(R)-2-Amino-3-methoxylpropanoic acid
Uses- Product Name
- (R)-2-Amino-3-methoxylpropanoic acid
- CAS No.
- 86118-11-8
- Chemical Name
- (R)-2-Amino-3-methoxylpropanoic acid
- Synonyms
- D-Ser(me);H-D-Ser(Me)-OH;H-D-OMe-Ser-OH;D-O-Methylserine;O-methyl-d-ser hcl;D-Serine, O-methyl-;O-Methyl-D-Serine·HCl;O-Methyl-D-serine,97%;O-Methyl-D-Ser hydrochloride;D-O-methylserine Hydrochlorate
- CBNumber
- CB31479718
- Molecular Formula
- C4H9NO3
- Formula Weight
- 119.12
- MOL File
- 86118-11-8.mol
(R)-2-Amino-3-methoxylpropanoic acid Property
- Boiling point:
- 260.6±30.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.10±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C4H9NO3/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1
- InChIKey
- KNTFCRCCPLEUQZ-GSVOUGTGSA-N
- SMILES
- C(O)(=O)[C@@H](COC)N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A613330
- Product name
- (R)-2-Amino-3-methoxypropanoicacid
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- A613330
- Product name
- (R)-2-Amino-3-methoxypropanoicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FA154540
- Product name
- (R)-2-Amino-3-methoxypropanoic acid
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CCH0004327
- Product name
- (R)-2-AMINO-3-METHOXYLPROPANOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $240.45
- Updated
- 2021/12/16
- Product number
- FA154540
- Product name
- (R)-2-Amino-3-methoxypropanoic acid
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
(R)-2-Amino-3-methoxylpropanoic acid Chemical Properties,Usage,Production
Uses
(R)-2-amino-3-methoxypropionic acid belongs to O-methyl-D-serine, is a non-natural amino acid, and is the main intermediate in the synthesis of lacoamide. It has been widely used in pharmaceutical and other industries.
Synthesis
98026-05-2
4219-94-7
The general procedure for the synthesis of O-methyl DL-serine from 2-amino-3-methoxypropionamide was as follows: in small-scale experiments, ACL racemase (Locus: E01594) and PepB (Locus: D84499) were added to an aqueous solution containing α-amino-β-methoxypropionamide (4). The reaction mixture (20 mL) contained 2 mM pyridoxal 5'-phosphate (PLP), 0.1 M potassium phosphate buffer (KPB, pH 9.0), and 0.5 mol/L α-amino-β-methoxypropionamide (4). Subsequently, ACL racemization enzyme (3.0 mg) and PepB (1.2 mg) were added, and the reaction was incubated for 18 h at 38°C. The progress of the reaction was monitored by periodic sampling. D/L-α-amino-β-methoxyalanamide (4) and O-methyl-L-serine (5) were determined using HPLC equipped with a Crownpak CR(+) column at a flow rate of 0.5 mL/min employing 50 mM HClO4 as a solvent system, and the absorbance of the eluate was monitored at 210 nm. Upon completion of the reaction, O-methyl-L-serine (5) was obtained by deproteinization with trichloroacetic acid and separation by Dowex-X8 (H+) column chromatography. The isolated O-methyl-L-serine (5) (7.98 mmol, 950 mg) was recrystallized from a mixed solvent of water-methanol-isopropanol-ether to give white crystals with an enol purity of >99.9%. The product has a melting point of 211-213 °C (decomposition) and a specific rotation of 1/25D (c 1, 6 mol/L HCl).1H NMR (400 MHz, D2O) data: δ 3.24 (s, 3H), 3.78-3.81 (m, 1H), 3.83 (dd, J = 3.5, 9.8 Hz, 1H), 4.01 (dd, J = 6.1, 9.8 Hz, 1H).13C NMR (100 MHz, D2O) data: δ 177.3 (CO), 76.5 (CH2), 60.2 (CH), 56.7 (OCH3). Elemental analysis (C4H9NO3) Calculated values: C, 40.32; H, 7.58; N, 11.75. Measured values: C, 40.35; H, 7.54; N, 11.77. ESI-MS (m/z): 120.1230 [M + H]+.
References
[1] Tetrahedron Asymmetry, 2012, vol. 23, # 24, p. 1653 - 1656
(R)-2-Amino-3-methoxylpropanoic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from (R)-2-Amino-3-methoxylpropanoic acid manufacturers
- Product
- (R)-2-Amino-3-methoxylpropanoic acid 86118-11-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2018-08-09