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DIAMINE OXIDASE

Product Name
DIAMINE OXIDASE
CAS No.
9001-53-0
Chemical Name
DIAMINE OXIDASE
Synonyms
EC 1.4.3.6;Histaminase;DIAMINE OXIDASE;Oxidase, diamine;EC NUMBER: 1.4.3.6;DIAMINE OXIDASE USP/EP/BP;Native Porcine Diamine Oxidase;amine oxidase, copper-containing;Diamine oxidase from Pea Sprouts;ENZYME COMMISSION NUMBER: 1.4.3.6
CBNumber
CB2440996
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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DIAMINE OXIDASE Property

storage temp. 
-20°C
solubility 
100 mM sodium phosphate buffer, pH 7.2: soluble10mg/mL
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D7876
Product name
Diamine Oxidase from porcine kidney
Purity
≥0.05 unit/mg solid
Packaging
1g
Price
$289
Updated
2024/03/01
Sigma-Aldrich
Product number
D7876
Product name
Diamine Oxidase from porcine kidney
Purity
≥0.05 unit/mg solid
Packaging
5g
Price
$877
Updated
2024/03/01
Sigma-Aldrich
Product number
D7876
Product name
Diamine Oxidase from porcine kidney
Purity
≥0.05 unit/mg solid
Packaging
250mg
Price
$90.1
Updated
2024/03/01
Sigma-Aldrich
Product number
D7876
Product name
Diamine Oxidase from porcine kidney
Purity
≥0.05 unit/mg solid
Packaging
10g
Price
$1540
Updated
2024/03/01
Usbiological
Product number
365935
Product name
Diamine Oxidase
Packaging
96Tests
Price
$824
Updated
2021/12/16
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DIAMINE OXIDASE Chemical Properties,Usage,Production

Uses

Diamine Oxidase from porcine kidney has been used in the construction of histamine biosensor.

Definition

An enzyme occurring in the animal digestive system; it converts histidine to histamine.

Biological Functions

Diamine oxidase attacks both diamines and histamine in much the same way that MAO attacks monoamines, forming aldehydes. This enzyme is inhibited by carbonyl-blocking reagents and produces hydrogen peroxide, supporting the role of pyridoxal phosphate and the flavin prosthetic groups in the catalytic action of the enzyme. Diamine oxidase is recovered in the supernatant after centrifugation and removal of particulate matter. It is present in kidneys, intestines, liver, lung, and nervous tissue. It limits the biological effects of histamine and the polymethylene amines putrescine and cadaverine. It also attacks monoamines, but at a higher substrate concentration.Plasma amine oxidases are in blood plasma of mammals and include spermine oxidase, which deaminates spermine and other polyamines.

General Description

Diamine oxidase from porcine kidney is a homodimer consisting of two equal subunits with a molecular weight of 87 kDa each. Each subunit contains one molecule of pyridoxal phosphate and one atom of copper. The molecular mass of the enzyme is found to be 170 kDa. The enzyme is a glycoprotein containing 5% hexose, 3.3% glucosamine, 2.6% N-acetylglucosamine, and 0.25% N-acetylneuraminic acid. The enzyme exhibits a high affinity for concanavalin A. Optimum pH with cadverine and histamine as substrates is found to be 6.3-7.4.

Biochem/physiol Actions

Diamine Oxidase catalyzes the oxidation of monoamines, diamines, and histamine to aldehydes, ammonia, and hydrogen peroxide. The enzyme is classified as a copper amine oxidase and it is a key enzyme in nitrogen metabolism. Diamine oxidase is inhibited by diethyldithiocarbamate, phenylhydrazine, semicarbazide, cyanide, isonicotinic acid hydrazide.

DIAMINE OXIDASE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIAMINE OXIDASE Suppliers

Shanghai Macklin Biochemical Co.,Ltd.
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China
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Shaanxi Dideu Medichem Co. Ltd
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4008-099-669
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Henan Fengda Chemical Co., Ltd
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Shaanxi LonierHerb Bio Technology Co Ltd
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Rhenbo (Shanghai) Biochemical Technology Co., Ltd.
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View Lastest Price from DIAMINE OXIDASE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
DIAMINE OXIDASE 9001-53-0
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-08-30

9001-53-0, DIAMINE OXIDASERelated Search:


  • AMINE: OXYGEN OXIDOREDUCTASE[DEAMINATING] [PYRIDOXAL-CONTAINING]
  • EC 1.4.3.6
  • EC NUMBER: 1.4.3.6
  • ENZYME COMMISSION NUMBER: 1.4.3.6
  • DIAMINE OXIDASE
  • amine oxidase, copper-containing
  • diamine oxidase from porcine kidney
  • Oxidase, diamine
  • Histaminase
  • Diamine Oxidase from porcine kidney,Amine:oxygen oxidoreductase (deaminating) (pyridoxal-containing)
  • Native Porcine Diamine Oxidase
  • Native Arthrobacter sp. Tyramine Oxidase
  • Native Plant origin Diamine Oxidase
  • DIAMINE OXIDASE USP/EP/BP
  • Diamine oxidase from Pea Sprouts
  • 9001-53-0
  • BioChemical
  • Metabolomics
  • General Metabolic Enzymes
  • General Metabolic Enzymes A-H