid 2-(Trifluoromethyl)phenylacetic acid, 97+%,2-(Trifluoromethyl)phenylacetic acid 98% (R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

3-(TRIFLUOROMETHYL)PHENYLACETIC ACID

3-(trifluoromethyl)-benzeneaceticaci

(A,A,A-TRIFLUORO-M-TOLYL)ACETIC ACID

(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)ACETIC ACID

RARECHEM AL BO 0127

TIMTEC-BB SBB000433

Inter-trifluoroMethyl acid

M-(TRIFLUOROMETHYL)PHENYLACETIC ACID

(α,α,α-Trifluoro-m-tolyl)acetic acid

2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID

(alpha,alpha,alpha-trifluoro-3-tolyl)acetic acid

(à,à,à-trifluoro-m-tolyl)acetic acid

3-(Trifluoromethyl)phenylacetic acid 98%

3-(Trifluoromethyl)phenylaceticacid98%

3-(trifluoromethyl)-benzeneacetic acid

3-TRIFLUOROMETHYPHENYLACETIC ACID

(ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL)ACETIC ACID 98%

3-(Trifluoromethyl)phenylacetic acid ,99%

(alpha,alpha,alpha-Trifluoro-m-tolyl)acetic acid,98%

2-(3-(TRIFLUOROMET

m-(Trifluoromethyl)p

3-(Carboxymethyl)benzotrifluoride

3-(TriflurorMethyl)benzylbroMide

Benzeneacetic acid, 3-(trifluoromethyl)-

2-[3-(trifluoromethyl)phenyl]aceticaci

351-35-9

C9H6F3O2

Building Blocks

Carboxylic Acids

Carbonyl Compounds

C9

CARBOXYLIC ACID

Organic Building Blocks

Phenylacetic acid

API intermediates

Aromatic Phenylacetic Acids and Derivatives