Hypericum perforatum extracts Indications Uses
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Hypericin

Hypericum perforatum extracts Indications Uses
Product Name
Hypericin
CAS No.
548-04-9
Chemical Name
Hypericin
Synonyms
Hypericins;Hyperici;Hypericine;VIMRxyn;CYCLOSAN;ypericin;HYPERICIN;MYCOPOPHYRIN;CYCLO-WERROL;HYPERICIN(P)
CBNumber
CB2696784
Molecular Formula
C30H16O8
Formula Weight
504.44
MOL File
548-04-9.mol
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Hypericin Property

Melting point:
299-301°C
Boiling point:
1020.3±65.0 °C(Predicted)
Density 
1.915±0.06 g/cm3(Predicted)
RTECS 
SF8472000
storage temp. 
-20°C
solubility 
1 M NaOH: 10 mg/mL
form 
powder
pka
6.91±0.20(Predicted)
color 
black
Water Solubility 
Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water.
Sensitive 
Light Sensitive
Merck 
14,4863
BRN 
1917913
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey
BTXNYTINYBABQR-UHFFFAOYSA-N
LogP
10.827 (est)
CAS DataBase Reference
548-04-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-40-43
Safety Statements 
22-36-36/37
RIDADR 
2811
WGK Germany 
3
F 
8
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89226
Product name
Hypericin
Purity
phyproof? Reference Substance
Packaging
10mg
Price
$688
Updated
2024/03/01
Sigma-Aldrich
Product number
00190585
Product name
Hypericin
Purity
primary pharmaceutical reference standard
Packaging
10mg
Price
$922
Updated
2024/03/01
Alfa Aesar
Product number
H26425
Product name
Hypericin, 98%
Packaging
25mg
Price
$750
Updated
2024/03/01
Alfa Aesar
Product number
H26425
Product name
Hypericin, 98%
Packaging
100mg
Price
$1716
Updated
2024/03/01
Cayman Chemical
Product number
11334
Product name
Hypericin
Purity
≥95%
Packaging
500μg
Price
$27
Updated
2024/03/01
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Hypericin Chemical Properties,Usage,Production

Hypericum perforatum extracts

Hypericin is an extract of Hypericum perforatum L.In 1957. It is first isolated from the Garcinia species Hypericum perforatum by human beings. Hypericin belongs to the bianthrone compounds, and it is the most biologically active substances. Hypericin is a yellowish brown to brown mobile powder, with slightly bitter taste. It is soluble in water, and can emit a special fragrance. It can inhibit the central nervous and has a sedative effect. Adding it to health care products can enhance immunity. It is also used as antidepressant drugs in Europe (especially in Germany). Hypericin also has a strong anti-viral effect, which can directly act on swine fever, foot and mouth disease and other viruses. In addition, it also has a good effect on killing highly pathogenic avian influenza virus.
Hypericum perforatum is one of the world's best-selling herbs in recent years, mainly containing hyperoside, quercetin, chlorogenic acid, caffeic acid, imanin, hypericin and other ingredients.
Hypericin is a few thousandths of the whole Hypericum perforatum. There are certain requirements for its extraction and testing. Methanol extraction method is common used in the past. Due to the toxicity of methanol, now the method is   converted to use ethanol to obtain the active ingredient.

Indications

Hypericin is an anti-virus and pure Chinese medicine preparations. It is the first choice for the prevention and treatment of avian influenza drugs.
1, avian influenza, atypical Newcastle disease, infectious bronchitis, avian infectious laryngotracheitis , bursa of Fabricius, duck plague, duck viral hepatitis, egg drop syndrome and other viral diseases.
2, poultry fever caused by high fever, dyspnea, cough, head and face swelling, crown hair purple, lack of energy, decreased feed intake, egg drop, producing more abnormal eggs.
3, for classical swine fever, blue ear disease, parvovirus, viral enteritis, infectious gastroenteritis and immune dysfunction.
4, Hypericin has a strong anti-viral effect both in vivo and in vitro. It has a strong inhibitory effect on the early replication of HIV. Hypericin can lead to cancer cell programmed death, with anti-cancer effect. It has a enhanced immune function  for activating mononuclear phagocytic cells. In addition, it has a strong role in killing the highly pathogenic H5N1 and H9N2 subtype of avian influenza virus.

