ChemicalBook > CAS DataBase List > D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

Product Name: D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
CAS No.: 69630-50-8
Chemical Name: D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
Synonyms: (R)-DimethyL;H-D-Asp(OMe)-OH;D-Asp(OMe)-OMe·HCl;H-D-ASP(ME)-OME HCL;D-ASPARTIC ACID DIME;H-D-ASP(OME)-OME HCL;2-aminosuccinate hydrochL;D-ASPARTIC ACID(OME)-OME HCL;H-D-Asp(Me)-OMe hydrochloride;dimethyl (2R)-2-aminobutanedioate
CBNumber: CB2397092
Molecular Formula: C6H12ClNO4
Formula Weight: 197.62
MOL File: 69630-50-8.mol

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D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE Property

Melting point:: 114-119℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: Off-White
optical activity: Consistent with structure
InChI: InChI=1/C6H11NO4.ClH/c1-10-5(8)3-4(7)6(9)11-2;/h4H,3,7H2,1-2H3;1H/t4-;/s3
InChIKey: PNLXWGDXZOYUKB-NDILARRWNA-N
SMILES: [C@H](N)(C(=O)OC)CC(=O)OC.Cl |&1:0,r|
CAS DataBase Reference: 69630-50-8(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H332Harmful if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A788975
Product name: D-AsparticAcidDimethylEsterHydrochloride
Packaging: 1g
Price: $70
Updated: 2021/12/16

TRC

Product number: A788975
Product name: D-AsparticAcidDimethylEsterHydrochloride
Packaging: 5g
Price: $180
Updated: 2021/12/16

Usbiological

Product number: 260240
Product name: D-Aspartic acid dimethyl ester hydrochloride
Packaging: 1g
Price: $350
Updated: 2021/12/16

TRC

Product number: A788975
Product name: D-AsparticAcidDimethylEsterHydrochloride
Packaging: 25g
Price: $450
Updated: 2021/12/16

Matrix Scientific

Product number: 093641
Product name: H-D-Asp(OMe)-OH HCl
Purity: 95+%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.

Synthesis

67-56-1

1783-96-6

14358-33-9

106.8 g (0.8 mol) of D-aspartic acid and 700 ml of methanol were added to the reaction vessel and 84.4 ml (1.2 mol) of thionyl chloride was added slowly dropwise under stirring, controlling the reaction temperature to 0°C. After the dropwise addition, the reaction system was warmed up to room temperature (about 29°C) and the reaction was continued with stirring for 30 hours. Upon completion of the reaction, excess methanol and thionyl chloride were removed from the reaction solution by distillation. The remaining oily material was dissolved in 3.5 times the volume of ether for crystallization to obtain white crystals. After filtration, the crystals were washed with ether three times and dried to finally obtain 107.8 g of white solid DL-aspartic acid dimethyl ester hydrochloride.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10460 - 10474
[2] Journal of Organic Chemistry, 2012, vol. 77, # 5, p. 2299 - 2309
[3] Journal of Medicinal Chemistry, 2013, vol. 56, # 7, p. 2936 - 2947
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 24, p. 7215 - 7226
[5] Patent: WO2010/31184, 2010, A1. Location in patent: Page/Page column 22

D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: D-Asp(ome)-ome.HCl 69630-50-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-04

Career Henan Chemical Co

Product: D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE 69630-50-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-12

69630-50-8, D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDERelated Search:

H-DL-ASP(OME)-OH HCL L-Homoserine hydrochloride Methyl 3-aminopropionate hydrochloride D-ASPARTIC ACID-BETA-METHYL ESTER D-Aspartic acid D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE D-Homoserine D-Alanine Methyl Ester Hydrochloride L-beta-Homoalanine hydrochloride L-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE,L-ASPARTIC ACID, DIMETHYL ESTER, HYDROCHLORIDE SALT BETA-HOMOALANINE HYDROCHLORIDE DL-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE H-D-Asp(OtBu)-OtBu · HCl H-D-ASP-OME H-D-ASP(OTBU)-ALLYL ESTER HCL L-BETA-HOMOSERINE METHYL D-HOMOALANINATE HCL H-D-ASP(TBU)-OME HCL

H-D-ASP(OME)-OME HCL

H-D-ASP(ME)-OME HCL

D-ASPARTIC ACID-1,4-DIMETHYL ESTER HYDROCHLORIDE

1,4-dimethyl (2R)-2-aminobutanedioate hydrochloride

D-ASPARTIC ACID DIMETHYL ESTER HCL

D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

D-ASPARTIC ACID ALPHA,BETA-DIMETHYL ESTER HYDROCHLORIDE

D-ASPARTIC ACID(OME)-OME HCL

DIMETHYL D-ASPARTATE HYDROCHLORIDE

H-D-Asp(OMe)-OH

D-ASPARTIC ACID DIME

D-Asp(OMe)-OMe·HCl

D-Asparticacid,1,4-diMethylesterHCL

(R)-DiMethyl 2-aMinosuccinate hydrochloride

D-Aspartic acid,1,4-diMethyl ester, hydrochloride (1:1)

D-Aspartic acid dimethyl ester hydrochloride≥ 99% (HPLC)

H-D-Asp(Me)-OMe hydrochloride

(R)-DimethyL

2-aminosuccinate hydrochL

dimethyl (2R)-2-aminobutanedioate,hydrochloride

imethyl(2R)-2-aminobutanedioate,hydrochloride

D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE USP/EP/BP

dimethyl (2R)-2-aminobutanedioate

D-Aspartic acid dimethyl ester hydrochlo

69630-50-8

C6H11NO4ClH

Amino Acids Derivatives

Amino ester

Amino hydrochloride