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2-AMINO-5-FLUOROPHENOL

Product Name
2-AMINO-5-FLUOROPHENOL
CAS No.
53981-24-1
Chemical Name
2-AMINO-5-FLUOROPHENOL
Synonyms
EOS-61433;2-AMINO-5-FLUOROPHEN;5-Fluoro-2-aMinophenol;2-AMINO-5-FLUOROPHENOL;2-azanyl-5-fluoro-phenol;4-Fluoro-2-hydroxyaniline;2-Amino-5-fluorophenol98%;Phenol, 2-amino-5-fluoro-;2- aMino-5-difluoro phenol;2-Amino-5-fluorophenol 98%
CBNumber
CB2716633
Molecular Formula
C6H6FNO
Formula Weight
127.12
MOL File
53981-24-1.mol
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2-AMINO-5-FLUOROPHENOL Property

Melting point:
38°C
Boiling point:
246.1±25.0 °C(Predicted)
Density 
1.347±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO, Methanol
pka
8.76±0.10(Predicted)
form 
Solid
color 
Dark Beige
Water Solubility 
Slightly soluble in water.
Sensitive 
Air Sensitive
InChI
InChI=1S/C6H6FNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2
InChIKey
IIDUNAVOCYMUFB-UHFFFAOYSA-N
SMILES
C1(O)=CC(F)=CC=C1N
CAS DataBase Reference
53981-24-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29089990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2300
Product name
2-Amino-5-fluorophenol
Purity
>97.0%(GC)
Packaging
1g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
A2300
Product name
2-Amino-5-fluorophenol
Purity
>97.0%(GC)
Packaging
5g
Price
$110
Updated
2025/07/31
TRC
Product number
A609600
Product name
2-Amino-5-fluorophenol
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
A609600
Product name
2-Amino-5-fluorophenol
Packaging
5g
Price
$50
Updated
2021/12/16
Usbiological
Product number
002246
Product name
2-Amino-5-fluorophenol
Packaging
1g
Price
$319
Updated
2021/12/16
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2-AMINO-5-FLUOROPHENOL Chemical Properties,Usage,Production

Chemical Properties

Dark Beige Solid

Uses

2-Amino-5-fluorophenol is a fluoroaniline metabolite. 2-Amino-5-fluorophenol is used as organic intermediate. To synthesize the intermediate (2-amino-5-fluorophenol-N, N, O-triacetic acid trimethyl ester) of indicator which used in the determination Mg2+ by NMR, three feasible reactions were experimentally carried out, such as alkaline hydrolysis, catalytic hydrogenation and esterification.

Synthesis

446-36-6

53981-24-1

The general procedure for the synthesis of 2-amino-5-fluorophenol from 5-fluoro-2-nitrophenol is as follows: 5-fluoro-2-nitrophenol (2.50 g, 15.9 mmol, commercially available from e.g., Aldrich) was dissolved in ethanol (50 ml), and 10% palladium-carbon catalyst (980 mg) was added for the hydrogenation reaction, which lasted for 1.5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The solid residue obtained was dissolved in ether, followed by addition of an equal volume of cyclohexane. The ether was removed by vacuum distillation at room temperature to give a light gray solid product. The product was filtered and washed with cyclohexane to give 2-amino-5-fluorophenol (1.90 g, 94% yield). Elemental analysis measured values: C, 56.4; H, 4.8; N, 10.9. theoretical values (C6H6FNO): C, 56.7; H, 4.8; N, 11.0%.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[2] Patent: WO2010/94643, 2010, A1. Location in patent: Page/Page column 46
[3] Patent: US5238908, 1993, A
[4] Patent: US5393735, 1995, A
[5] Chemistry - A European Journal, 2011, vol. 17, # 33, p. 9076 - 9082

2-AMINO-5-FLUOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-FLUOROPHENOL Suppliers

Americas 1 Belgium 1 Canada 3 China 191 Europe 3 France 2 Germany 7 India 6 Italy 1 Japan 1 The Netherlands 1 United Kingdom 18 United States 38 Global 273
Toronto Research Chemicals
Tel
--
Fax
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Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
Toronto Research Chemicals Inc.
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6668
Advantage
58
AB Chemicals Inc.
Tel
--
Fax
--
Email
sales@abcheminc.com
Country
Canada
ProdList
1128
Advantage
47
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View Lastest Price from 2-AMINO-5-FLUOROPHENOL manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-AMINO-5-FLUOROPHENOL 53981-24-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-11-22
Career Henan Chemical Co
Product
2-AMINO-5-FLUOROPHENOL 53981-24-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-27

53981-24-1, 2-AMINO-5-FLUOROPHENOLRelated Search:

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  • 2-AMINO-5-FLUOROPHENOL
  • 2-Amino-5-fluorophenol 98%
  • 2-Amino-5-fluorophenol98%
  • 2-Amino-5-fluorophenol 97+%
  • 2-azanyl-5-fluoro-phenol
  • 2-Amino-5-fluorophenol ,90%
  • 2-AMINO-5-FLUOROPHEN
  • 4-Fluoro-2-hydroxyaniline
  • (4-Fluoro-2-hydroxyphenyl)aMine
  • 5-Fluoro-2-aMinophenol
  • 2- aMino-5-difluoro phenol
  • EOS-61433
  • 2-Amino-5-fluorophenol &gt
  • Phenol, 2-amino-5-fluoro-
  • 2-AMINO-5-FLUOROPHENOL ISO 9001：2015 REACH
  • 53981-24-1 2-AMINO-5-FLUOROPHENOL
  • 2-Amino-5-Fluorophenol, 10 mM in DMSO
  • 53981-24-1
  • Aromatic Phenols
  • Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Phenol&Thiophenol&Mercaptan
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals