Ethyl 4-pyrimidinecarboxylate
- Product Name
- Ethyl 4-pyrimidinecarboxylate
- CAS No.
- 62846-82-6
- Chemical Name
- Ethyl 4-pyrimidinecarboxylate
- Synonyms
- Ethyl 4-pyrimidinecarboxylate;ethylpyrimidine-4-carboxylate;EthylPyrimidine-4-carboxylate>PyriMidine-4-carboxylic acid ethyl ester;4-PyriMidinecarboxylic acid, ethyl ester;PyriMidine-4-carboxylic acid ethyl ester 98%;4-Pyrimidinecarboxylicacid,ethylester(6CI,9CI);Ethyl 4-pyrimidinecarboxylate ISO 9001：2015 REACH;ethyl pyriMidine-4-carboxylate SynonyMs 4-PyriMidinecarboxylic
- CBNumber
- CB31011248
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 62846-82-6.mol
Ethyl 4-pyrimidinecarboxylate Property
- Melting point:
- 37.0 to 41.0 °C
- Boiling point:
- 240 ºC
- Density
- 1.167
- Flash point:
- 99 ºC
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to lump
- pka
- -0.76±0.10(Predicted)
- color
- White to Orange to Green
- CAS DataBase Reference
- 62846-82-6(CAS DataBase Reference)
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E0881
- Product name
- Ethyl Pyrimidine-4-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $106
- Updated
- 2026/04/30
- Product number
- E0881
- Product name
- Ethyl Pyrimidine-4-carboxylate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $321
- Updated
- 2026/04/30
- Product number
- 60710
- Product name
- ETHYL 4-PYRIMIDINECARBOXYLATE
- Purity
- 97%
- Packaging
- 1G
- Price
- $48
- Updated
- 2026/04/30
- Product number
- 60710
- Product name
- ETHYL 4-PYRIMIDINECARBOXYLATE
- Purity
- 97%
- Packaging
- 5G
- Price
- $140
- Updated
- 2026/04/30
- Product number
- 60710
- Product name
- ETHYL 4-PYRIMIDINECARBOXYLATE
- Purity
- 97%
- Packaging
- 25G
- Price
- $522
- Updated
- 2026/04/30
Ethyl 4-pyrimidinecarboxylate Chemical Properties,Usage,Production
Synthesis
31462-59-6
64-17-5
62846-82-6
General procedure for the synthesis of ethyl 4-pyrimidinecarboxylate from pyrimidine-4-carboxylic acid and ethanol: Thionyl chloride (3.55 mL, 48.4 mmol, 3 eq.) was slowly added dropwise to a solution of pyrimidine-4-carboxylic acid (2 g, 16.1 mmol) in anhydrous ethanol (15 mL). The reaction mixture was heated to reflux for 14 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted with saturated aqueous sodium bicarbonate solution to 8. Subsequently, the reaction mixture was extracted with ethyl acetate (4 x 50 mL). The organic phases were combined, washed with brine (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give Intermediate 23 (1.7 g, 77% yield). The product was confirmed by 1H NMR (DMSO-d6): δ 9.40 (d, J = 1.0 Hz, 1H), 9.10 (d, J = 5.1 Hz, 1H), 8.05 (dd, J = 5.1, 1.3 Hz, 1H), 4.39 (q, J = 7.1 Hz, 2H), 1.35 (t, J = 7.1 Hz, 3H); mass spectrum (MS): m/ z 153 [M + H]+; thin layer chromatography (TLC) conditions: 40% hexane/ethyl acetate, Rf = 0.40.
References
[1] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2676 - 2699
[2] Patent: WO2011/126903, 2011, A2. Location in patent: Page/Page column 92
[3] Patent: WO2014/145986, 2014, A1. Location in patent: Paragraph 0242; 0243
[4] Patent: US2017/326125, 2017, A1. Location in patent: Paragraph 0359-0361
[5] Bulletin des Societes Chimiques Belges, 1957, vol. 66, p. 276,289
Ethyl 4-pyrimidinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 4-pyrimidinecarboxylate manufacturers
- Product
- Ethyl 4-pyrimidinecarboxylate 62846-82-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-25