PROTAC ER Degrader-4

Product Name: PROTAC ER Degrader-4
CAS No.: 2361114-15-8
Chemical Name: PROTAC ER Degrader-4
Synonyms: PROTAC ER Degrader-4;(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl]phenoxy}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
CBNumber: CB28054603
Molecular Formula: C53H67F3N6O8S
Formula Weight: 1005.19
MOL File: Mol file

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PROTAC ER Degrader-4 Property

Boiling point:: 1038.9±65.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
pka: 13.54±0.46(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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PROTAC ER Degrader-4 Chemical Properties,Usage,Production

Biological Activity

PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1]. PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].

References

[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.

PROTAC ER Degrader-4 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC ER Degrader-4 Suppliers

China 4 United States 1 Global 5

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

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PROTAC ER Degrader-4

(2S,4R)-1-[(2S)-2-(2-{2-[2-(2-{3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1H,2H,3H,4H,9H-pyrido[3,4-b]indol-1-yl]phenoxy}ethoxy)ethoxy]ethoxy}acetamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

2361114-15-8