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SPDP

Product Name
SPDP
CAS No.
68181-17-9
Chemical Name
SPDP
Synonyms
SPDP;SPDP NHS ester;SPDP Crosslinker;3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU;SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE;N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE;3-(Pyridin-2-yldisulfanyl)-propionic acid-OS;3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU;N-succinimidyl-3-(2-pyridyldithiol)propionate;N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
CBNumber
CB2446059
Molecular Formula
C12H12N2O4S2
Formula Weight
312.36
MOL File
68181-17-9.mol
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SPDP Property

Melting point:
84-86 °C(lit.)
Boiling point:
465.9±55.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
acetone: 50 mg/mL
form 
powder
pka
1.76±0.19(Predicted)
color 
White to Light Yellow
BRN 
1548137
Stability:
Hygroscopic, Moisture Sensitive
InChIKey
JWDFQMWEFLOOED-UHFFFAOYSA-N
CAS DataBase Reference
68181-17-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
1-10
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P3415
Product name
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
Purity
≥95%, powder
Packaging
5mg
Price
$67.1
Updated
2024/03/01
Sigma-Aldrich
Product number
P3415
Product name
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
Purity
≥95%, powder
Packaging
25mg
Price
$205
Updated
2024/03/01
TCI Chemical
Product number
S0819
Product name
N-Succinimidyl 3-(2-Pyridyldithio)propionate
Packaging
250MG
Price
$174
Updated
2024/03/01
TCI Chemical
Product number
S0819
Product name
N-Succinimidyl 3-(2-Pyridyldithio)propionate
Purity
>98.0%(HPLC)
Packaging
1g
Price
$390
Updated
2024/03/01
TCI Chemical
Product number
S0819
Product name
N-Succinimidyl 3-(2-Pyridyldithio)propionate
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$75
Updated
2021/12/16
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SPDP Chemical Properties,Usage,Production

Description

SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells.

Chemical Properties

White Solid

Uses

Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds.

Uses

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.

Uses

A heterobifunctional cross-linker

General Description

3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.

reaction suitability

reagent type: cross-linking reagent

SPDP Preparation Products And Raw materials

Raw materials

Preparation Products

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SPDP Suppliers

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View Lastest Price from SPDP manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
SPDP-NHS ester 68181-17-9
Price
US $0.00/g
Min. Order
10g
Purity
>99.00%
Supply Ability
10g
Release date
2024-03-27
Career Henan Chemical Co
Product
SPDP 68181-17-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-10

68181-17-9, SPDPRelated Search:

SPDP-PEG4-acid SPDP-PEG6-NHS ester SPDP-PEG1-NHS ester SPDP-PEG3-COOH SPDP-PEG2-NHS ester SPDP-PEG6-acid SPDP-PEG4-NHS ester SPDP-PEG3-NHS ester SPDP-PEG8-acid SPDP-PEG8-NHS ester N-Hydroxysuccinimide 2-Pyridinethione Pyridinium acetate N,N-Diethylhydroxylamine N-Acetoxysuccinimide Acetohydroxamic acid Succinimide Argon

  • 3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-HYDROXY-SUCCINIMIDE ESTER
  • 3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER
  • 3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU
  • succinimidyl3-(2-pyridyldithio)propionate(spdp)
  • SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE
  • SPDP
  • N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
  • N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE
  • 1-[1-oxo-3-(2-pyridyldithio)propoxy]pyrrolidine-2,5-dione
  • 2,5-Pyrrolidinedione, 1-1-oxo-3-(2-pyridinyldithio)propoxy-
  • 3-(2-PYRIDYLDITHIO)-PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
  • 3-(Pyridin-2-yldisulfanyl)-propionic acid-OS
  • 3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU
  • 3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM
  • 3-(Pyridin-2-yldisulfanyl)propionic acid N-Hydroxy succinimide ester
  • 3-(2-Pyridyldithio)propionic Acid N-Succinimidyl Ester SPDP
  • 3-(Pyridin-2-yldisulfanyl)-propionic acid-OSu, SPDP
  • 3-(2-Pyridylthio)propionic acid N-hydroxysucciniMide ester
  • <i>N</i>-Succinimidyl 3-(2-Pyridyldithio)propionate
  • SPDP Crosslinker
  • SPDP NHS ester
  • 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate
  • 3-(2-Pyridyldithio)propionic acidN-hydroxyuccinimide ester≥ 97% (HPLC)
  • N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP
  • 1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione
  • 3-(2-Pyridyldithio)propionic acid 2,5-dioxo-1-pyrrolidinyl ester
  • 3-[(2-Pyridinyl)dithio]propionic acid succinimidyl ester
  • 3-[(2-Pyridyl)dithio]propionic acid succinimidyl ester
  • N-[3-(2-Pyridyldithio)propionyloxy]succinimide
  • 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoate
  • 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester（SPDP）
  • N-Succinimidyl3-(Pyridin-2yldithio)-propionate(SPDP)
  • N-Succinimidyl3-(2-Pyridyldithio)propionate&gt
  • Propanoic acid, 3-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester
  • 3-(2-Pyridyldithio)propionic Acid N-Hydroxysuccinimide Ester (SPDP Crosslinker) extrapure, 95%
  • 2,5-Dioxo-1-pyrrolidinyl 3-(2-Pyridyldisulfanyl)propanoate
  • N-succinimidyl-3-(2-pyridyldithiol)propionate
  • SPDP crosslinker, Cysteine and primary amine reactive short chain crosslinker
  • 68181-17-9
  • C12H12N2O4S2
  • BioChemical
  • Heterobifunctional Cross-Linking Reagents
  • Crosslinking
  • Protein Modification
  • Proteomics
  • Proteomics and Protein Expression
  • Heterobifunctional Crosslinker
  • heteroXlink
  • Cross Linking Reagents
  • Nitric Oxide Reagents