Nitrendipine

Product Name: Nitrendipine
CAS No.: 39562-70-4
Chemical Name: Nitrendipine
Synonyms: Nitrendipin;3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Deiten;nidrel;Nitrepin;baye5009;baypress;bayotensin;Bylotensin;NITRENDIPINE
CBNumber: CB2395104
Molecular Formula: C18H20N2O6
Formula Weight: 360.36
MOL File: 39562-70-4.mol

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Nitrendipine Property

Melting point:: 1580C
Boiling point:: 492.4°C (rough estimate)
Density: 1.3595 (rough estimate)
refractive index: 1.5700 (estimate)
storage temp.: 2-8°C
solubility: methanol: 15 mg/mL
form: powder
pka: 2.79±0.70(Predicted)
color: yellow to green
Water Solubility: Soluble in DMSO (17.5 mg/ml), methanol (15 mg/ml), ethyl acetate, and ethanol (25 mM). Insoluble in water.
Stability:: Stable for 1 year from date of purchase as supplied. Protect from light. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 week.
CAS DataBase Reference: 39562-70-4(CAS DataBase Reference)
NIST Chemistry Reference: Nitrendipine(39562-70-4)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 1
RTECS: US5653000
Toxicity: LD50 in mice, rats (mg/kg): 39, 12.6 i.v.; 2540, >10000 orally (Hoffmann)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N144
Product name: Nitrendipine
Purity: >95%, powder
Packaging: 25mg
Price: $95.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: N144
Product name: Nitrendipine
Purity: >95%, powder
Packaging: 100mg
Price: $314
Updated: 2024/03/01

Alfa Aesar

Product number: J60841
Product name: Nitrendipine
Packaging: 100mg
Price: $160.65
Updated: 2024/03/01

Alfa Aesar

Product number: J60841
Product name: Nitrendipine
Packaging: 1g
Price: $570.65
Updated: 2024/03/01

Cayman Chemical

Product number: 17549
Product name: Nitrendipine
Purity: ≥95%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

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Nitrendipine Chemical Properties,Usage,Production

Description

Nitrendipine is a vasodilating, dihydropyridine calcium antagonist. Its prolonged therapeutic effect in comparison to nifedipine makes it useful in the once to twice daily treatment of hypertension.

Chemical Properties

Crystalline Solid

Originator

Bayer (W. Germany)

Uses

Nitrendipine modulates NMDA receptor channel function in mammalian neurons. Nitrendipine has been shown to inhibit neutrophil adhesion to vascular endothelium. It is used in the treatment of primary hypertension to decrease blood pressure. Nitrendipine is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina.

Uses

Antihypertensive;Calcium channel blocker

Uses

Nitrendipine is a dihydropyridine calcium channel blocker. Nitrendipine is used in the treatment of primary (essential) hypertension to decrease blood pressure. Antihypertensive.

Definition

ChEBI: A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in t e treatment of hypertension.

brand name

Baypress (Bayer);BAYOTENSIN.

General Description

Nitrendipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ethylester (Baypress), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissue andserves as an effective vasodilator. The drug is used in thetreatment of mild-to-moderate essential hypertension.

Biological Activity

L-type calcium channel blocker.

Biochem/physiol Actions

Ca2+ channel blocker; anti-hypertensive.

storage

Store at RT

References

1) Meyer et al., (1981), (Synthesis and comparative pharmacological studies of 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylates with non-identical ester functions); Arzneimittelforschung 31 407 2) Stoepel et al., (1981), Pharmacological studies of the antihypertensive effect of nitrendipine; Arzneimittelforschung 31 2056

Nitrendipine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate filter paper Methyl 3-aminocrotonate Methyl acetoacetate 3-Nitrobenzaldehyde

Preparation Products

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Nitrendipine Suppliers

Americas 1 Canada 2 China 350 Europe 3 France 1 Germany 4 Hungary 1 India 7 Japan 3 South Korea 1 Spain 2 Switzerland 2 United Kingdom 11 United States 46 Global 434

EDQM

Tel: --
Fax: --
Email: orders@edqm.eu
Country: France
ProdList: 1913
Advantage: 81

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View Lastest Price from Nitrendipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Nitrendipine 39562-70-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98.5~101.5%,BP2010
Supply Ability: 10kg/month
Release date: 2021-06-10

Sinoway Industrial co., ltd.

Product: Nitrendipine 39562-70-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-05-06

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Nitrendipine 39562-70-4
Price: US $0.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 500kg
Release date: 2020-11-10

39562-70-4, NitrendipineRelated Search:

Nimodipine 1-(2,6-Dimethylphenoxy)-2-propanamine Nitrendipine Propyl Ester M-NIFEDIPINE 5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid Nifedipine Impurity F NSC 136464 Dehydronitrendipine Nisoldipine Iganidipine Pranidipine Benidipine Palonidipine S(+)-NIGULDIPINE HYDROCHLORIDE Nilvadipine 3,5-Pyridinedicarboxylic acid 4-(3-Nitrophenyl)pyridine EPN

NITRENDIPINE

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidethy

baye5009

bayotensin

baypress

ethylmethyl1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxy

2，6-Dimethyl-4-(3-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl ethyl ester

Bylotensin

Deiten

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, ethyl methyl ester (9CI)

Nitrepin

Nitrendipin

Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-ethyl 3-methyl ester

4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl 5-methyl ester

3-ethyl 5-Methyl (4R)-2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Lercanidipine Ethyl Methyl Ester IMpurity (IMpurity 5)

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester

Nitrendipine for peak identification

(RS)-Methylethyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate

Nitrendipine, ≥95.0%

Group horizon

3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

lmethylester

nidrel

ylmethylester

ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(meta-nitrophenyl)-3,5-pyridinedicarboxylate

1,4-DIHYDRO-2,6-DIMETHYL-4-(3'-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER

1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER

NITRENDIPINE >95% CA2+ CHANNEL BLOCKER,

NITRENDIPINE EPN(CRM STANDARD)

(NITROPHENYLPYRIDINE ANALOGUE) EPN(CRM STANDARD)

NITRENDIPINE IMPURITY AETHYL METHYL-2,6-DIMETHYL-4-(3-NITROPHENYL) PYRIDINE-3,5-DICARBOXYLATE

NITRENDIPINE MM(CRM STANDARD)

Nitrendipine for system suitability CRS

Nitrendipine CRS

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-ethyl 5-methyl ester

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Ethyl Methyl Ester

Ethyl Methyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate

Nitrendipine USP/EP/BP

Nitrendipiner

Nitrendipine, Pharma

Lercanidipine methyl ethyl ester imp

Nitrendipine (BAY-E-5009)

Nitrendipine Impurity1218

Lercanidipine Ethyl Methyl Ester Impurity

Nitrendipine D5Q: What is Nitrendipine D5 Q: What is the CAS Number of Nitrendipine D5 Q: What is the storage condition of Nitrendipine D5

NitrendipineQ: What is Nitrendipine Q: What is the CAS Number of Nitrendipine Q: What is the storage condition of Nitrendipine Q: What are the applications of Nitrendipine

Group of horizon

Nitrendipine in methanol

39562-70-4

C18H20N2O6

36036

Calcium Channel Modulators

Cell Biology

Cell Signaling and Neuroscience

BioChemical

Ion Channels