1-Hydroxybenzotriazole

Product Name: 1-Hydroxybenzotriazole
CAS No.: 2592-95-2
Chemical Name: 1-Hydroxybenzotriazole
Synonyms: HOBT;BENZOTRIAZOL-1-OL;HYDROXYBENZOTRIAZOLE;HBT;1-Benzotriazolol;1H-benzo[d][1,2,3]triazol-1-ol;N-HYDROXYBENZOTRIAZOLE;1-Hydroxybenzotrizole;Hydroxybenzotriazole Monohydrate;1H-Benzotriazol-1-ol
CBNumber: CB2420172
Molecular Formula: C6H5N3O
Formula Weight: 135.12
MOL File: 2592-95-2.mol

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1-Hydroxybenzotriazole Property

Melting point:: 156-159°C
Boiling point:: 149-150 °C
Density: 1 g/cm³
vapor pressure: 0.009Pa at 25℃
refractive index: n20/D 1.488
Flash point:: 95 °C
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 7.39±0.58(Predicted)
color: White to off-white crystalline powder
Water Solubility: 4.201g/L at 29℃
Stability:: Stable, but possible risk of explosion if heated under confinement. Flammable.
LogP: 0.146 at 25℃
CAS DataBase Reference: 2592-95-2(CAS DataBase Reference)
NIST Chemistry Reference: 1H-benzotriazole, 1-hydroxy-(2592-95-2)
EPA Substance Registry System: 1H-Benzotriazole, 1-hydroxy- (2592-95-2)

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Safety

Hazard Codes: F,Xi,T,E
Risk Statements: 11-5-36/38-36/37/38-36-20/21-61-2
Safety Statements: 16-33-7/9-26-45-53-15-36/37-35
RIDADR: 1325
RTECS: DM1288000
HazardClass: 4.1
PackingGroup: III
HS Code: 29339980
Toxicity: rat,LDLo,oral,5gm/kg (5000mg/kg),Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 679, 1992.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H228Flammable solid
Precautionary statements: P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A7025
Product name: HOBt(anhydrous)
Packaging: 100g
Price: $60
Updated: 2021/12/16

ApexBio Technology

Product number: A7025
Product name: HOBt(anhydrous)
Packaging: 250g
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: A7025
Product name: HOBt(anhydrous)
Packaging: 500g
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0018049
Product name: 1-HYDROXY BENZOTRIAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0018049
Product name: 1-HYDROXY BENZOTRIAZOLE
Purity: 95.00%
Packaging: 0.5G
Price: $638
Updated: 2021/12/16

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1-Hydroxybenzotriazole Chemical Properties,Usage,Production

Chemical Properties

white to light yellow powder

Uses

additive for oligonucleotide couplings and in racemization-free peptide couplings

Uses

1-Hydroxybenzotriazole (HOBT) is used in preparation method of carbon fiber/polyamide composite powder material for laser sintering.

Definition

ChEBI: 1-Hydroxybenzotriazole is a member of benzotriazoles.

Flammability and Explosibility

Not classified

Biological Activity

hydroxy benzotriazole, abbreviated hobt, is anorganic compoundthat is a derivative of benzotriazole. hobt, as a commercial product, is a white crystalline powder contains some water (~11.7% wt as the hobt monohydrate crystal). it is mainly used to suppress the racemization of single-enantiomerchiral molecules and to improve the efficiency ofpeptide synthesis. automated peptide synthesisinvolves the condensation of the amino group of protected amino acidswith the activated ester. hobt can be used to produce activated esters such as n-hydroxysuccinimide ester. these esters are insoluble and react with amines at ambient temperature to give amides [1]. hobt is also used for the synthesis of amides from carboxylic acidsaside from amino acids. these substrates may not be convertible to theacyl chlorides [2]. for instance amide derivatives of ionophoric antibiotics have been prepared in this way [3].

target

racemization

Purification Methods

Crystallise HOBt from aqueous EtOH or water. [Boyle & Jones J Chem Soc Perkin Trans II 160 1973, Tomita & Ikawa J Pharm Soc Jpn 75 449 1955, Beilstein 26 III/IV 95.]

References

[1]. knig w, geiger r. eineneuemethodezursynthese von peptiden: aktivierung der carboxylgruppemitdicyclohexylcarbodiimidunterzusatz von 1‐hydroxy‐benzotriazolen[j]. chemischeberichte, 1970, 103(3): 788-798.
[2]. myers a g, yang b h, chen h. transformation of pseudoephedrine amides into highly enantiomerically enriched aldehydes, alcohols, and ketones[j]. organic syntheses, 2000: 29-29.
[3]. owicki d, huczyński a, ratajczak-sitarz m, et al. structural and antimicrobial studies of a new n-phenylamide of monensin a complex with sodium chloride[j]. journal of molecular structure, 2009, 923(1): 53-59.

