ChemicalBook > CAS DataBase List > O-Desmorpholinopropyl Gefitinib

O-Desmorpholinopropyl Gefitinib

Product Name
O-Desmorpholinopropyl Gefitinib
CAS No.
184475-71-6
Chemical Name
O-Desmorpholinopropyl Gefitinib
Synonyms
4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-ol;FAAH-IN-2;Des-Gefitinib;N-(3-Chloro-4-f;FAAH inhibitor 2;Gefitinib iMpurity C;Gefitinib Intermediate 1;FAAH-IN-2, 10 mM in DMSO;Gefitinib interMediate VII;FAAH-IN-2 (Gefitinib Impurity)
CBNumber
CB31176644
Molecular Formula
C15H11ClFN3O2
Formula Weight
319.72
MOL File
184475-71-6.mol
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O-Desmorpholinopropyl Gefitinib Property

Melting point:
>260°C (dec.)
Boiling point:
478.8±45.0 °C(Predicted)
Density 
1.489±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Very Slightly, Heated)
form 
Solid
pka
8.18±0.40(Predicted)
color 
Pale Beige to Beige
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Safety

HS Code 
2933.59.8000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3647
Product name
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
Packaging
1G
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
C3647
Product name
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
Packaging
5G
Price
$218
Updated
2024/03/01
TRC
Product number
D296830
Product name
O-DesmorpholinopropylGefitinib
Packaging
5g
Price
$225
Updated
2021/12/16
Usbiological
Product number
008737
Product name
O-Desmorpholinopropyl Gefitinib
Packaging
100mg
Price
$418
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21367
Product name
O-Desmorpholinopropyl gefitinib
Packaging
5G
Price
$550
Updated
2021/12/16
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O-Desmorpholinopropyl Gefitinib Chemical Properties,Usage,Production

Description

O-Desmorpholinopropyl Gefitinib is a metabolite of Gefitinib, a potent inhibitor of tyrosine phosporylation in EGFR. The chemical structure of O-Desmorpholinopropyl Gefitinib consists of a quinazoline-6-ol core with a phenylamino group attached to a chloro-fluoro-phenyl ring, enabling it to interact with multiple biological targets. It is involved in inhibiting enzymes such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS).

Chemical Properties

Tan Solid

Uses

A metabolite of Gefitinib.

Definition

ChEBI: O-Desmorpholinopropyl Gefitinib is a member of quinazolines.

O-Desmorpholinopropyl Gefitinib Preparation Products And Raw materials

Raw materials

Preparation Products

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O-Desmorpholinopropyl Gefitinib Suppliers

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View Lastest Price from O-Desmorpholinopropyl Gefitinib manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-(3-chloro-4-fluorophenylami-no)-7-methoxyquinazolin-6-ol 184475-71-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%(HPLC)
Supply Ability
5000kg
Release date
2023-12-13
Henan Fengda Chemical Co., Ltd
Product
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 184475-71-6
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-27
Career Henan Chemical Co
Product
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 184475-71-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-26

184475-71-6, O-Desmorpholinopropyl GefitinibRelated Search:

Gefitinib Impurity 11 Gefitinib-d6 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate 4-(3-Chloropropyl)morpholine 3-Chloro-4-fluoroaniline 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate (Trifluoromethoxy)benzene Sulfaquinoxaline 4-Methoxyphenol Anisole Quinoxaline Gefitinib Chloro Impurity Gefitinib Impurity 8 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one Gefitinib 3,4-Difluoro Impurity HCl

  • FAAH-IN-2
  • 4-(3-Chloro-4-fluorophenylamino)-6-hydroxy-7-methoxyquinazoline
  • 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinol
  • O-Desmorpholinopropyl Gefitinib
  • 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
  • Gefitinib interMediate VII
  • 4-(3-Chlor-4-fluorophenylamino)-7-methoxyquinazolin-6-ol
  • Gefitinib Intermediate 1
  • 4-(3-Chloro-4-fluoroanilino)-6-hydroxy-7-methoxyquinazoline
  • N-(3-Chloro-4-f
  • FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib)
  • 6-Quinazolinol,4-[(3-chloro-4-fluorophenyl)aMino]-7-Methoxy-
  • Gefitinib iMpurity C
  • Gefitinib Impurity 12 (O-Desmorpholinopropyl Gefitinib)
  • FAAH inhibitor 2
  • Gefitinib O-Desmorpholinopropyl Impurity
  • 4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-ol
  • Des-Gefitinib
  • 4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-ol (O-Desmorpholinopropylgefitinib)
  • FAAH-IN-2 (Gefitinib Impurity)
  • 4- (3-Chloro-4-fluorophenylamino) -7-methoxyquinoline-6-alcohol
  • FAAH-IN-2, 10 mM in DMSO
  • 184475-71-6
  • C15H11ClFN3O2
  • Gefitinib
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals