ChemicalBook > CAS DataBase List > L-Glutamic acid 5-methyl ester

L-Glutamic acid 5-methyl ester

Product Name: L-Glutamic acid 5-methyl ester
CAS No.: 1499-55-4
Chemical Name: L-Glutamic acid 5-methyl ester
Synonyms: H-GLU(OME)-OH;(S)-2-aMino-5-Methoxy-5-oxopentanoic acid;Glu(Ome)-OH;L-GLUTAMIC ACID GAMMA-METHYL ESTER;Methyl L;L-Glu(Ome)-OH;H-L-GLU(ME)-OH;Duplicate of B24859;utamic acid 5-methyL;5-METHYL L-GLUTAMATE
CBNumber: CB2377021
Molecular Formula: C6H11NO4
Formula Weight: 161.16
MOL File: 1499-55-4.mol

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L-Glutamic acid 5-methyl ester Property

Melting point:: 182 °C (dec.) (lit.)
alpha: 13 º (c=1, H2O 24 ºC)
Boiling point:: 287.44°C (rough estimate)
Density: 1.3482 (rough estimate)
refractive index: 29 ° (C=2, 6mol/L HCl)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
Water Solubility: Soluble in water
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 2.18±0.10(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]20/D +29°, c = 2 in 6 M HCl
BRN: 1725252
InChI: InChI=1S/C6H11NO4/c1-11-5(8)3-2-4(7)6(9)10/h4H,2-3,7H2,1H3,(H,9,10)/t4-/m0/s1
InChIKey: ZGEYCCHDTIDZAE-BYPYZUCNSA-N
SMILES: C(O)(=O)[C@H](CCC(OC)=O)N
CAS DataBase Reference: 1499-55-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29224999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 858269
Product name: L-Glutamic acid 5-methyl ester
Purity: 99%
Packaging: 25g
Price: $132
Updated: 2025/07/31

TCI Chemical

Product number: M1690
Product name: 5-Methyl L-Glutamate
Purity: >98.0%(T)
Packaging: 5g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: M1690
Product name: 5-Methyl L-Glutamate
Purity: >98.0%(T)
Packaging: 25g
Price: $109
Updated: 2025/07/31

TRC

Product number: G597020
Product name: L-Glutamic acid 5-methyl ester
Packaging: 50g
Price: $210
Updated: 2021/12/16

AK Scientific

Product number: P967
Product name: L-Glutamic acid 5-methyl ester
Packaging: 500g
Price: $214
Updated: 2021/12/16

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L-Glutamic acid 5-methyl ester Chemical Properties,Usage,Production

Chemical Properties

white amorphous powder

Uses

L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).

Definition

ChEBI: L-glutamic acid 5-methyl ester is a glutamic acid 5-methyl ester having L-configuration. It is a L-glutamic acid derivative, a non-proteinogenic L-alpha-amino acid and a glutamic acid 5-methyl ester.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

56-86-0

1499-55-4

L-glutamic acid (22.1 g, 0.15 mol) was suspended in methanol (450 mL) at room temperature and under nitrogen protection. Subsequently, trimethylsilyl chloride (TMSCl, 35.9 g, 0.33 mol) was slowly added dropwise over a period of 5 min, at the end of which most of the solid was observed to be dissolved. Stirring of the reaction mixture was continued for 5 min and the progress of the reaction was monitored by thin layer chromatography (TLC, Spreader: 15% ammonia in methanol solution, Color Developer: ninhydrin) to confirm that only traces of the feedstock were present and that no bis-methyl esterified product was generated. After stirring again for 5 minutes, the reaction mixture was concentrated using a rotary evaporator and subsequently dried in a vacuum oven at 40 °C to give pure L-glutamic acid-5-methyl ester as a white solid. Yield: 30.0 g (100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CD3OD, ppm) δ 2.2 (2H, m), 2.6 (2H, m), 3.7 (3H, s), 4.1 (1H, t) and 13C NMR (75 MHz, CD3OD, ppm) δ 26.6, 30.4, 52.5, 53.2, 171.4, 174.3.

