ChemicalBook > CAS DataBase List > 2-Amino-5-bromo-3-methylpyridine

2-Amino-5-bromo-3-methylpyridine

Product Name
2-Amino-5-bromo-3-methylpyridine
CAS No.
3430-21-5
Chemical Name
2-Amino-5-bromo-3-methylpyridine
Synonyms
5-BROMO-3-METHYLPYRIDIN-2-AMINE;5-BROMO-3-METHYL-PYRIDIN-2-YLAMINE;2-Amina-5-bromo;TIMTEC-BB SBB003694;2-Amino-5-bromo-3-methyl;2-AMINO-5-BROMO-3-PICOLINE;2-Amina-5-bromo-3-picoline;2-Amino-5-bromo-3-picoline,98%;5-Bromo-3-methyl-2-pyridinamine;2-AMINO-3-METHYL-5-BROMOPYRIDINE
CBNumber
CB2409508
Molecular Formula
C6H7BrN2
Formula Weight
187.04
MOL File
3430-21-5.mol
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2-Amino-5-bromo-3-methylpyridine Property

Melting point:
88-95 °C(lit.)
Boiling point:
250.0±35.0 °C(Predicted)
Density 
1.5672 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform, Methanol
form 
Solid
pka
4.96±0.49(Predicted)
color 
Yellow
Sensitive 
Hygroscopic
BRN 
386426
InChI
InChI=1S/C6H7BrN2/c1-4-2-5(7)3-9-6(4)8/h2-3H,1H3,(H2,8,9)
InChIKey
KBLGGRWUEVCNPY-UHFFFAOYSA-N
SMILES
C1(N)=NC=C(Br)C=C1C
CAS DataBase Reference
3430-21-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
525537
Product name
2-Amino-5-bromo-3-methylpyridine
Purity
97%
Packaging
5g
Price
$115
Updated
2025/07/31
Sigma-Aldrich
Product number
525537
Product name
2-Amino-5-bromo-3-methylpyridine
Purity
97%
Packaging
1g
Price
$49
Updated
2023/06/20
TCI Chemical
Product number
A2154
Product name
2-Amino-5-bromo-3-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
A2154
Product name
2-Amino-5-bromo-3-methylpyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$74
Updated
2025/07/31
TRC
Product number
A601829
Product name
2-Amino-5-bromo-3-methylpyridine
Packaging
10g
Price
$165
Updated
2021/12/16
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2-Amino-5-bromo-3-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

2-Amino-5-bromo-3-methylpyridine may be used to synthesize:

  • 5-bromo-2-chloro-3-methylpyridine
  • 2-azidopyridine 1-oxide
  • 2-amino-5-bromo-3-methylpyridine 1-oxide
  • 2,5-dibromo-3-methyl pyridine
  • ethyl-3,6-dibromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate

General Description

2-Amino-5-bromo-3-methylpyridine can be prepared from 2-amino-3-methylpyridine, via bromination.

Synthesis

1603-40-3

3430-21-5

General procedure for the synthesis of 2-amino-3-methyl-5-bromopyridine from 2-amino-3-methylpyridine: Bromine (15.4 mL, 0.30 mol) was slowly added dropwise to an anhydrous dichloromethane (1000 mL) solution of 2-amino-3-methylpyridine (32.44 g, 0.30 mol) under stirring at 0-2 °C for 1 hour. The cooling bath was then removed and the yellow suspension was allowed to continue stirring at room temperature for 3 hours and 40 minutes. Upon completion of the reaction, the mixture was alkalized to pH 9 with 2N sodium hydroxide solution (145 mL) and subsequently treated with a mixture of saturated aqueous sodium bicarbonate (100 mL) and saturated aqueous sodium thiosulfate (10 mL). The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated to give the brown solid product 2-amino-3-methyl-5-bromopyridine (56.83 g, 102% yield), which could be used in the next reaction without further purification.

