Synthesis
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4-Fluoroanisole

Synthesis
Product Name
4-Fluoroanisole
CAS No.
459-60-9
Chemical Name
4-Fluoroanisole
Synonyms
1-FLUORO-4-METHOXYBENZENE;NSC 4672;4-Fluoranisol;p-fluoroanisol;4-FLUOROANISOL;4-fluoranisole;4-Floroanisole;P-FLUOROANISOLE;4-FLUOROANISOLE;Anisole, p-fluoro-
CBNumber
CB2494904
Molecular Formula
C7H7FO
Formula Weight
126.13
MOL File
459-60-9.mol
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4-Fluoroanisole Property

Melting point:
−45 °C(lit.)
Boiling point:
157 °C(lit.)
Density 
1.114 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.488(lit.)
Flash point:
110 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Liquid
Specific Gravity
1.114
color 
Clear colorless to light yellow
Water Solubility 
Not miscible or difficult to mix in water.
BRN 
1281425
InChIKey
VIPWUFMFHBIKQI-UHFFFAOYSA-N
CAS DataBase Reference
459-60-9(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-fluoro-4-methoxy-(459-60-9)
EPA Substance Registry System
p-Fluoroanisole (459-60-9)
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Safety

Hazard Codes 
F
Risk Statements 
10
Safety Statements 
16
RIDADR 
UN 3271 3/PG 3
WGK Germany 
3
Hazard Note 
Flammable
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F4602
Product name
4-Fluoroanisole
Purity
99%
Packaging
25g
Price
$50.3
Updated
2024/03/01
TCI Chemical
Product number
F0231
Product name
4-Fluoroanisole
Purity
>97.0%(GC)
Packaging
25g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
F0231
Product name
4-Fluoroanisole
Purity
>97.0%(GC)
Packaging
500g
Price
$236
Updated
2024/03/01
Alfa Aesar
Product number
B23048
Product name
4-Fluoroanisole, 99%
Packaging
100g
Price
$99.65
Updated
2024/03/01
Usbiological
Product number
012170
Product name
4-Fluoroanisole
Packaging
1g
Price
$312
Updated
2021/12/16
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4-Fluoroanisole Chemical Properties,Usage,Production

Synthesis

Fluorine itself reacts with a 4-substituted methoxy benzene tin derivative to give 4-fluoroanisole.

Chemical Properties

Colorless to light yellow liquid

Uses

An Acetanilide and Anisole derivative metabolite by liver.

Uses

4-Fluoroanisole is a raw material for medicine and intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 1886, 1986 DOI: 10.1021/jo00360a042

4-Fluoroanisole Preparation Products And Raw materials

Raw materials

Preparation Products

5-Fluoro-2-methoxyphenylboronic acid 2-FLUORO-5-HYDROXYBENZOIC ACID 2-FLUORO-5-METHOXYBENZOIC ACID
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4-Fluoroanisole Suppliers

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View Lastest Price from 4-Fluoroanisole manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
4-Fluoroanisole 459-60-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-21
Henan Fengda Chemical Co., Ltd
Product
4-Fluorobenzyl alcohol 459-60-9
Price
US $9.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Fluoroanisole 459-60-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

459-60-9, 4-FluoroanisoleRelated Search:

1,2-Difluorobenzene 4-Fluorobenzoic acid Anisole 4-Bromofluorobenzene 4-Fluorobenzaldehyde Florfenicol Transfluthrin 4-Fluorobenzyl alcohol 4-Fluoroacetophenone 4-Fluorophenylacetic acid 4-Fluorophenylacetyl chloride Fluorine 3-Fluoroanisole 99% 3,5-Difluoroanisole 3-BROMO-2-FLUOROANISOLE 2-BROMO-4-CHLORO-6-FLUOROANISOLE 2,3-Difluoroanisole 4-AMINO-2,6-FLUOROANISOLE

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  • 4-Fluoroanisole (CAS No 459-60-9)
  • 4-Fluoroanisole&gt
  • 4-Fluoroanisole ISO 9001：2015 REACH
  • 4-Fluoroanisole extrapure, 99%
  • 459-60-9
  • 459-56-1
  • 459-60-6
  • Building Blocks
  • Oxygen Compounds
  • Organic Building Blocks
  • Ethers
  • Aromatics, Metabolites & Impurities
  • Aromatics
  • Metabolites & Impurities
  • Fluorinated benzene series
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • C2 to C7
  • C7-C8
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Other Fluorinated Organic Building Blocks
  • Oxygen Compounds
  • Benzene series
  • AnisoleSeries
  • Fluorobenzene
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Fluorine Compounds