ChemicalBook > CAS DataBase List > UCN-01

UCN-01

Product Name
UCN-01
CAS No.
112953-11-4
Chemical Name
UCN-01
Synonyms
UNC 01;UCN-01;KW-2401;KRX-0601;NSC 638850;UCN01,UCN 01;KRX-0601，UCN-01;7-hydroxystaurosporine;7-alfa-Hydroxystaurosporine (UCN-01);(5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa
CBNumber
CB2972499
Molecular Formula
C28H26N4O4
Formula Weight
482.53044
MOL File
112953-11-4.mol
More
Less

UCN-01 Property

Boiling point:
705.7±60.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >5mg/mL
form 
Tan solid
pka
12.25±0.70(Predicted)
color 
light yellow
optical activity
[α]20/D 130 to 160°, c = 0.2 in DMSO
InChIKey
PBCZSGKMGDDXIJ-HQCWYSJUSA-N
SMILES
[n]21c3c4[n](c6c(c4c7c(c3c8c2cccc8)[C@H](NC7=O)O)cccc6)[C@@H]5O[C@]1([C@@H]([C@@H](C5)NC)OC)C
More
Less

Safety

WGK Germany 
3
RTECS 
KC6600010
Storage Class
11 - Combustible Solids
Toxicity
mouse,LD50,intraperitoneal,25mg/kg (25mg/kg),Journal of Antibiotics. Vol. 42, Pg. 571, 1989.
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U6508
Product name
UCN-01
Purity
≥97% (HPLC), powder
Packaging
1mg
Price
$251
Updated
2026/03/19
Sigma-Aldrich
Product number
539644
Product name
UCN-01
Purity
A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.
Packaging
500μg
Price
$270
Updated
2026/03/19
Cayman Chemical
Product number
18130
Product name
UCN-01
Purity
≥95%
Packaging
1mg
Price
$179
Updated
2024/03/01
Sigma-Aldrich
Product number
U6508
Product name
UCN-01
Purity
≥97% (HPLC), powder
Packaging
5mg
Price
$986
Updated
2026/03/19
ApexBio Technology
Product number
C4783
Product name
UCN-01
Packaging
1mg(solution)
Price
$215
Updated
2021/12/16
More
Less

UCN-01 Chemical Properties,Usage,Production

Description

UCN-01 is a synthetic derivative of staurosporine with antiproliferative activity against several in vitro and in vivo cancer models. It inhibits a variety of kinases, including Akt, protein kinase C (IC50 = 30 nM), PDK1 (IC50 = 6 nM) and cyclin-dependent kinases (IC50s = 300-600 nM for Cdk1 and Cdk2). UCN-01 arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase Chk1 (IC50 = 7 nM), leading to apoptosis.

Uses

UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.

Uses

UCN 01 is a protein kinase C inhibitor which overrides ZEB1-induced chemoresistance in hepatocellular cancer in human. A cell-permeable Staurosporine derived anticancer agent that inhibits several protein kinases.

General Description

A cell-permeable Staurosporine (Cat. No. 569397) derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases (IC50 = 29 nM, 34 nM, 30 nM, 590 nM and 530 nM for PKCα, PKCβ, PKCγ, PKCδ and PKCε; IC50 = 7 nM, 27 nM, 50 nM, 50 nM, 150 nM and 1.04 M for Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2; IC50 = 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 M for PDK1, lck, MAPKAP kinase-2, Akt, GSK-3β and PKA, respectively). At higher concentrations (>15 M), affects the activities of Src, PIM-1, CKII, DNA-PK, ErK1, ILK-1 and MAPKK1). Reported to suppress thymidylate synthase expression, induce apoptosis with caspase activation, and sensitize tumor cells to a range of DNA-damaging agents.

Biochem/physiol Actions

Cell permeable: yes

References

[1] KAWABE T. G2 checkpoint abrogators as anticancer drugs.[J]. Molecular Cancer Therapeutics, 2004, 3 4 1: 513-519. DOI: 10.1158/1535-7163.513.3.4
[2] CHRISTIAN PEIFER DR.  DarioR. A ProfDr. Small-Molecule Inhibitors of PDK1[J]. ChemMedChem, 2008, 3 12: 1810-1838. DOI: 10.1002/cmdc.200800195
[3] A M SENDEROWICZ  E A S. Preclinical and clinical development of cyclin-dependent kinase modulators.[J]. JNCI Journal of the National Cancer Institute, 2000, 92 5: 376-387. DOI: 10.1093/jnci/92.5.376
[4] Q WANG. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.[J]. JNCI Journal of the National Cancer Institute, 1996, 88 14: 956-965. DOI: 10.1093/jnci/88.14.956
[5] TAKAHIRO YAMAUCHI  William P  Michael J Keating. UCN-01 (7-hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes.[J]. Molecular Cancer Therapeutics, 2002, 1 4: 287-294.
[6] MARIA M FACCHINETTI. UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway.[J]. Cancer research, 2004, 64 10: 3629-3637. DOI: 10.1158/0008-5472.can-03-3741

UCN-01 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

UCN-01 Suppliers

China 58 Switzerland 1 United Kingdom 1 United States 7 Global 67
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16055
Advantage
64
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
26658
Advantage
65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 17714375163
Email
yftan@aikonchem.com
Country
China
ProdList
16676
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1377
Advantage
58

112953-11-4, UCN-01Related Search:

TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Ferric acetylacetonate METHYL ISOCYANOACETATE SALCOMINE COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE Aluminum acetylacetonate 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) PHENYLSELENOL Benzyl isocyanide Tosylmethyl isocyanide Ethyl isocyanoacetate Cupric acetylacetonate TERT-BUTYL ISOCYANIDE

  • UCN-01
  • 7-hydroxystaurosporine
  • KW-2401
  • (9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-Methoxy-9-Methyl-11-(MethylaMino)-, (3R,9S,10R,11R,13R)-
  • KRX-0601
  • NSC 638850
  • UNC 01
  • (5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa
  • (5S,6R,7R,9R,16R)-16-Hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one
  • KRX-0601，UCN-01
  • UCN01,UCN 01
  • (3R,9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo1,2,3-gh:3',2',1'-lMpyrrolo3,4-j1,7benzodiazonin-1-one
  • 7-alfa-Hydroxystaurosporine (UCN-01)
  • 112953-11-4