ChemicalBook > CAS DataBase List > Nitrendipine
Nitrendipine
- Product Name
- Nitrendipine
- CAS No.
- 39562-70-4
- Chemical Name
- Nitrendipine
- Synonyms
- Nitrendipin;3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Deiten;nidrel;Nitrepin;baye5009;baypress;bayotensin;Bylotensin;NITRENDIPINE
- CBNumber
- CB2395104
- Molecular Formula
- C18H20N2O6
- Formula Weight
- 360.36
- MOL File
- 39562-70-4.mol
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Nitrendipine Property
- Melting point:
- 1580C
- Boiling point:
- 492.4°C (rough estimate)
- Density
- 1.3595 (rough estimate)
- refractive index
- 1.5700 (estimate)
- storage temp.
- 2-8°C
- solubility
- methanol: 15 mg/mL
- form
- powder
- pka
- 2.79±0.70(Predicted)
- color
- yellow to green
- Water Solubility
- Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
- Stability:
- Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
- CAS DataBase Reference
- 39562-70-4(CAS DataBase Reference)
- NIST Chemistry Reference
- Nitrendipine(39562-70-4)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- N144
- Product name
- Nitrendipine
- Purity
- >95%, powder
- Packaging
- 25mg
- Price
- $95.3
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- N144
- Product name
- Nitrendipine
- Purity
- >95%, powder
- Packaging
- 100mg
- Price
- $314
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J60841
- Product name
- Nitrendipine
- Packaging
- 100mg
- Price
- $160.65
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J60841
- Product name
- Nitrendipine
- Packaging
- 1g
- Price
- $570.65
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17549
- Product name
- Nitrendipine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
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Nitrendipine Chemical Properties,Usage,Production
Description
Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.
Chemical Properties
Crystalline Solid
Originator
Bayer (W. Germany)
Uses
Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.
Uses
Antihypertensive;Calcium channel blocker
Uses
Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.
Definition
ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.
brand name
Baypress (Bayer);BAYOTENSIN.
General Description
Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.
Biological Activity
L-type calcium channel blocker.
Biochem/physiol Actions
Ca2+ channel blocker; anti-hypertensive.
storage
Store at RT
References
1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions); Arzneimittelforschung 31 407 2) Stoepel et al., (1981), Pharmacological studies of the antihypertensive effect of nitrendipine; Arzneimittelforschung 31 2056
Nitrendipine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nitrendipine manufacturers
Sinoway Industrial co., ltd.
- Product
- Nitrendipine 39562-70-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-05-06
Hebei Duling International Trade Co. LTD
- Product
- Nitrendipine 39562-70-4
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100tons
- Release date
- 2023-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
- Product
- Nitrendipine 39562-70-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98.5~101.5%,BP2010
- Supply Ability
- 10kg/month
- Release date
- 2021-06-10
39562-70-4, NitrendipineRelated Search:
Nimodipine
1-(2,6-Dimethylphenoxy)-2-propanamine
Nitrendipine Propyl Ester
M-NIFEDIPINE
5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid
Nifedipine Impurity F
NSC 136464
Dehydronitrendipine
Nisoldipine
Iganidipine
Pranidipine
Benidipine
Palonidipine
S(+)-NIGULDIPINE HYDROCHLORIDE
Nilvadipine
3,5-Pyridinedicarboxylic acid
4-(3-Nitrophenyl)pyridine
EPN