ChemicalBook > CAS DataBase List > OREXIN B (HUMAN)

OREXIN B (HUMAN)

Product Name: OREXIN B (HUMAN)
CAS No.: 205640-91-1
Chemical Name: OREXIN B (HUMAN)
Synonyms: HYPOCRETIN-2;Human orexin B;OREXIN B (HUMAN);HYPOCRETIN-2, HUMAN;OREXIN B HUMAN ≥98%;PubChem ID: 90479794;OREXINS OREXIN B HUMAN;Orexin B, human - 1 mg;Orexin A/B 5mg (human);OREXIN B (HUMAN) USP/EP/BP
CBNumber: CB2384164
Molecular Formula: C123H212N44O35S
Formula Weight: 2899.34
MOL File: 205640-91-1.mol

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OREXIN B (HUMAN) Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: -20°C
form: lyophilized
Water Solubility: Soluble to 1 mg/ml in Water
Sequence: H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

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Safety

WGK Germany: 3
HS Code: 2937190000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SCP0204
Product name: Orexin B human
Packaging: 500μG
Price: $286
Updated: 2025/07/31

Sigma-Aldrich

Product number: SCP0204
Product name: Orexin B human
Packaging: 1MG
Price: $406
Updated: 2025/07/31

Cayman Chemical

Product number: 24765
Product name: Orexin B (human) (trifluoroacetate salt)
Purity: ≥95%
Packaging: 500μg
Price: $347
Updated: 2024/03/01

Tocris

Product number: 1456
Product name: Orexin B, human
Packaging: 500U
Price: $326
Updated: 2021/12/16

Usbiological

Product number: O7501-02
Product name: Orexin B, Human
Packaging: 1mg
Price: $313
Updated: 2021/12/16

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OREXIN B (HUMAN) Chemical Properties,Usage,Production

Description

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance. It is an agonist of orexin (OX) receptors with IC₅₀ values of 420 and 36 nM for human recombinant OX₁ and OX₂ receptors, respectively, expressed in CHO cells. It induces transient increases in intracellular calcium in CHO cells stably expressing OX₁ and OX₂ (EC₅₀s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons. Orexin B stimulates arachidonic acid release from CHO cells expressing human recombinant OX₁ (EC₅₀ = 4.17 nM). It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.

Uses

Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

Biochem/physiol Actions

Orexins/Hypocretins, Orexin A/ hypocretin-1 and Orexin B/ hypocretin-2, are excitatory neuropeptides that mediate there effects via two receptors, OX-1 and OX-2. Orexins are involved in food intake, obesity regulation, energy homeostasis and differentiation.

in vivo

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively^[2].

storage

-20°C (desiccate)

References

[1] Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. DOI:10.1093/bja/83.5.695
[2] Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. DOI:10.1016/s0092-8674(00)80949-6

OREXIN B (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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OREXIN B (HUMAN) Suppliers

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View Lastest Price from OREXIN B (HUMAN) manufacturers

Shenzhen Aoxi Technology Co., Ltd.

Product: Orexin A/B 5mg (human) 205640-91-1
Price: US $30.00-10.00/kit
Min. Order: 1kit
Purity: 99%
Supply Ability: 10000kits
Release date: 2025-03-17

Career Henan Chemical Co

Product: OREXIN B (HUMAN) 205640-91-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-13

205640-91-1, OREXIN B (HUMAN)Related Search:

2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE Ethyl isocyanoacetate Aluminum acetylacetonate TERT-BUTYL ISOCYANIDE Benzyl isocyanide Ferric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE SALCOMINE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tosylmethyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL COBALT(II) ACETYLACETONATE Orexin A (bovine, human, mouse, rat)

REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Orexin B (huMan) Hypocretin-2 (huMan)

OREXIN B HUMAN ≥98%

Orexin B (human), ≥98% (HPLC)

PubChem ID: 90479794

ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2

HYPOCRETIN-2

HYPOCRETIN-2, HUMAN

H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2

RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2

OREXINS OREXIN B HUMAN

OREXIN B (HUMAN)

Orexin B (human) (trifluoroacetate salt)

Human orexin B

L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-

OREXIN B (HUMAN) USP/EP/BP

Orexin B（Human）（Leu* U-13C6,15N）

Orexin B, human - 1 mg

Orexin A/B 5mg (human)

205640-91-1

C123H212N44O35S

C123H212N44O35S1

proteins

Peptide

Orexin receptor