ChemicalBook > CAS DataBase List > OREXIN B (HUMAN)

OREXIN B (HUMAN)

Product Name
OREXIN B (HUMAN)
CAS No.
205640-91-1
Chemical Name
OREXIN B (HUMAN)
Synonyms
HYPOCRETIN-2;Human orexin B;OREXIN B (HUMAN);HYPOCRETIN-2, HUMAN;OREXIN B HUMAN ≥98%;PubChem ID: 90479794;OREXINS OREXIN B HUMAN;Orexin B, human - 1 mg;Orexin A/B 5mg (human);OREXIN B (HUMAN) USP/EP/BP
CBNumber
CB2384164
Molecular Formula
C123H212N44O35S
Formula Weight
2899.34
MOL File
205640-91-1.mol
More
Less

OREXIN B (HUMAN) Property

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
-20°C
form 
lyophilized
Water Solubility 
Soluble to 1 mg/ml in Water
Sequence
H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
More
Less

Safety

WGK Germany 
3
HS Code 
2937190000
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SCP0204
Product name
Orexin B human
Packaging
500μG
Price
$286
Updated
2025/07/31
Sigma-Aldrich
Product number
SCP0204
Product name
Orexin B human
Packaging
1MG
Price
$406
Updated
2025/07/31
Cayman Chemical
Product number
24765
Product name
Orexin B (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$347
Updated
2024/03/01
Tocris
Product number
1456
Product name
Orexin B, human
Packaging
500U
Price
$326
Updated
2021/12/16
Usbiological
Product number
O7501-02
Product name
Orexin B, Human
Packaging
1mg
Price
$313
Updated
2021/12/16
More
Less

OREXIN B (HUMAN) Chemical Properties,Usage,Production

Description

Orexin B is a hypothalamic neuropeptide that regulates feeding behavior, wakefulness, and behavior under situations of high motivational relevance. It is an agonist of orexin (OX) receptors with IC50 values of 420 and 36 nM for human recombinant OX1 and OX2 receptors, respectively, expressed in CHO cells. It induces transient increases in intracellular calcium in CHO cells stably expressing OX1 and OX2 (EC50s = 2,500 and 60 nM, respectively) and in primary rat ventral tegmental area (VTA) dopaminergic neurons. Orexin B stimulates arachidonic acid release from CHO cells expressing human recombinant OX1 (EC50 = 4.17 nM). It also stimulates food intake in freely feeding mice and goldfish when administered at intracerebroventricular doses of 30 nmol and 10 ng/g, respectively.

Uses

Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

Biochem/physiol Actions

Orexins/Hypocretins, Orexin A/ hypocretin-1 and Orexin B/ hypocretin-2, are excitatory neuropeptides that mediate there effects via two receptors, OX-1 and OX-2. Orexins are involved in food intake, obesity regulation, energy homeostasis and differentiation.

in vivo

Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2].

storage

-20°C (desiccate)

References

[1] Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. DOI:10.1093/bja/83.5.695
[2] Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. DOI:10.1016/s0092-8674(00)80949-6

OREXIN B (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

OREXIN B (HUMAN) Suppliers

China 98 France 1 Germany 4 Japan 1 Switzerland 2 United Kingdom 5 United States 17 Global 128
NeoMPS SA
Tel
--
Fax
--
Email
neo@neomps.com
Country
France
ProdList
2083
Advantage
71
More
Less

View Lastest Price from OREXIN B (HUMAN) manufacturers

Shenzhen Aoxi Technology Co., Ltd.
Product
Orexin A/B 5mg (human) 205640-91-1
Price
US $30.00-10.00/kit
Min. Order
1kit
Purity
99%
Supply Ability
10000kits
Release date
2025-03-17
Career Henan Chemical Co
Product
OREXIN B (HUMAN) 205640-91-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-13

205640-91-1, OREXIN B (HUMAN)Related Search:

2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE Ethyl isocyanoacetate Aluminum acetylacetonate TERT-BUTYL ISOCYANIDE Benzyl isocyanide Ferric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE SALCOMINE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tosylmethyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL COBALT(II) ACETYLACETONATE Orexin A (bovine, human, mouse, rat)

  • REF DUPL: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
  • Orexin B (huMan) Hypocretin-2 (huMan)
  • OREXIN B HUMAN ≥98%
  • Orexin B (human), ≥98% (HPLC)
  • PubChem ID: 90479794
  • ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
  • HYPOCRETIN-2
  • HYPOCRETIN-2, HUMAN
  • H-ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
  • RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
  • OREXINS OREXIN B HUMAN
  • OREXIN B (HUMAN)
  • Orexin B (human) (trifluoroacetate salt)
  • Human orexin B
  • L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-
  • OREXIN B (HUMAN) USP/EP/BP
  • Orexin B（Human）（Leu* U-13C6,15N）
  • Orexin B, human - 1 mg
  • Orexin A/B 5mg (human)
  • 205640-91-1
  • C123H212N44O35S
  • C123H212N44O35S1
  • proteins
  • Peptide
  • Orexin receptor