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1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER

Product Name
1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
CAS No.
144978-35-8
Chemical Name
1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
Synonyms
1-(tert-butyl) 2-ethyl (R)-5-oxopyrrolidine-1,2-dicarboxylate;(R)-1-Tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate;Boc-D-Pyrog;Boc-D-PyrogL;BOC-D-Pyr.Oet;Boc-D-ethyl pyroglutamate;Ethyl Boc-D-Pyroglutamate;Ethyl N-Boc-D-pyroglutamate;N-Boc-D-pyroglutamic Acid Ethyl;BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
CBNumber
CB31118695
Molecular Formula
C12H19NO5
Formula Weight
257.28
MOL File
144978-35-8.mol
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1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Property

Melting point:
54.0 to 58.0 °C
Boiling point:
375.0±35.0 °C(Predicted)
Density 
1.182±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
-4.15±0.40(Predicted)
color 
White to Almost white
optical activity
Consistent with structure
InChI
InChI=1S/C12H19NO5/c1-5-17-10(15)8-6-7-9(14)13(8)11(16)18-12(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
InChIKey
YWWWGFSJHCFVOW-MRVPVSSYSA-N
SMILES
N1(C(OC(C)(C)C)=O)C(=O)CC[C@@H]1C(OCC)=O
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Safety

HS Code 
2933.79.8500
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E0940
Product name
Ethyl N-(tert-Butoxycarbonyl)-D-pyroglutamate
Purity
>95.0%(GC)
Packaging
1g
Price
$66
Updated
2025/07/31
TCI Chemical
Product number
E0940
Product name
Ethyl N-(tert-Butoxycarbonyl)-D-pyroglutamate
Purity
>95.0%(GC)
Packaging
5g
Price
$200
Updated
2025/07/31
TRC
Product number
B658995
Product name
1-Boc-D-PyroglutamicAcidEthylEster
Packaging
1g
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0001331
Product name
1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
Purity
95.00%
Packaging
1G
Price
$154.35
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB41905
Product name
1-Boc-D-Pyroglutamic acid ethyl ester
Packaging
10g
Price
$180
Updated
2021/12/16
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1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Uses

1-Boc-D-Pyroglutamic acid ethyl ester is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research. It could synthesise (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid.

Synthesis

24424-99-5

7149-65-7

144978-35-8

An acetonitrile (150 mL) solution of di-tert-butyl dicarbonate (30.5 g, 0.14 mol) was slowly added to a reaction vial containing ethyl (S)-5-oxopyrrolidine-2-carboxylate (20 g, 0.127 mol) and di-tert-butyl dicarbonate (30.5 g, 0.14 mol) at 0 °C. 0.013 mol) in a reaction vial. The reaction mixture was stirred overnight at room temperature and then concentrated under vacuum. The residue was purified by fast chromatography (eluent: 30% ethyl acetate/hexane) to afford ethyl Boc-D-pyroglutamate (163A, 32.5 g, 100%) as an oil.1H NMR (CDCl3, 400 MHz) δ 4.58 (1H, dd, J = 3.0,9.5Hz), 4.22 (2H, q, J = 7.3Hz), 4.22 (2H, q, J = 7.3Hz), 4.22 (2H, q, J = 7.3Hz), 2.56-2.66 (2H, q, J = 7.3Hz). 2.56-2.66 (1H, m), 2.48 (1H, ddd, J = 3.8,9.6,13.1Hz), 2.25-2.35 (1H, m), 1.97-2.04 (1H, m), 1.48 (9H, s) and 1.28 (3H, t, J = 7.3Hz).

References

[1] Patent: US2008/9497, 2008, A1. Location in patent: Page/Page column 70-71
[2] Patent: EP2272825, 2015, B1. Location in patent: Paragraph 0138; 0139
[3] Organic Preparations and Procedures International, 2001, vol. 33, # 4, p. 405 - 409
[4] Organic and Biomolecular Chemistry, 2006, vol. 4, # 21, p. 3894 - 3897
[5] Patent: US2011/34438, 2011, A1. Location in patent: Page/Page column 25-26

1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Suppliers

Americas 1 China 204 Europe 1 India 6 Japan 1 United Kingdom 1 United States 12 Global 226
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
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View Lastest Price from 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER manufacturers

Changsha YuTeng New Materials Co., Ltd.
Product
1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER 144978-35-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
50kg/M
Release date
2025-03-03
Dingwang Technology (Wuhan) Co., Ltd.
Product
1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER 144978-35-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99% min
Supply Ability
20 tons
Release date
2024-08-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER 144978-35-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

144978-35-8, 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER Related Search:

Boc-D-Valine (R)-N-(tert-Butoxycarbonyl)-2-phenylglycinol N-Boc-D-Phenylalaninol Boc-D-prolinol BOC-D-4-Nitrophe BOC-D-PRO-OSU BOC-D-PHE-OSU Boc-D-Phenylglycine BOC-D-ORN(Z)-OH BOC-D-Phenylalanine L(-)-Pipecolinic acid Methyl N-(tert-butoxycarbonyl)-L-threoninate Boc-Hyp-OH Boc-L-serine methyl ester BOC-GUANIDINE Ethyl D-(-)-pyroglutamate BOC-D-PRO-OME 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER

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  • Ethyl N-(tert-Butoxycarbonyl)-D-pyroglutaMate
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  • BOC-D-Pyr.Oet
  • N-Boc-D-pyroglutamic acid ethyl ester
  • Ethyl <i>N</i>-(<i>tert</i>-Butoxycarbonyl)-<small>D</small>-pyroglutamate
  • 1-(tert-butyl) 2-ethyl (R)-5-oxopyrrolidine-1,2-dicarboxylate
  • (R)-5-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester
  • (R)-1-Tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate
  • BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
  • 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER
  • Ethyl Boc-D-Pyroglutamate
  • EthylN-(tert-Butoxycarbonyl)-D-pyroglutamate&gt
  • Boc-D-Pyrog
  • Boc-D-PyrogL
  • (R)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic Acid Ethyl Ester
  • Ethyl (R)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate
  • Ethyl N-Boc-D-pyroglutamate
  • N-(tert-Butoxycarbonyl)-D-pyroglutamic Acid Ethyl Ester
  • N-Boc-D-pyroglutamic Acid Ethyl
  • 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER USP/EP/BP
  • 1-O-tert-butyl 2-O-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate
  • 1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate
  • 1-BOC-D-PYROGLUTAMIC ACID ETHYL ESTER 144978-35-8
  • O1-tert-butyl O2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate
  • 1-Boc-D-pyroglutamic acid ethyl ester,95%
  • Boc-D-ethyl pyroglutamate
  • 144978-35-8
  • Amino Acids and Derivatives