1-Hydroxybenzotriazole Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution Hydrazine hydrate

Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID IBUTILIDE 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 2-AMINO-5-BROMOBENZAMIDE 6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE 6-bromo-2-methylquinazolin-4(3H)-one CeftazidiMe 3-CARBETHOXY-4-HYDROXYCOUMARIN Trandolapril trans-1,4-Dichloro-2-butene

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1-Hydroxybenzotriazole Suppliers

Austria 1 Canada 5 China 624 Europe 5 France 2 Germany 5 India 34 Israel 1 Japan 8 Norway 1 Slovakia 1 South Korea 4 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 20 United States 73 Global 790

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View Lastest Price from 1-Hydroxybenzotriazole manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 1-Hydroxy Benzotriazole 2592-95-2
Price: US $75.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Hydroxybenzotriazole 2592-95-2
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min HPLC
Supply Ability: 5 Tons
Release date: 2021-06-04

Hebei Weibang Biotechnology Co., Ltd

Product: 1-Hydroxybenzotriazole 2592-95-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

2592-95-2, 1-HydroxybenzotriazoleRelated Search:

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1-Hydroxybenzotriazole 〔HBT〕

1-HYDROXYLBENZOTRIAZOLE

1-HYDROXYBENZOTRIAZOL

1-HYDROXYBENZOTRIAZOLE

1-hydroxybenzotriazole anhydrous

1-HYDROXY-1-H-BENZOTRIAZOLE

1-HYDROXY-1,2,3-BENZOTRIAZOLE

1-HOB

1H-BENZOTRIAZOLE, 1-HYDROXY-

HBT

HYDROXYBENZOTRIAZOLE

HOBTA

HOBT

BENZOTRIAZOL-1-OL

1H-1,2,3-Benzotriazol-1-ol

1H-Benzotriazol-1-ol

Benzazimidol

1-Hydroxybenzotrizole

N-HYDROXYBENZOTRIAZOLE

HOBt(anhydrous)

1-Hydroxybenzotriazole,98%

1-Hydroxybenzotriazole/1-Methyl-2-pyrrolidinone,for peptide synthesis,2 bottles kit for 1.

1H-1,2,3-benzotriazole, 1-hydroxy-

Hobt,1-Hydroxybenzotriazole

1-Benzotriazolol

1H-1,2,3-Benzotriazol-1-ol (wet with 14% water)

Hydroxybenzotriazole Monohydrate

1-hydroxy-triazole (HOBT)

1-Hydroxybenzotriazole ,99%

1-Hydroxybenzotriazole/N,N-Dimethylformamide, 2 bottles kit for 0.5M solution, for peptide synthesis

1-HYDROXYBENZOTRIAZOLE HYDRATE, 15 WT. % SOLUTION IN DIMETHYLFORMAMIDE

1-Hydroxybenzotriazo

5-Hydroxy-1,3-benzox

N-Hydroxybenzotrizole Anhydrate

N-Hydroxybenzotrizole

1-Hydroxybenzotriazole hydrate [ or ] HOBT

Benzotriazol-1-ol 1-hydroxy-1H-Benzotriazole

500G/1KG/5KGS

1H-benzo[d][1,2,3]triazol-1-ol

HOBt)1-Hydroxybenzotr

HOBT, 1-Hydroxybenzotriazole Monohydrate

N-Hydroxybenzotriazole(HOBT)

1-HYDROXYBENZOTRIAZOLE SOLUTION &

1-HYDROXYBENZOTRIAZOLE SOLUTION 0.2 M IN DMSO/NMP

1-HYDROXYBENZOTRIAZOLE CONTAINS <5% WA&

Hobt(1-Hydroxybenzotrizole)

1-Hydroxybenzotriazole, anhydrous (< 1% water), 98%

1-Oxy-benztriazol

HOBt, Benzotriazol-1-ol

1,2,3-benzotriazol-1-ol

1-Hydroxyl-1H-benzotriazole,monohydrate

1-hyroxybenzotriazole

1H-1,2,3-BENZOTRIAZOL-1-OL(1-HOB)

HOBT N-HYDROXYBENZOTRIZOLE

1-Hydroxybenzotriazole (HOBt) anhydrous

1-Hydroxybenzotriazole anhydrous (HOBt)

1-HYDROXIBENZOTRIAZOL ANHYDROUS

HOBT (anh)