References

[1] Patent: US2016/16890, 2016, A1. Location in patent: Paragraph 0163
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 13, p. 3793 - 3797
[3] Tetrahedron Letters, 2010, vol. 51, # 9, p. 1333 - 1335
[4] Synthesis, 1987, # 7, p. 635 - 637
[5] Organic Process Research and Development, 2004, vol. 8, # 1, p. 72 - 85

L-Glutamic acid 5-methyl ester Preparation Products And Raw materials

Raw materials

Ammonium hydroxide L-Glutamic acid Diethyl ether Methanol Thionyl chloride

Preparation Products

Aceglutamide L-Glutamine

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View Lastest Price from L-Glutamic acid 5-methyl ester manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: L-Glutamic acid 5-methyl ester 1499-55-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-27

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Glu(OMe)-OH 1499-55-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-24

Henan Aochuang Chemical Co.,Ltd.

Product: L-Glutamic acid 5-methyl ester 1499-55-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

1499-55-4, L-Glutamic acid 5-methyl ester Related Search:

Methyl salicylate Polyglutamic acid L-Glutamic acid GLDH METSULFURON METHYL Methyl acrylate Glycine methyl ester hydrochloride L-Glutamic acid 5-tert-butyl ester Kresoxim-methyl Tribenuron methyl L-Glutamic acid dimethyl ester hydrochloride Diethyl L-glutamate hydrochloride (R)-N-Boc-glutamic acid-1,5-dimethyl ester Thiophanate-methyl L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE H-GLU(OTBU)-NH2 HCL L-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride L-Glutamic acid di-tert-butyl ester hydrochloride

L-GlutaMic acid 5-Methyl ester, 95+%

L-Glutamic acid 5-methyl ester 99%

L-Glutamic acid γ-methyl ester≥ 98.5% (HPLC)

Glu(Ome)-OH

(5)-methyl L-hydrogen glutamate

L-GUTAMIC ACID 5-METHYL ESTER 99%

L-Gutamic Acid 5-Methyl Ester

Mono-methyl-L-glutamate

L-Glutamicacid5-methylester,L-Glutamicacidγ-methylester

L-GLUTAMIC ACID-Y-METHYLESTER

Duplicate of B24859

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(S)-2-Aminoglutaric acid 5-methyl ester

3-(Methoxycarbonylmethyl)alanine

5-Methoxy-5-oxy-L-norvaline

L-Glutamic acid 5-methyl ester,99%

L-Glutamic Acid 5-Methyl Ester H-Glu(OMe)-OH

(S)-2-aMino-5-Methoxy-5-oxopentanoic acid

L-Glu(Ome)-OH

L-Glutamic acid 5-methylester Hydrochloride

utamic acid 5-methyL

L-Glutamicacidγ-methylester

L-GLUTAMIC ACID 5-METHYL ESTER

L-GLUTAMIC ACID GAMMA-METHYL ESTER

L-GLUTAMIC ACID, G-METHYL ESTER

H-L-GLU(ME)-OH

H-GLU(OME)-OH

GAMMA-L-GLU-METHYL ESTER

GAMMA-METHYL-L-GLUTAMATE

GLUTAMIC ACID DELTA-METHYL ESTER

GLUTAMIC ACID-GAMMA-METHYL ESTER

GLUTAMIC ACID(OME)-OH

5-METHYL L-GLUTAMATE

Methyl L

5-MethylL-Glutamate&gt

L-Glutamic acid 5-methyl ester USP/EP/BP

<sc>L</sc>-Glutamic acid 5-methyl ester

1499-55-4

CH3OCOCH2CH2CHNH2COOH

AMINE

Peptide Synthesis

Specialty Synthesis

Amino Acid Derivatives

Pyrazoles

Glutamic acid [Glu, E]

Amino Acids and Derivatives

Amino Acids Derivatives