ChemicalBook > CAS DataBase List > ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE

ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE

Product Name: ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE
CAS No.: 206257-39-8
Chemical Name: ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE
Synonyms: DK659;EOS-60328;UKRORGSYN-BB BBV-080772;Ethyl4-chloro-6-bromoquinoline-3-carboxylate;ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE;ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE-4;Ethyl6-bromo-4-chloroquinoline-3-carboxylate,97%;6-Bromo-4-chloro-3-quinolinecarboxylic acid ethyl ester;6-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Quinolinecarboxylic acid, 6-bromo-4-chloro-, ethyl ester
CBNumber: CB2342719
Molecular Formula: C12H9BrClNO2
Formula Weight: 314.56
MOL File: 206257-39-8.mol

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ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Property

Melting point:: 100-102°
Boiling point:: 378.3±37.0 °C(Predicted)
Density: 1.578
refractive index: 1.632
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.98±0.27(Predicted)
Appearance: White to off-white Solid
Water Solubility: Immiscible in water.
InChI: InChI=1S/C12H9BrClNO2/c1-2-17-12(16)9-6-15-10-4-3-7(13)5-8(10)11(9)14/h3-6H,2H2,1H3
InChIKey: YGMLKBFPHVLHGT-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=CC=2)C(Cl)=C(C(OCC)=O)C=1

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
HazardClass: IRRITANT
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

AK Scientific

Product number: J57316
Product name: Ethyl6-bromo-4-chloroquinoline-3-carboxylate
Packaging: 1g
Price: $62
Updated: 2021/12/16

ChemScene

Product number: CS-M1122
Product name: ethyl6-bromo-4-chloroquinoline-3-carboxylate
Packaging: 1g
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 045032
Product name: Ethyl 6-bromo-4-chloro-3-quinoline carboxylate
Purity: >95%
Packaging: 500mg
Price: $95
Updated: 2021/12/16

BroadPharm

Product number: BP-20337
Product name: ethyl6-bromo-4-chloroquinoline-3-carboxylate
Purity: 98%
Packaging: 500mg
Price: $105
Updated: 2021/12/16

Matrix Scientific

Product number: 045032
Product name: Ethyl 6-bromo-4-chloro-3-quinoline carboxylate
Purity: >95%
Packaging: 1g
Price: $118
Updated: 2021/12/16

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ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 6-bromo-4-chloroquinoline-3-carboxylate is used as pharmaceutical intermediates

Synthesis

122794-99-4

206257-39-8

Ethyl 6-bromo-4-hydroxyquinoline-3-carboxylate (11 g, 37 mmol) was suspended in anhydrous dimethylformamide (148.6 mL) under nitrogen protection. Phosphoryl chloride (20.7 mL, 222 mmol, 6 equiv) was added slowly using a syringe. After addition, the reaction mixture was stirred vigorously for 3 hours at room temperature. Upon completion of the reaction, the mixture was slowly poured into ice water (1.5 L) and stirred continuously until the ice was completely melted. The precipitated solid product was collected by filtration, washed well with water until the washings were neutral, and subsequently dried under vacuum to constant weight. Ethyl 4-chloro-6-bromoquinoline-3-carboxylate (11.4 g, 94% yield) was finally obtained. Mass spectra (ESI) m/z (M + H) + 314.0, 316.0.

References

[1] Patent: US2012/184577, 2012, A1. Location in patent: Page/Page column 2; 3
[2] Patent: CN105859684, 2016, A. Location in patent: Paragraph 0148; 0149; 0150
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7585 - 7596
[4] RSC Advances, 2017, vol. 7, # 4, p. 2342 - 2350
[5] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 509 - 520

ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE manufacturers

Career Henan Chemical Co

Product: ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE 206257-39-8
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

206257-39-8, ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATERelated Search:

2-CYANO-5-ETHOXYCARBONYLPYRIDINE 6-BROMO-4-CHLORO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER 4,6-DICHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER ethyl2-methylquinoline-6-carboxylate 1H-Pyrazole-3-carboxylicacid,4-cyano-,ethylester(9CI) Ethyl 4-chloro-7-methoxyquinoline- 3-carboxylate ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 6-Bromo-2-naphthoic acid Ethyl 6-bromoindole-2-carboxylate 4-CHLORO-6-IODO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-Chloronicotinic acid ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE (4-Chloro-3-pyridinyl)methanol 6-BROMO-4-CHLOROQUINOLINE

6-BROMO-4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

UKRORGSYN-BB BBV-080772

6-Bromo-4-chloro-3-quinolinecarboxylic acid ethyl ester

ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE-4

ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE

EOS-60328

3-Quinolinecarboxylic acid, 6-bromo-4-chloro-, ethyl ester

Ethyl4-chloro-6-bromoquinoline-3-carboxylate

Ethyl6-bromo-4-chloroquinoline-3-carboxylate,97%

DK659

206257-39-8