Nicardipine

ChemicalBook > CAS DataBase List > Nicardipine

Product Name: Nicardipine
CAS No.: 55985-32-5
Chemical Name: Nicardipine
Synonyms: NICARDIPINE;NicardipineBase;Nicardipine USP/EP/BP;Nicardipine Hcl 54527-84-3 / Base;benzylmethylamino)ethylmethylester;NICARDIPINE 20% SR, 33% SR PELLETS;Nicardipine (base and/or unspecified salts);2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate;Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CBNumber: CB2487861
Molecular Formula: C26H29N3O6
Formula Weight: 479.52
MOL File: 55985-32-5.mol

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Nicardipine Property

Melting point:: 136-138 °C
Boiling point:: 603.4±55.0 °C(Predicted)
Density: 1.230±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Dichloromethane; Methanol
form: Solid
pka: 7.30±0.50(Predicted)
color: Yellow
CAS DataBase Reference: 55985-32-5(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: N394503
Product name: Nicardipine
Packaging: 500mg
Price: $485
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611926
Product name: Nicardipine
Packaging: 25g
Price: $598.4
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009043
Product name: NICARDIPINE
Purity: 95.00%
Packaging: 50G
Price: $3265.94
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BN166182
Product name: Nicardipine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009043
Product name: NICARDIPINE
Purity: 95.00%
Packaging: 100MG
Price: $328.65
Updated: 2021/12/16

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Nicardipine Chemical Properties,Usage,Production

Originator

Nicodel,Mitsui,Japan,1981

Uses

Vasodilator.

Uses

It is used for arterial hypertension, chronic, stable angina pectoris, preventing angina pectoris, and for ischemic-type abnormalities of brain blood flow.

Uses

Nicardipine is a dihydropyridine calcium channel blocker. Antianginal; antihypertensive. Neuroprotective & Neuroresearch products.

Definition

ChEBI: Nicardipine is a racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. It has a role as an antihypertensive agent, a calcium channel blocker, a vasodilator agent and an autophagy inhibitor. It contains a (S)-nicardipine and a (R)-nicardipine.

Manufacturing Process

A mixture of 4.98 g of acetoacetic acid N-benzyl-N-methylaminoethyl ester, 2.3 g of β-aminocrotonic acid methyl ester, and 3 g of m-nitrobenzaldehyde was stirred for 6 hours at 100°C in an oil bath. The reaction mixture was subjected to a silica gel column chromatography (diameter 4 cm and height 25 cm) and then eluted with a 20:1 mixture of chloroform and acetone. The effluent containing the subject product was concentrated and checked by thin layer chromatography. The powdery product thus obtained was dissolved in acetone and after adjusting the solution with an ethanol solution saturated with hydrogen chloride to pH 1-2, the solution was concentrated to provide 2 g of 2,6-dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 3-methylester-5-β-(N-benzyl-N-methylamino)ethyl ester hydrochloride. The product thus obtained was then crystallized from an acetone mixture, melting point 136°C to 140°C (decomposed).

brand name

Cardene(PDL Biopharma); Cardene (Roche).

Therapeutic Function

Vasodilator

Mechanism of action

Nicardipin relaxes smooth musculature of vessels, lowers resistance of coronary and peripheral vessels, increases blood flow in vessels of the brain, causes a moderate and stable hypotensive effect, and reduces the myocardial need for oxygen.

Synthesis

Nicardipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl-2-[(methylphenylmethyl)- amino]ethyl ester 3,5-pirididincarboxylic acid (19.3.7), is synthesized in a manner analogous to the synthesis of nifedipine, the only difference being that in the Hantsch synthesis, two different |?-dicarbonyl compounds are used simultaneously with o-nitrobenzaldehyde. During this, one of these in the enamine form of acetoacetic ester is simultaneously used as an amine component. A heterocyclization reaction is accomplished by reacting, the methyl ester of |?-aminocrotonic acid with the 2-methyl-2-benzylaminoethyl ester of acetoacetic acid.

Nicardipine Preparation Products And Raw materials

Raw materials

3,5-Pyridinedicarboxylic acid Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-Nitrobenzaldehyde Chloroethyl acetoacetate trans-Methyl crotonate

Preparation Products

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View Lastest Price from Nicardipine manufacturers

Hebei Duling International Trade Co. LTD

Product: Nicardipine 55985-32-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2022-10-18

Dideu Industries Group Limited

Product: Nicardipine 55985-32-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-06

Shaanxi Dideu Medichem Co. Ltd

Product: Nicardipine 55985-32-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

55985-32-5, NicardipineRelated Search:

Benzyl alcohol N,N-Dimethylformamide Dimethyl sulfoxide ETHANE Dimethyl carbonate Poly(dimethylsiloxane) Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Dimethyl fumarate Dimethyl ether Chlorodimethylphenylsilane Dimethyl sulfate 1-(2,6-Dimethylphenoxy)-2-propanamine NICARDIPINE HYDROCHLORIDE,NICARDIPINE HCL,NICARDIPINE HYDROCHLORIDE (YC-93) CALCIU M CHANNEL ANTAG,NICARDIPINE HYDROCHLORIDE MM(CRM STANDARD) Barnidipine Benidipine Barnidipine hydrochloride Benzyl Nicardipine-D3

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methy(phenyl-methyl)amino]ethyl ester hydrochloride

Nicardipine (base and/or unspecified salts)

Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[methyl(benzyl)amino]ethyl]5-methyl ester

NicardipineBase

Nicardipine Hcl 54527-84-3 / Base

2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate

benzylmethylamino)ethylmethylester

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[methyl(benzyl)amino]ethyl] ester

2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-(N-methylbenzylamino)ethyl] ester

2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-[2-[benzyl(methyl)amino]ethyl] ester O5-methyl ester

5-O-methyl 3-O-[2-[methyl(phenylmethyl)amino]ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

O5-methyl O3-[2-[methyl(phenylmethyl)amino]ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

NICARDIPINE

5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-[2-[methyl(phenylmethyl)amino]ethyl] ester

Nicardipine USP/EP/BP

NICARDIPINE 20% SR, 33% SR PELLETS

55985-32-5

C26H29N3O6

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