ChemicalBook > CAS DataBase List > 3',4'-Difluoroacetophenone

3',4'-Difluoroacetophenone

Product Name
3',4'-Difluoroacetophenone
CAS No.
369-33-5
Chemical Name
3',4'-Difluoroacetophenone
Synonyms
4´3',4'-Difluoro;3',4'-Difluoroacetop;OTAVA-BB BB7020410077;3,4-DIFLUOROACETOPHENONE;3',4'-difluoroacetophenone;3,4-Difluoroacetophenone,98%;3',4'-Difluoroacetophenone99%;3',4'-Difluoroacetophenone>3',4'-Difluoroacetophenone 99%
CBNumber
CB3130786
Molecular Formula
C8H6F2O
Formula Weight
156.13
MOL File
369-33-5.mol
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3',4'-Difluoroacetophenone Property

Melting point:
19-20 °C(lit.)
Boiling point:
94-95 °C13 mm Hg(lit.)
Density 
1.246 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.4916(lit.)
Flash point:
167 °F
storage temp. 
Sealed in dry,Room Temperature
form 
powder to lump to clear liquid
color 
White or Colorless to Light yellow
Specific Gravity
1.246
Water Solubility 
INSOLUBLE
BRN 
2206856
InChIKey
VWJSSJFLXRMYNV-UHFFFAOYSA-N
CAS DataBase Reference
369-33-5(CAS DataBase Reference)
NIST Chemistry Reference
3',4'-Difluoroacetophenone(369-33-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
264288
Product name
3′,4′-Difluoroacetophenone
Purity
97%
Packaging
5g
Price
$40.46
Updated
2025/07/31
TCI Chemical
Product number
D1906
Product name
3',4'-Difluoroacetophenone
Purity
>97.0%(GC)
Packaging
5g
Price
$27
Updated
2025/07/31
TCI Chemical
Product number
D1906
Product name
3',4'-Difluoroacetophenone
Purity
>97.0%(GC)
Packaging
25g
Price
$77
Updated
2025/07/31
TRC
Product number
D445548
Product name
3'',4''-Difluoroacetophenone
Packaging
500mg
Price
$45
Updated
2021/12/16
TRC
Product number
D445548
Product name
3'',4''-Difluoroacetophenone
Packaging
5g
Price
$75
Updated
2021/12/16
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3',4'-Difluoroacetophenone Chemical Properties,Usage,Production

Chemical Properties

clear yellowish liquid after melting

Uses

3′,4′-Difluoroacetophenone may be used in chemical synthesis.

Definition

ChEBI: 1-(3,4-Difluorophenyl)ethan-1-one is an aromatic ketone.

Synthesis

367-11-3

75-36-5

369-33-5

Anhydrous aluminum trichloride (117 g) was slowly added to a mixed solution of 1,2-difluorobenzene (50 g) with acetyl chloride (86 g) at room temperature. The formed slurry was heated to 30°C with continuous stirring. Upon completion of the reaction, the red reaction mixture was cooled to 20 °C and subsequently slowly poured into 800 g of ice-water mixture with continued stirring for 30 min. The organic phase was separated and the aqueous phase was extracted with dichloromethane (3 x 500 ml). All organic phases were combined and washed sequentially with water (2 x 500 ml), saturated sodium bicarbonate solution (2 x 500 ml) and 15% brine (2 x 500 ml), followed by drying with anhydrous sodium sulfate. The organic phases were concentrated to remove the solvent and finally distilled under reduced pressure to collect the fractions at 95 °C/13 mmHg to give 3',4'-difluoroacetophenone (51 g).

References

[1] Journal of Fluorine Chemistry, 1980, vol. 15, p. 245 - 252
[2] Journal of the Indian Chemical Society, 1982, vol. 59, # 2, p. 293 - 294
[3] Heterocycles, 1981, vol. 16, # 9, p. 1545 - 1553
[4] Journal of Medicinal Chemistry, 1979, vol. 22, # 11, p. 1385 - 1389
[5] Heterocycles, 1981, vol. 16, # 1, p. 71 - 76

3',4'-Difluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3',4'-Difluoroacetophenone Suppliers

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View Lastest Price from 3',4'-Difluoroacetophenone manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
3′, 4′-Difluoroacetophenone 369-33-5
Price
US $9.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
100ton
Release date
2024-08-27
Honest Joy Holdings Limited
Product
3',4'-Difluoroacetophenone 369-33-5
Price
US $0.00/KG
Min. Order
1KG
Purity
97.6%
Supply Ability
100 tons
Release date
2022-02-18
Career Henan Chemical Co
Product
3',4'-Difluoroacetophenone 369-33-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
KG/T
Release date
2019-12-17

369-33-5, 3',4'-Difluoroacetophenone Related Search:

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  • 3′,4′-Difluoroacetophenone, CAS 369-33-5
  • 369-33-5
  • 69-33-5
  • KETONE
  • Organic Building Blocks
  • Ketones
  • C7 to C8
  • Carbonyl Compounds
  • Building Blocks
  • Acetophenone Series
  • Aromatic Acetophenones & Derivatives (substituted)
  • ketone
  • Miscellaneous
  • Adehydes, Acetals & Ketones
  • Fluorine Compounds
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • bc0001