ChemicalBook > CAS DataBase List > Gefitinib-d6

Gefitinib-d6

Product Name
Gefitinib-d6
CAS No.
1228664-49-0
Chemical Name
Gefitinib-d6
Synonyms
Gefitinib-d6;D6-Gefitinib;[2H6]-Gefitinib;Hexadeuterated gefitinib;N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
CBNumber
CB12674404
Molecular Formula
C22H24ClFN4O3
Formula Weight
446.91
MOL File
1228664-49-0.mol
More
Less

Gefitinib-d6 Property

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 0.3 mg/ml
form 
A solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22364
Product name
Gefitinib-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
500μg
Price
$130
Updated
2024/03/01
Cayman Chemical
Product number
22364
Product name
Gefitinib-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
1mg
Price
$243
Updated
2024/03/01
TRC
Product number
G304008
Product name
Gefitinib-d6
Packaging
10mg
Price
$1540
Updated
2021/12/16
TRC
Product number
G304008
Product name
Gefitinib-d6
Packaging
25mg
Price
$3520
Updated
2021/12/16
AK Scientific
Product number
3663DG
Product name
Gefitinib-d6
Packaging
1mg
Price
$370
Updated
2021/12/16
More
Less

Gefitinib-d6 Chemical Properties,Usage,Production

Description

Gefitinib-d6 is intended for use as an internal standard for the quantification of gefitinib by GC- or LC-MS. Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 μM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 μM). Gefitinib (0.1 to 1 μM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).

Uses

Gefitinib-d6 is the labeled version of Gefitinib (G304000), which is an antineoplastic.

References

[1] JOHN MENDELSOHN  Jose B. The EGF receptor family as targets for cancer therapy[J]. Oncogene, 2000, 19 56: 6550-6565. DOI: 10.1038/sj.onc.1204082
[2] F CIARDIELLO. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.[J]. Clinical Cancer Research, 2000, 6 5: 2053-2063.

Gefitinib-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Gefitinib-d6 Suppliers

China 14 United States 5 Global 19
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Shanghai YuZn Pharm. Technology Co.,Ltd.
Tel
15921286451; 15921286451
Email
2010681527@qq.com
Country
China
ProdList
5182
Advantage
58
Shanghai isotope chemical co.,ltd
Tel
021-51600108 13062666369
Email
sales@isotopechem.com
Country
China
ProdList
5000
Advantage
58
Shanghai Beiwanta Biotechnology Co., Ltd.
Tel
021-67187366 19901745723
Email
info@bwtlab.com
Country
China
ProdList
9650
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
17301488900
Fax
025-85560043
Email
judy.xia@synzest.com
Country
China
ProdList
12582
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29496
Advantage
58

1228664-49-0, Gefitinib-d6Related Search:

4-(3-Chloropropyl)morpholine 4,4'-(propane-1,3-diyl)bismorpholine Gefitinib N-Oxide 4-Defluoro-4-hydroxy Gefitinib Gefitinib 3-Hydroxy-4-methoxybenzonitrile 3-Chloro-4-fluoroaniline 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one 2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide 6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one 3,4-Dichloroaniline N-(3-chloro-4-fluorophenyl)-7 -methoxy-6-(3-morpholinopropoxy)-N-(3-morpholinopropyl)quinazolin-4-amine Gefitinib 3,4-Difluoro Impurity HCl 6,7-Dimethoxy-3,4-dihydroquinazoline-4-one 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol 3-Deschloro-4-Desfluoro-4-Chloro-3-Fluorogefitinib 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-yl acetate

  • Gefitinib-d6
  • Hexadeuterated gefitinib
  • [2H6]-Gefitinib
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy-1,1,2,2,3,3-d6]-4-quinazolinamine
  • D6-Gefitinib
  • 1228664-49-0