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L-Homoserine

Product Name
L-Homoserine
CAS No.
672-15-1
Chemical Name
L-Homoserine
Synonyms
HOMOSERINE;HSE;(S)-2-AMINO-4-HYDROXYBUTANOIC ACID;H-HOMOSER-OH;H-HSE-OH;H-HOSER-OH;H-HOMOSERINE;(2S)-2-Amino-4-hydroxybutanoic acid;RODH;SDR9C6
CBNumber
CB2854094
Molecular Formula
C4H9NO3
Formula Weight
119.12
MOL File
672-15-1.mol
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L-Homoserine Property

Melting point:
203 °C (dec.)(lit.)
alpha 
-8.5 º (c=2, H2O 22 ºC)
Boiling point:
222.38°C (rough estimate)
Density 
1.3126 (rough estimate)
refractive index 
1.4183 (estimate)
storage temp. 
Store below +30°C.
solubility 
1100g/l
pka
2.71(at 25℃)
form 
Crystalline Powder
color 
White to light yellow
Water Solubility 
1100 g/L (30 ºC)
Merck 
14,4739
BRN 
1721681
InChIKey
UKAUYVFTDYCKQA-VKHMYHEASA-N
LogP
-1.289 (est)
CAS DataBase Reference
672-15-1(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25-44-35-26-28-7-4-3/9
WGK Germany 
3
10
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6515
Product name
L-Homoserine
Packaging
1g
Price
$365
Updated
2024/03/01
Sigma-Aldrich
Product number
H6515
Product name
L-Homoserine
Packaging
5g
Price
$1720
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14359
Product name
L-(-)-Homoserine
Purity
for synthesis
Packaging
1g
Price
$147
Updated
2024/03/01
TCI Chemical
Product number
H1030
Product name
L-Homoserine
Purity
>98.0%(T)
Packaging
1g
Price
$62
Updated
2024/03/01
TCI Chemical
Product number
H1030
Product name
L-Homoserine
Purity
>98.0%(T)
Packaging
5g
Price
$204
Updated
2024/03/01
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L-Homoserine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystalline powder

Uses

L-Homoserine is used in the biosynthesis of methionine, threonine and isoleucine. It is also used as an internal standard for neurotransmitter analysis and amino acids quantification.

Definition

ChEBI: L-homoserine is the L-enantiomer of homoserine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite and an Escherichia coli metabolite. It is an enantiomer of a D-homoserine. It is a tautomer of a L-homoserine zwitterion.

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 3147, 1958 DOI: 10.1021/ja01545a057
The Journal of Organic Chemistry, 24, p. 1794, 1959 DOI: 10.1021/jo01093a610

General Description

L-Homoserine is a variant of serine with an additional carbon on its side chain.

Biochem/physiol Actions

L-Homoserine is synthesized by deoxidation process, catalysed by homoserine dehydrogenase. This is one of the steps in the synthesis of L-threonine. The carbon flux in in bacteria such as E. coli is maintained by this reaction.

Purification Methods

Likely impurities are N-chloroacetyl-L-homoserine, N-chloroacetyl-D-homoserine, L-homoserine, homoserine lactone, homoserine anhydride (formed in strong solutions of homoserine if slightly acidic). It cyclises to the lactone in strongly acidic solution. It crystallises from water by adding 9 volumes of EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2612-2616 1961, Beilstein 4 IV 3187.]

L-Homoserine Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Homoserine Suppliers

INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
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View Lastest Price from L-Homoserine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Homoserine 672-15-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
5000kg/month
Release date
2021-10-13
Honest Joy Holdings Limited
Product
L-Homoserine 672-15-1
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100 tons
Release date
2022-02-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
L-Homoserine 672-15-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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