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2-Methoxythiophene

Product Name
2-Methoxythiophene
CAS No.
16839-97-7
Chemical Name
2-Methoxythiophene
Synonyms
Methoxythiophene;2-METHOXYTHIOPHENE;Thiophene, 2-methoxy-;2-Methoxythiophene>2-Methoxythiophene 97%;2-Methoxythiophene,99%;2-Methoxythiophene,97%;METHYL 2-THIENYL ETHER;2-Methoxythiophene ISO 9001：2015 REACH
CBNumber
CB2748272
Molecular Formula
C5H6OS
Formula Weight
114.17
MOL File
16839-97-7.mol
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2-Methoxythiophene Property

Boiling point:
151-152 °C/762 mmHg (lit.)
Density 
1.133 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.528(lit.)
Flash point:
110 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol (Slightly)
form 
clear liquid
color 
Colorless to Light yellow to Light orange
BRN 
106271
InChI
InChI=1S/C5H6OS/c1-6-5-3-2-4-7-5/h2-4H,1H3
InChIKey
OKEHURCMYKPVFW-UHFFFAOYSA-N
SMILES
C1(OC)SC=CC=1
LogP
2.130
CAS DataBase Reference
16839-97-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Methoxythiophene(16839-97-7)
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Safety

Risk Statements 
10
Safety Statements 
16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
HazardClass 
3
PackingGroup 
III
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
331597
Product name
2-Methoxythiophene
Purity
97%
Packaging
5g
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
M1030
Product name
2-Methoxythiophene
Purity
>98.0%(GC)
Packaging
5g
Price
$97
Updated
2025/07/31
TCI Chemical
Product number
M1030
Product name
2-Methoxythiophene
Purity
>98.0%(GC)
Packaging
25g
Price
$330
Updated
2025/07/31
TRC
Product number
M271690
Product name
2-Methoxythiophene
Packaging
10g
Price
$360
Updated
2021/12/16
TRC
Product number
M271690
Product name
2-Methoxythiophene
Packaging
1g
Price
$110
Updated
2021/12/16
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2-Methoxythiophene Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

2-Methoxythiophene was used in thermal reaction (60°C) of (C5Me5)Rh(PMe3)(Ph)H.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 3697, 1953 DOI: 10.1021/ja01111a027

General Description

2-Methoxythiophene is a heterocyclic methyl enol ether and its reaction with o-quinone monoimide was studied. The intramolecular and intermolecular geometries of crystals of 2-methoxythiophene were investigated. Kinetics of the hydronium-ion catalysed hydrolysis of 2-methoxythiophene was reported.

Synthesis

1003-09-4

124-41-4

16839-97-7

Example 1 Preparation of 2-methoxythiophene: In a reactor, 300 g of 2-bromothiophene (1.84 mol), 2.64 g of copper(I) bromide (CuBr, 1 mol%), 18.4 g of polyethylene glycol dimethyl ether (PEG DME 500, 2 mol%), and 660 g of a methanolic solution of sodium methanolate (30% concentration, precursor concentration of 30.6%) were added in sequence. The mixture was heated to 90 °C for the reaction and the progress of the reaction was monitored by gas chromatography (GC) until the conversion was >98% (total reaction time 8h). Upon completion of the reaction, the reaction mixture was slowly poured into 500 g of water and filtered through Decalite. Subsequently, the aqueous phase was extracted twice with methyl tert-butyl ether (MTBE, 150 g each time). The organic phases were combined and purified by vacuum fractional distillation to give a final 182 g of 2-methoxythiophene (1.59 mol, 86.4% yield) with a GC purity of >99% (% area).

References

[1] Patent: US2008/71084, 2008, A1. Location in patent: Page/Page column 3-4
[2] Synthetic Communications, 1990, vol. 20, # 2, p. 213 - 216
[3] Tetrahedron, 1992, vol. 48, # 17, p. 3633 - 3652
[4] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8651 - 8664

2-Methoxythiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxythiophene Suppliers

Americas 1 Austria 1 Belgium 2 Canada 1 China 157 Europe 1 France 2 Germany 8 India 7 Italy 1 Japan 3 Slovakia 2 Switzerland 3 The Netherlands 1 United Kingdom 13 United States 32 USA 1 Global 236
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
Chemodex Ltd.
Tel
--
Fax
--
Email
info@chemodex.com
Country
Switzerland
ProdList
1549
Advantage
50
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 2-Methoxythiophene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Methoxythiophene 16839-97-7
Price
US $9.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Henan Aochuang Chemical Co.,Ltd.
Product
2-Methoxythiophene 16839-97-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Henan Fengda Chemical Co., Ltd
Product
2-Methoxythiophene 16839-97-7
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30

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