References

[1] Patent: WO2004/13139, 2004, A2. Location in patent: Page 25-26
[2] Tetrahedron Letters, 2009, vol. 50, # 9, p. 1007 - 1009
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 11, p. 1129 - 1131
[4] Patent: CN105348177, 2016, A. Location in patent: Paragraph 0012; 0016
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697

2-Amino-5-bromo-3-methylpyridine Preparation Products And Raw materials

Raw materials

Hydrogen peroxide Sodium sulfite 2-Amino-3-picoline Hydrogen bromide Ethyl acetate Bromine Acetic acid

Preparation Products

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2-Amino-5-bromo-3-methylpyridine Suppliers

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View Lastest Price from 2-Amino-5-bromo-3-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Amino-5-bromo-3-methylpyridine 3430-21-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-30
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Amino-5-bromo-3-methylpyridine 3430-21-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Henan Aochuang Chemical Co.,Ltd.
Product
2-Amino-5-bromo-3-methylpyridine 3430-21-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-12

3430-21-5, 2-Amino-5-bromo-3-methylpyridineRelated Search:

2-Amino-5-bromo-3-(hydroxymethyl)pyridine 6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one Methyl 2-amino-5-bromonicotinate 5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE 2-Amino-5-bromonicotinic acid 5-BROMO-1H-PYRROLO[2 , 3-B]PYRIDIN-2(3H)-ONE (2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE 2-AMINO-5-BROMO-3,4-DIMETHYLPYRIDINE 2-Amino-5-bromo-3-methylpyridine 2-Acetylamino-5-bromo-3-methylpyridine 5-AMINO-2-BROMO-3-METHYLPYRIDINE,5-AMINO-2-BROMO-3-PICOLINE (5-AMINO-2-BROMO-3-METHYLPYRIDINE) 2-Amino-3-bromo-5-methylpyridine 4-Bromo-2-methyl-3-pyridinamine 4-AMINO-5-BROMO-3-METHYLPYRIDINE 3-Amino-2-bromo-4-methylpyridine 5-Amino-2-bromo-4-methylpyridine 2-AMINO-3-BROMO-4-METHYLPYRIDINE 3-Amino-5-bromo-2-methylpyridine

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  • 2-AMINO-5-BROMO-3-PICOLINE (2-AMINO-5-BROMO-3-METHYLPYRIDINE)
  • JR-8255, 2-Amino-5-bromo-3-methylpyridine, 97%
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  • 2-Amino-5-bromo-3-methylpyridine ,98%
  • 2-PyridinaMine, 5-broMo-3-Methyl-
  • TIMTEC-BB SBB003694
  • 5-BROMO-3-METHYLPYRIDIN-2-AMINE
  • 5-BROMO-3-METHYL-PYRIDIN-2-YLAMINE
  • 6-aMino-3-broMo-5-Methylpyridine
  • 2-Amino-5-bromo-3-picoline, 5-Bromo-3-methylpyridin-2-amine
  • 2-AMino-5-broMo-3-Methylpyridine SynonyMs 5-BroMo-3-Methylpyridin-2-aMine
  • 2-Amino-5-bromo-3-methylpyridine,97%
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  • 2-Amina-5-bromo
  • 2-Amino-5-bromo-3-methylpyridine &gt
  • 2-Amino-5-bromo-3-methylpyridine ISO 9001：2015 REACH
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  • "2-Amino-3-methyl-5-bromopyridine 13C4, 15N"
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  • 3430-21-5
  • 30-21-5
  • 430-21-5
  • C6H7N2Br
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Amines
  • Pyridines
  • Heterocyclic Compounds
  • Chemical Amines
  • Anilines, Amides & Amines
  • Bromine Compounds
  • Miscellaneous Compounds
  • Bromopyridines
  • Pyridine
  • Amines and Anilines
  • Heterocycles
  • C6Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Halopyridines
  • Bases & Related Reagents
  • Heterocyclic
  • Nucleotides
  • Boronic Acid