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1-Hydroxybenzotriazole

Product Name
1-Hydroxybenzotriazole
CAS No.
2592-95-2
Chemical Name
1-Hydroxybenzotriazole
Synonyms
HOBT;BENZOTRIAZOL-1-OL;HYDROXYBENZOTRIAZOLE;HBT;1-Benzotriazolol;1H-benzo[d][1,2,3]triazol-1-ol;N-HYDROXYBENZOTRIAZOLE;1-Hydroxybenzotrizole;Hydroxybenzotriazole Monohydrate;1H-Benzotriazol-1-ol
CBNumber
CB2420172
Molecular Formula
C6H5N3O
Formula Weight
135.12
MOL File
2592-95-2.mol
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1-Hydroxybenzotriazole Property

Melting point:
156-159°C
Boiling point:
149-150 °C
Density 
1 g/cm3
vapor pressure 
0.009Pa at 25℃
refractive index 
n20/D 1.488
Flash point:
95 °C
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
7.39±0.58(Predicted)
color 
White to off-white crystalline powder
Water Solubility 
4.201g/L at 29℃
Stability:
Stable, but possible risk of explosion if heated under confinement. Flammable.
LogP
0.146 at 25℃
CAS DataBase Reference
2592-95-2(CAS DataBase Reference)
NIST Chemistry Reference
1H-benzotriazole, 1-hydroxy-(2592-95-2)
EPA Substance Registry System
1H-Benzotriazole, 1-hydroxy- (2592-95-2)
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Safety

Hazard Codes 
F,Xi,T,E
Risk Statements 
11-5-36/38-36/37/38-36-20/21-61-2
Safety Statements 
16-33-7/9-26-45-53-15-36/37-35
RIDADR 
1325
RTECS 
DM1288000
HazardClass 
4.1
PackingGroup 
III
HS Code 
29339980
Toxicity
rat,LDLo,oral,5gm/kg (5000mg/kg),Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 679, 1992.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A7025
Product name
HOBt(anhydrous)
Packaging
100g
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
A7025
Product name
HOBt(anhydrous)
Packaging
250g
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
A7025
Product name
HOBt(anhydrous)
Packaging
500g
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018049
Product name
1-HYDROXY BENZOTRIAZOLE
Purity
95.00%
Packaging
5MG
Price
$550
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0018049
Product name
1-HYDROXY BENZOTRIAZOLE
Purity
95.00%
Packaging
0.5G
Price
$638
Updated
2021/12/16
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1-Hydroxybenzotriazole Chemical Properties,Usage,Production

Chemical Properties

white to light yellow powder

Uses

additive for oligonucleotide couplings and in racemization-free peptide couplings

Uses

1-Hydroxybenzotriazole (HOBT) is used in preparation method of carbon fiber/polyamide composite powder material for laser sintering.

Definition

ChEBI: 1-Hydroxybenzotriazole is a member of benzotriazoles.

Flammability and Explosibility

Not classified

Biological Activity

hydroxy benzotriazole, abbreviated hobt, is anorganic compoundthat is a derivative of benzotriazole. hobt, as a commercial product, is a white crystalline powder contains some water (~11.7% wt as the hobt monohydrate crystal). it is mainly used to suppress the racemization of single-enantiomerchiral molecules and to improve the efficiency ofpeptide synthesis. automated peptide synthesisinvolves the condensation of the amino group of protected amino acidswith the activated ester. hobt can be used to produce activated esters such as n-hydroxysuccinimide ester. these esters are insoluble and react with amines at ambient temperature to give amides [1]. hobt is also used for the synthesis of amides from carboxylic acidsaside from amino acids. these substrates may not be convertible to theacyl chlorides [2]. for instance amide derivatives of ionophoric antibiotics have been prepared in this way [3].

target

racemization

Purification Methods

Crystallise HOBt from aqueous EtOH or water. [Boyle & Jones J Chem Soc Perkin Trans II 160 1973, Tomita & Ikawa J Pharm Soc Jpn 75 449 1955, Beilstein 26 III/IV 95.]

References

[1]. knig w, geiger r. eineneuemethodezursynthese von peptiden: aktivierung der carboxylgruppemitdicyclohexylcarbodiimidunterzusatz von 1‐hydroxy‐benzotriazolen[j]. chemischeberichte, 1970, 103(3): 788-798.
[2]. myers a g, yang b h, chen h. transformation of pseudoephedrine amides into highly enantiomerically enriched aldehydes, alcohols, and ketones[j]. organic syntheses, 2000: 29-29.
[3]. owicki d, huczyński a, ratajczak-sitarz m, et al. structural and antimicrobial studies of a new n-phenylamide of monensin a complex with sodium chloride[j]. journal of molecular structure, 2009, 923(1): 53-59.

1-Hydroxybenzotriazole Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Hydrazine hydrate

Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID IBUTILIDE 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 2-AMINO-5-BROMOBENZAMIDE 6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE 6-bromo-2-methylquinazolin-4(3H)-one CeftazidiMe 3-CARBETHOXY-4-HYDROXYCOUMARIN Trandolapril trans-1,4-Dichloro-2-butene
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1-Hydroxybenzotriazole Suppliers

Austria 1 Canada 5 China 623 Europe 5 France 2 Germany 5 India 34 Israel 1 Japan 8 Norway 1 Slovakia 1 South Korea 4 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 20 United States 73 Global 789
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 13962195826
Fax
0512-68417696
Email
wuhao@highfine.com
Country
China
ProdList
499
Advantage
75
Hangzhou widechemical co.,ltd
Tel
571-85451942 13588030127
Email
sales@widechem.com.cn
Country
China
ProdList
10
Advantage
58
Zhejiang Yefeng Pharmaceutical Co., Ltd.
Tel
0579-86733319 13586958892
Email
office@wildwindchem.com
Country
China
ProdList
1
Advantage
58
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Medpep Co., Ltd
Tel
021-65566949 13901795941
Fax
86-21-51861665
Email
market@medpep.com
Country
China
ProdList
177
Advantage
66
Changzhou Red Sun Pharmaceutical Co., Ltd.
Tel
0519-85223897 13766960291
Fax
0519-85223902
Email
zjc@czredsunpharm.com
Country
China
ProdList
47
Advantage
58
Nanjing Yili Biotechnology Co., Ltd.
Tel
18795999647
Email
2853992905@qq.com
Country
China
ProdList
8134
Advantage
58
Shouguang Jiasheng Chemical Co., Ltd.
Tel
0536-7971999 18232719690
Fax
0536-7971999
Email
sgjiasheng@hotmail.com
Country
China
ProdList
388
Advantage
58
Gretel Chemical (Changzhou) Co., Ltd.
Tel
13606112397
Email
tang13606112397@163.com
Country
China
ProdList
216
Advantage
58
Hubei Ipodix Biotechnology Co.,Ltd.
Tel
027-19384116 19384116026
Email
2706668885@qq.com
Country
China
ProdList
4987
Advantage
58
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View Lastest Price from 1-Hydroxybenzotriazole manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
1-Hydroxy Benzotriazole 2592-95-2
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-Hydroxybenzotriazole 2592-95-2
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min HPLC
Supply Ability
5 Tons
Release date
2021-06-04
Hebei Weibang Biotechnology Co., Ltd
Product
1-Hydroxybenzotriazole 2592-95-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

2592-95-2, 1-HydroxybenzotriazoleRelated Search:

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