FK BINDING PROTEIN
Description Source Background- Product Name
- FK BINDING PROTEIN
- CAS No.
- 131144-19-9
- Chemical Name
- FK BINDING PROTEIN
- Synonyms
- FKBP1;PKC12;PKCI2;FKBP25;FKBP1A;fkbp-12;FKBP-1A;Rotamase;Calstabin-1;FKBP3 human
- CBNumber
- CB2486536
- Formula Weight
- 0
- MOL File
- Mol file
FK BINDING PROTEIN Property
- storage temp.
- 2-8°C
- form
- liquid
- biological source
- rabbit
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SAB1303643
- Product name
- ANTI-FKBP12 (CENTER) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μL
- Price
- $496
- Updated
- 2025/07/31
- Product number
- SRP6091
- Product name
- FKBP1a/FKBP12 human
- Purity
- recombinant, expressed in <I>E. coli</I>, ≥95% (SDS-PAGE)
- Packaging
- 100 μg
- Price
- $532
- Updated
- 2025/07/31
- Product number
- SRP6091
- Product name
- FKBP1a/FKBP12 human
- Purity
- recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
- Packaging
- 100μG
- Price
- $516
- Updated
- 2024/03/01
- Product number
- SRP6093
- Product name
- FKBP3 human
- Purity
- recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
- Packaging
- 100μG
- Price
- $486
- Updated
- 2023/01/07
- Product number
- 517213
- Product name
- FK506 Binding Protein 1A
- Packaging
- 96Tests
- Price
- $981
- Updated
- 2021/12/16
FK BINDING PROTEIN Chemical Properties,Usage,Production
Biological Activity
FKFBP1A (FK506-binding protein 1A) is a peptidyl-prolyl cis-trans isomerase. It interacts with the ryanodine receptor (RyR1) and helps in maintaining intracellular Ca2+ homeostasis. It is also involved in protein folding, cell cycle and protein trafficking. In neurodegenerative diseases, FKFBP1A is dysregulated and might be associated with the pathogenesis. In human cell lines, it controls the localization and processing of amyloid precursor protein, and thus might be involved in the pathogenesis of Alzheimer′s disease. FKFBP1A is also involved in Huntington′s disease. It plays a role in the structural properties and proteotoxicity of mHTT (mutant huntingtin) aggregates.
Description
FKBP3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 224 amino acids (1-224 a.a.) and having a molecular mass of 25.1 kDa. FKBP3 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.
FK BINDING PROTEIN Preparation Products And Raw materials
Raw materials
Preparation Products
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