SPDP

Product Name: SPDP
CAS No.: 68181-17-9
Chemical Name: SPDP
Synonyms: SPDP;SPDP NHS ester;SPDP Crosslinker;3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU;SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE;N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE;3-(Pyridin-2-yldisulfanyl)-propionic acid-OS;3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU;N-succinimidyl-3-(2-pyridyldithiol)propionate;N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
CBNumber: CB2446059
Molecular Formula: C12H12N2O4S2
Formula Weight: 312.36
MOL File: 68181-17-9.mol

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SPDP Property

Melting point:: 84-86 °C(lit.)
Boiling point:: 465.9±55.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: acetone: 50 mg/mL
form: powder
pka: 1.76±0.19(Predicted)
color: White to Light Yellow
BRN: 1548137
Stability:: Hygroscopic, Moisture Sensitive
InChIKey: JWDFQMWEFLOOED-UHFFFAOYSA-N
CAS DataBase Reference: 68181-17-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 1-10
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P3415
Product name: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
Purity: ≥95%, powder
Packaging: 5mg
Price: $67.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: P3415
Product name: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
Purity: ≥95%, powder
Packaging: 25mg
Price: $205
Updated: 2024/03/01

TCI Chemical

Product number: S0819
Product name: N-Succinimidyl 3-(2-Pyridyldithio)propionate
Packaging: 250MG
Price: $174
Updated: 2024/03/01

TCI Chemical

Product number: S0819
Product name: N-Succinimidyl 3-(2-Pyridyldithio)propionate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $390
Updated: 2024/03/01

TCI Chemical

Product number: S0819
Product name: N-Succinimidyl 3-(2-Pyridyldithio)propionate
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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SPDP Chemical Properties,Usage,Production

Description

SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells.

Chemical Properties

White Solid

Uses

Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds.

Uses

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.

Uses

A heterobifunctional cross-linker

General Description

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.

SPDP Preparation Products And Raw materials

Raw materials

Preparation Products

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SPDP Suppliers

Australia 1 Belgium 1 Canada 3 China 144 Europe 2 France 1 Germany 4 India 7 Japan 4 Switzerland 3 United Kingdom 9 United States 54 USA 1 Global 234

Apollo Scientific Ltd

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Country: United Kingdom
ProdList: 4521
Advantage: 58

Discovery Fine Chemicals Ltd.

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Country: United Kingdom
ProdList: 530
Advantage: 58

Hexonsynth

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Country: United Kingdom
ProdList: 145
Advantage: 58

Biosynth Carbosynth

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Country: United Kingdom
ProdList: 2598
Advantage: 58

Apollo Scientific Ltd.

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Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

CARBONE SCIENTIFIC CO.,LTD

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Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

MOLEKULA Ltd.

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Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

UK GREEN SCIENTIFIC CO.,LIMITED

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Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

VWR International

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Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

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View Lastest Price from SPDP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: SPDP-NHS ester 68181-17-9
Price: US $0.00/g
Min. Order: 10g
Purity: >99.00%
Supply Ability: 10g
Release date: 2024-03-27

Career Henan Chemical Co

Product: SPDP 68181-17-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-10

68181-17-9, SPDPRelated Search:

SPDP-PEG4-acid SPDP-PEG6-NHS ester SPDP-PEG1-NHS ester SPDP-PEG3-COOH SPDP-PEG2-NHS ester SPDP-PEG6-acid SPDP-PEG4-NHS ester SPDP-PEG3-NHS ester SPDP-PEG8-acid SPDP-PEG8-NHS ester N-Hydroxysuccinimide 2-Pyridinethione Pyridinium acetate N,N-Diethylhydroxylamine N-Acetoxysuccinimide Acetohydroxamic acid Succinimide Argon

3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-HYDROXY-SUCCINIMIDE ESTER

3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER

3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU

succinimidyl3-(2-pyridyldithio)propionate(spdp)

SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE

SPDP

N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE

N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE

1-[1-oxo-3-(2-pyridyldithio)propoxy]pyrrolidine-2,5-dione

2,5-Pyrrolidinedione, 1-1-oxo-3-(2-pyridinyldithio)propoxy-

3-(2-PYRIDYLDITHIO)-PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE

3-(Pyridin-2-yldisulfanyl)-propionic acid-OS

3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU

3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM

3-(Pyridin-2-yldisulfanyl)propionic acid N-Hydroxy succinimide ester

3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester SPDP

3-(Pyridin-2-yldisulfanyl)-propionic acid-OSu, SPDP

3-(2-Pyridylthio)propionic acid N-hydroxysucciniMide ester

<i>N</i>-Succinimidyl 3-(2-Pyridyldithio)propionate

SPDP Crosslinker

SPDP NHS ester

2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate

3-(2-Pyridyldithio)propionic acidN-hydroxyuccinimide ester≥ 97% (HPLC)

N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP

1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione

3-(2-Pyridyldithio)propionic acid 2,5-dioxo-1-pyrrolidinyl ester

3-[(2-Pyridinyl)dithio]propionic acid succinimidyl ester

3-[(2-Pyridyl)dithio]propionic acid succinimidyl ester

N-[3-(2-Pyridyldithio)propionyloxy]succinimide

2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoate

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester（SPDP）

N-Succinimidyl3-(Pyridin-2yldithio)-propionate(SPDP)

N-Succinimidyl3-(2-Pyridyldithio)propionate&gt

Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester

3-(2-Pyridyldithio)propionic Acid N-Hydroxysuccinimide Ester (SPDP Crosslinker) extrapure, 95%

2,5-Dioxo-1-pyrrolidinyl 3-(2-Pyridyldisulfanyl)propanoate

N-succinimidyl-3-(2-pyridyldithiol)propionate

68181-17-9

C12H12N2O4S2

BioChemical

Heterobifunctional Cross-Linking Reagents

Crosslinking

Protein Modification

Proteomics

Proteomics and Protein Expression

Heterobifunctional Crosslinker

heteroXlink

Cross Linking Reagents

Nitric Oxide Reagents