Uses

(1) Antidepressant, increase immunity.
(2) For the treatment of antidepressants, increase immunity.

Description

An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.

Chemical Properties

Powder

Uses

It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.

Definition

ChEBI: Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene.

General Description

Produced by HWI Analytik
Exact content can be found on the certificate

Biological Activity

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

Biochem/physiol Actions

Primary TargetPKC

storage

+4°C

Purification Methods

Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]

References

1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775

Hypericin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Hypericin manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Hypericin 548-04-9
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-24
Bonerge(Hunan) Lifescience Co., Ltd.
Product
St. John′s Wort Extract
Price
US $0.00/kg
Min. Order
25kg
Purity
pending
Supply Ability
50000kg/Year
Release date
2023-05-05
Hebei Kingfiner Technology Development Co.Ltd
Product
Hypericin 548-04-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2024-05-21

548-04-9, HypericinRelated Search:

Hyperoside Perylene Pseudohypericin Tris(2,4-pentanedionato)chroMiuM(III) SALCOMINE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE Ferric acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE N-BUTYLISOCYANIDE Aluminum acetylacetonate METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) COBALT(II) ACETYLACETONATE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

  • HYPERICUM RED
  • HYPERICIN
  • HYPERICIN (NATIVE)
  • CYCLOSAN
  • CYCLO-WERROL
  • 1,3,4,6,8,13-HEXAHYDROXY-10,11-DIMETHYLPHENANTHRO[1,10,9,8-OPQRA]PERYLENE-7,14-DIONE
  • 1,3,4,6,8,13-HEXAHYDROXY-10,11-DIMETHYLPHENANTHROL(1,10,9,8,OPQRA)PERYLENE-7,14-DIONE
  • MYCOPOPHYRIN
  • MYCOPORPHYRIN
  • ST JOHN'S WORT POWDER
  • ST JOHN'S WORT EXTRACT
  • 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone
  • hypericinfromhypericumperforatum
  • 1,3,4,6,8,13-Hexahydroxy-10,11-dimethyl-7,14-dihydrophenanthro[1,10,9,8-opqra]perylene-7,14-dione
  • HYPERICINRESEARCH GRADE
  • Cyclo-Werrol: Hypericum red
  • Hypericin / 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione / 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethylnaphthodianthrone
  • Hypericin 1,3,4,6,8,13-Hexahydroxy-10,11-di-methylphenanthro(1,10,9,8,opqra)perylene-7,14-dione
  • Hypericin, >=98%
  • Hypericin CAS NO.548-04-9
  • PubChem ID: 5281051
  • Hypericin - CAS 548-04-9 - Calbiochem
  • Hypericin 548-04-9
  • Hypericin Hypericum perforatum
  • Hypericine
  • Hypericins
  • VIMRxyn
  • Phenanthro1,10,9,8-opqraperylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-, stereoisomer
  • ST.JOHNSWORTEXTRACT,4:1,POWDER
  • HYPERICIN(P)
  • STJOHN'SWORTHYPERICIN
  • HYPERICIN HPLC
  • Hypericin, Cyclo-Werrol
  • HYPERICIN WITH HPLC
  • dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-
  • Phenanthro [1,10,9,8-opqra]perylene-7,14-
  • Cyclo werrol, Hypericum red, 4,5,7,4μ,5μ,7μ-Hexahydroxy-2,2μ-dimethylnaphthodianthrone
  • Hypericin USP/EP/BP
  • 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione P-conformer
  • Hypericin (SGX301)
  • Hyperici
  • St John S wort extract, hypericin
  • ypericin
  • Hypericin-RM
  • 548-04-9
  • C30H16O8
  • 50444
  • BioChemical
  • Biochemicals and Reagents
  • P to Q
  • Protein kinase C
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Nutraceuticals
  • Antitumour
  • Natural Plant Extract
  • Anthraquinones, Hydroquinones and Quinones