2-Fluoro-6-methoxybenzonitrile

Product Name: 2-Fluoro-6-methoxybenzonitrile
CAS No.: 94088-46-7
Chemical Name: 2-Fluoro-6-methoxybenzonitrile
Synonyms: BUTTPARK 45\03-64;6-FLUORO-O-ANISONITRILE;2-CYANO-3-FLUOROANISOLE;uoro-6-methoxybenzonitriL;2-Fluoro-6-Methoxycyanobenzene;2-FLUORO-6-METHOXYBENZONITRILE;2-methoxy-6-fluorobenzonitrile;2-FLUORO-6-DIMETHOXYBENZONITRILE;Benzonitrile, 2-fluoro-6-Methoxy-;2-Fluoro-6-methoxybenzonitrile98%
CBNumber: CB2772057
Molecular Formula: C8H6FNO
Formula Weight: 151.14
MOL File: 94088-46-7.mol

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2-Fluoro-6-methoxybenzonitrile Property

Melting point:: 103-105 °C(lit.)
Boiling point:: 232.1±20.0 °C(Predicted)
Density: 1.18±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white
BRN: 4179192
InChI: InChI=1S/C8H6FNO/c1-11-8-4-2-3-7(9)6(8)5-10/h2-4H,1H3
InChIKey: YPMSIWYNTPSPMV-UHFFFAOYSA-N
SMILES: C(#N)C1=C(OC)C=CC=C1F
CAS DataBase Reference: 94088-46-7(CAS DataBase Reference)
NIST Chemistry Reference: Benzonitrile, 2-fluoro-6-methoxy-(94088-46-7)

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Safety

Hazard Codes: Xi,T,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-36
RIDADR: 3276
WGK Germany: 3
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 406058
Product name: 2-Fluoro-6-methoxybenzonitrile
Purity: 98%
Packaging: 10g
Price: $179
Updated: 2023/06/20

TCI Chemical

Product number: F0969
Product name: 2-Fluoro-6-methoxybenzonitrile
Purity: >98.0%(GC)
Packaging: 5g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: F0969
Product name: 2-Fluoro-6-methoxybenzonitrile
Purity: >98.0%(GC)
Packaging: 25g
Price: $169
Updated: 2025/07/31

TRC

Product number: F595803
Product name: 2-Fluoro-6-methoxybenzonitrile
Packaging: 10g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: PC3817F
Product name: 2-Fluoro-6-methoxybenzonitrile
Purity: 98%
Packaging: 100g
Price: $61
Updated: 2021/12/16

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2-Fluoro-6-methoxybenzonitrile Chemical Properties,Usage,Production

Chemical Properties

White crystals

General Description

2-Fluoro-6-methoxybenzonitrile (FMBN) is a fluorinated organic building block used in organic synthesis. Molecular structure and vibrational spectra of FMBN have been investigated.

Synthesis

1897-52-5

124-41-4

94088-46-7

Synthetic route 2.1.5: 2-fluoro-6-methoxybenzonitrile (similar to WO 99/14187): 640.5 g (4.6 mol) of 2,6-difluorobenzonitrile was dissolved in 3.5 L of methanol and subsequently cooled to 0-5 °C. In this temperature range, 828.8 g of 30% sodium methanol solution was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was poured into 20 L of water and the precipitate was collected by filtration. The precipitate was washed sequentially twice with water and twice with heptane. The resulting solid was dried under vacuum at 50 °C. A final 740 g of white solid product was obtained in 99% yield of the theoretical value. The product was analyzed by GC and 1H NMR (CDCl3 as solvent) and the purity of the product was >95%.1H NMR data were as follows: δ = 3.95 ppm (single peak, 3H, O-CH3), 6.85 ppm (multiple peaks, 2H, aromatic H), 7.5 ppm (quadruple peak, 1H, aromatic H).

References

[1] Patent: WO2006/56433, 2006, A2. Location in patent: Page/Page column 29
[2] Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1173 - 1177
[3] Patent: WO2007/93530, 2007, A1. Location in patent: Page/Page column 244
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3135 - 3143
[5] Patent: WO2017/221092, 2017, A1. Location in patent: Paragraph 00153

2-Fluoro-6-methoxybenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-6-methoxybenzonitrile Suppliers

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View Lastest Price from 2-Fluoro-6-methoxybenzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Fluoro-6-methoxybenzonitrile 94088-46-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-21

Career Henan Chemical Co

Product: 2-Fluoro-6-Methoxybenzonitrile 94088-46-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

94088-46-7, 2-Fluoro-6-methoxybenzonitrileRelated Search:

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