Hydrocortisone sodium phosphate
- Product Name
- Hydrocortisone sodium phosphate
- CAS No.
- 6000-74-4
- Chemical Name
- Hydrocortisone sodium phosphate
- Synonyms
- Coriphate;Efcortesol;Physiocortison;Hydrocortone phosphate;CORTISOL SODIUM PHOSPHATE;Sodium cortisol 21-phosphate;Hydrocortisone 21-disodium salt;Hydrocortisone phosphate sodium;Hydrocortisone Sodium Phosphate;Hydrocortisone disodium phosphate
- CBNumber
- CB2397209
- Molecular Formula
- C21H29O8P.2Na
- Formula Weight
- 486.41
- MOL File
- 6000-74-4.mol
Hydrocortisone sodium phosphate Property
- alpha
- D25 +120° (H2O)
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 6000-74-4(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H312Harmful in contact with skin
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P314Get medical advice/attention if you feel unwell.
P322Specific measures (see …on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H714690
- Product name
- HydrocortisoneSodiumPhosphate
- Packaging
- 10g
- Price
- $1355
- Updated
- 2021/12/16
- Product number
- C870
- Product name
- Hydrocortisonesodiumphosphate
- Packaging
- 25mg
- Price
- $49
- Updated
- 2021/12/16
Hydrocortisone sodium phosphate Chemical Properties,Usage,Production
Originator
Corphos,Tilden Yates,US,1959
Uses
Hydrocortisone Sodium Phosphate is the sodium phosphate salt of the corticosteroid Hydrocortisone (H714615).
Definition
ChEBI: An organic sodium salt that is the disodium salt of cortisol phosphate.
Manufacturing Process
21-iodo-11β:17α-dihydroxypregn-4-ene-3,20-dione (5.0 g) in pure acetonitrile
(125 ml) was mixed with a solution of 90% phosphoric acid (2.5 ml) and
triethylamine (7.5 ml) in acetonitrile (125 ml) and boiled under reflux for 4
hours. The solvent was removed in vacuo and the residue, dissolved in
ethanol (20 ml) and water (80 ml), was passed down a column of Zeo-Karb
225 (H+form) (60 g) made up in 20% alcohol. Elution was continued with
20% alcohol (50 ml), 50% alcohol (50 ml) and alcohol (150 ml). The eluate
was at first cloudy, but by the end of the elution it was clear and nonacid.
The eluate was titrated to pH 7 with 0.972N NaOH (63 ml). Removal of
solvent left a gum, which was boiled with methanol (400 ml) for 20 minutes.
The solid insoluble inorganic phosphate was filtered off and washed with
methanol (200 ml). The slightly cloudy filtrate was filtered again, and
evaporated to dryness in vacuo. The residual gum dissolved readily in water
(40 ml) and on addition of acetone (600 ml) to the solution a mixture of
sodium salts of hydrocortisone 21-phosphate separated as a white solid. This
was collected after 2 days, washed with acetone and dried at 100°C/0.l mm/2
hr to constant weight. Yield 4.45 g.
brand name
Hydrocortone (Merck).
Therapeutic Function
Glucocorticoid
Hydrocortisone sodium phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hydrocortisone sodium phosphate manufacturers
- Product
- Hydrocortisone Sodium Phosphate 6000-74-4
- Price
- US $8.00/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23
- Product
- Hydrocortisone sodium phosphate 6000-74-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Hydrocortisone sodium phosphate 6000-74-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg ,5kg, 50kg
- Release date
- 2020-01-14