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DAPH

Product Name
DAPH
CAS No.
145915-58-8
Chemical Name
DAPH
Synonyms
DAPH-1 (DAPH;DAPH/CGP 52411;CGP52411, 10 mM in DMSO;DAPH >=98% (HPLC), solid;1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-;4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411
CBNumber
CB2498023
Molecular Formula
C20H15N3O2
Formula Weight
329.35
MOL File
145915-58-8.mol
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DAPH Property

Melting point:
199-202℃
Density 
1.374
storage temp. 
2-8°C
solubility 
DMSO: ~30 mg/mL
form 
solid
pka
9.06±0.20(Predicted)
color 
orange
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Safety

Safety Statements 
36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

Precautionary statements

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D3943
Product name
DAPH
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$142.8
Updated
2025/07/31
Sigma-Aldrich
Product number
D3943
Product name
DAPH
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$616
Updated
2025/07/31
Cayman Chemical
Product number
29196
Product name
DAPH
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
29196
Product name
DAPH
Packaging
25mg
Price
$651
Updated
2024/03/01
Cayman Chemical
Product number
29196
Product name
DAPH
Packaging
5mg
Price
$156
Updated
2024/03/01
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DAPH Chemical Properties,Usage,Production

Uses

CGP 52411 is a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitmuor activity. It may offer therapeutic agents for the treatment of hyperproliferative diseases.

Definition

ChEBI: 4,5-dianilinophthalimide is phthalimide substituted at the 4- and 5-positions by anilino groups. It has a role as a tyrosine kinase inhibitor and a geroprotector.

Biochem/physiol Actions

DAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR.

in vivo

CGP52411 (3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg; oral administration; daily; for 15 days; female BALB/c nude mice) treatment in vivo against xenografts of the A431 and SK-OV-3 tumors, and has antitumor activity[1].

Animal Model:Female BALB/c nude mice injected with A431cells[1]
Dosage:3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg
Administration:Oral administration; daily; for 15 days
Result:Antitumor efficacy was obtained at doses between 50 mg/kg and 6.3 mg/kg.

IC 50

EGFR: 0.3 μM (IC50); Amyloid-β

DAPH Preparation Products And Raw materials

Raw materials

Preparation Products

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DAPH Suppliers

China 29 Switzerland 1 United Kingdom 2 United States 9 Global 41
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
Glentham Life Sciences
Tel
--
Fax
--
Email
info@glenthamls.com
Country
United Kingdom
ProdList
1429
Advantage
0

145915-58-8, DAPHRelated Search:

TYRPHOSTIN B48 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE PD168393 TYRPHOSTIN A51 AG 213 CIVENTICHEM CV-409 AG 1478 HYDROCHLORIDE AG 18 LAVENDUSTIN A METHYL 2,5-DIHYDROXYCINNAMATE H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH AG 825 TYRPHOSTIN A25 Canertinib

  • DAPH-1 (DAPH
  • DAPH/CGP 52411
  • 4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411
  • 1H-Isoindole-1,3(2H)-dione, 5,6-bis(phenylamino)-
  • DAPH >=98% (HPLC), solid
  • CGP52411, 10 mM in DMSO
  • 145915-58-8