ChemicalBook > CAS DataBase List > 2-Amino-4-chloro-6-methylpyrimidine

2-Amino-4-chloro-6-methylpyrimidine

Product Name: 2-Amino-4-chloro-6-methylpyrimidine
CAS No.: 5600-21-5
Chemical Name: 2-Amino-4-chloro-6-methylpyrimidine
Synonyms: AM;4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE;ACLP;ProAM-N20;prepn. AM;Rhod-4™AKOS MSC-0728;Cal-630™Fura-10™AM (inhibitor)
CBNumber: CB2458081
Molecular Formula: C5H6ClN3
Formula Weight: 143.57
MOL File: 5600-21-5.mol

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2-Amino-4-chloro-6-methylpyrimidine Property

Melting point:: 183-186 °C (lit.)
Boiling point:: 234.32°C (rough estimate)
Density: 1.2986 (rough estimate)
refractive index: 1.6000 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: acetic acid: soluble50mg/mL, clear, colorless to faintly yellow
pka: 4.26±0.10(Predicted)
form: Solid
color: White to Off-White
biological source: rabbit
Water Solubility: Insoluble in water.
BRN: 114297
InChI: InChI=1S/C5H6ClN3/c1-3-2-4(6)9-5(7)8-3/h2H,1H3,(H2,7,8,9)
InChIKey: NPTGVVKPLWFPPX-UHFFFAOYSA-N
SMILES: C1(N)=NC(C)=CC(Cl)=N1
CAS DataBase Reference: 5600-21-5(CAS DataBase Reference)
NIST Chemistry Reference: 2-Amino-4-chloro-6-methylpyrimidine(5600-21-5)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 22-24/25-37/39-26-36
WGK Germany: 3
RTECS: UV6329600
HazardClass: IRRITANT, AVOID SKIN CONTACT
HS Code: 29335995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 122882
Product name: 2-Amino-4-chloro-6-methylpyrimidine
Purity: 97%
Packaging: 5g
Price: $23.38
Updated: 2025/07/31

Sigma-Aldrich

Product number: SAB1303888
Product name: ANTI-ADM (CENTER) antibody produced in rabbit
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 400 μL
Price: $496
Updated: 2025/07/31

Sigma-Aldrich

Product number: 122882
Product name: 2-Amino-4-chloro-6-methylpyrimidine
Purity: 97%
Packaging: 25g
Price: $88.9
Updated: 2025/07/31

TCI Chemical

Product number: A1088
Product name: 2-Amino-4-chloro-6-methylpyrimidine
Purity: >98.0%(T)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: A1088
Product name: 2-Amino-4-chloro-6-methylpyrimidine
Purity: >98.0%(T)
Packaging: 25g
Price: $76
Updated: 2025/07/31

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2-Amino-4-chloro-6-methylpyrimidine Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT YELLOW NEEDLE-LIKE CRYST. POWDER

Uses

2-Amino-4-chloro-6-methylpyrimidine was used to study the influence of chlorine substitution in pyrimidine ring on proton donor ability of amino group in 2-aminopyrimidine.

Definition

ChEBI: An aminopyrimidine compound having its amino group at position 2 and chloro and methyl substituents at positions 4 and 6 respectively.

General Description

2-Amino-4-chloro-6-methylpyrimidine is a nitification inhibitor.

Synthesis

3977-29-5

5600-21-5

General procedure for the synthesis of 2-amino-4-chloro-6-methylpyrimidine from 2-amino-4-hydroxy-6-methylpyrimidine: 6 g of 2-amino-4-hydroxy-6-methylpyrimidine (IV) was mixed with 35 mL of freshly distilled phosphorous trichloride and the reaction was carried out by refluxing the mixture until it was homogeneous. Upon completion of the reaction, the excess phosphorous trichloride was removed under vacuum. The reaction mixture was cooled and the residue was mixed with ice water and the pH was adjusted with 25% ammonia to 8. The resulting suspension was filtered and the precipitate was washed with water. The crude product was recrystallized from 50% ethanol and dried to constant weight at constant temperature. A final 3.7 g of the target product (54% yield) was obtained with a melting point of 188°C (literature value 182-183°C [7]) and a thin-layer chromatographic Rf value of 0.79 (Expander D). Elemental analysis results: 41.74% C, 4.05% H, 29.35% N. Theoretically calculated values for the molecular formula C5H6ClN3: C 41.83%, H 4.21%, N 29.27%.

Purification Methods

Recrystallise it from EtOH. [Beilstein 24 H 84.]

References

[1] Russian Journal of General Chemistry, 2015, vol. 85, # 1, p. 79 - 87
[2] Zhurnal Obshchei Khimii, 2015, vol. 85, # 1, p. 79 - 87,9

2-Amino-4-chloro-6-methylpyrimidine Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium Phosphorus oxitrichloride Guanidine hydrochloride Diethyl ether

Preparation Products

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View Lastest Price from 2-Amino-4-chloro-6-methylpyrimidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-02

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5
Price: US $9.90/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: 4-Chloro-6-methyl-2-pyrimidinamine 5600-21-5
Price: US $9.90/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-24

5600-21-5, 2-Amino-4-chloro-6-methylpyrimidineRelated Search:

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TIMTEC-BB SBB004134

2-amino-4-chloro-6-methyl-pyrimidin

2-Pyrimidinamine, 4-chloro-6-methyl-

2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE (ACLP)

2-Amino-4-chloro-6-methylpyrimidine ,97%

4-Chloro-6-methyl-pyrimidine-2-amine

2-Amino-4-chloro-6-methylpyrimidine,98%

AMR human cell line

ANTI-ADM (CENTER) antibody produced in rabbit

Proadrenomedullin N-20 terminal peptide

ProAM N-terminal 20 peptide

ProAM-N20

2-AMINO-4-CHLORO-6-METHYLPYRIMIDINE

2-AMINO-4-CHLORO-6-METHYL-PYRIMIDINE*CRY STALLINE

Amino-4-chloro-6-methylpyrimidine

2-Pyrimidinamine, 4-chloro-6-methyl- (9CI)

2-amino-4-chloro-methoxypyrimidine

4-chloro-6-methyl-2-pyrimidinamin

4-Chloro-6-methyl-2-pyrimidinamine

4-CHLORO-6-METHYLPYRIMIDIN-2-AMINE

4-CHLORO-6-METHYL-PYRIMIDIN-2-YLAMINE

4-CHLORO-6-METHYL-2-PYRIMIDINYLAMINE

AKOS MSC-0728

ACLP

AM (inhibitor)

AM (Nitrification inhibitor)

AM (pesticide)

am(nitrificationinhibitor)

prepn. AM

Pyrimidine, 2-amino-4-chloro-6-methyl-

ASISCHEM C58325

4-Chloro-6-methyl-pyrimidinamine

2-Amino-4-chloro-6-methylpyrimidine &gt

2-Amino-4-chloro-6-methylpyrimidine ISO 9001：2015 REACH

Cal-630&trade

Fura-8FF&trade

Rhod-4&trade

Fura-10&trade

5600-21-5

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