2-Thiopheneacetyl chloride

Product Name: 2-Thiopheneacetyl chloride
CAS No.: 39098-97-0
Chemical Name: 2-Thiopheneacetyl chloride
Synonyms: SKL1309;AKOS BBS-00003919;2-ThiopheneacetyL;TIMTEC-BB SBB006705;2-Thiopheneacetyl ch;Articaine Impurity 2;Articaine Impurity 11;2-thiophenyl chloride;2-THIENYLACETYL CHLORIDE;Articaine Impurities1823
CBNumber: CB3152140
Molecular Formula: C6H5ClOS
Formula Weight: 160.62
MOL File: 39098-97-0.mol

More

Less

2-Thiopheneacetyl chloride Property

Boiling point:: 105-106 °C/22 mmHg (lit.) 130-135 °C/90 mmHg (lit.)
Density: 1.303 g/mL at 25 °C (lit.)
vapor pressure: 4 mm Hg ( 83 °C)
refractive index: n20/D 1.551(lit.)
Flash point:: 215 °F
storage temp.: 2-8°C
form: Liquid
color: Clear brown
Specific Gravity: 1.303
Water Solubility: Reacts with water.
Sensitive: Moisture Sensitive
BRN: 114547
InChIKey: AJYXPNIENRLELY-UHFFFAOYSA-N
CAS DataBase Reference: 39098-97-0(CAS DataBase Reference)
EPA Substance Registry System: 2-Thiopheneacetyl chloride (39098-97-0)

More

Less

Safety

Hazard Codes: C
Risk Statements: 14-34-37-29
Safety Statements: 26-28-36/37/39-45-8-30-23
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 8-10-21
TSCA: T
HazardClass: 8
PackingGroup: III
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 195995
Product name: 2-Thiopheneacetyl chloride
Purity: 98%
Packaging: 25g
Price: $51.78
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.41865
Product name: Thiophene-2-acetyl chloride
Purity: for synthesis
Packaging: 25ML
Price: $225
Updated: 2022/05/15

TCI Chemical

Product number: T1751
Product name: Thiophene-2-acetyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: T1751
Product name: Thiophene-2-acetyl Chloride
Purity: >98.0%(GC)(T)
Packaging: 250g
Price: $469
Updated: 2024/03/01

Alfa Aesar

Product number: L09323
Product name: 2-Thiopheneacetyl chloride, 98%
Packaging: 25g
Price: $67.65
Updated: 2024/03/01

More

Less

2-Thiopheneacetyl chloride Chemical Properties,Usage,Production

Description

2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis of Nitrocefin (N493815), a chromogenic substrate that changes colour in the presence of β-lactamases and penicillin-binding proteins.

Chemical Properties

CLEAR BROWN LIQUID

Uses

2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.

Uses

2-Thiopheneacetyl chloride was used in the synthesis of:

(S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator
5-fluorouracil-cephalosporin prodrug
series of new N,N′-di(thiopheneacetyl)diamines derivatives
6-β-(thiophen-2′-yl)acetamidomorphine

General Description

A clear yellow to dark brown liquid. Insoluble in water and denser than water. Corrosive to skin, and eyes. Vapors severely irritate respiratory tract.

Air & Water Reactions

Insoluble in water. Decomposes exothermically in water yielding fumes of toxic hydrogen chloride.

Reactivity Profile

THIOPHENE-2-ACETYL CHLORIDE is incompatible with water, bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Synthesis

In the four-hole boiling flask with mechanical stirring, thermometer, air guide outlet, add 100g 2-thiophene acetic acid; 350g methylene dichloride, stirs and is warming up to 37 DEG C, starts to drip 250g sulfur oxychloride under the protection of nitrogen; within 1.5 hours, drip off insulation reaction 2.5 hours at this temperature.The methylene dichloride of underpressure distillation remnants, continues to distill obtaining 2-thiophen acetyl chloride 102.5g, and yield reaches 91.5%.

2-Thiopheneacetyl chloride Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot 2-Thiopheneacetic acid

Preparation Products

More

Less

2-Thiopheneacetyl chloride Suppliers

Belgium 2 Canada 1 China 402 Europe 1 Germany 5 India 10 Japan 3 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 31 Global 471

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Standardpharm Co. Ltd.

Tel: 86-714-3992388
Email: overseasales1@yongstandards.com
Country: United States
ProdList: 14332
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Wilshire Chemical Company Inc.

Tel: --
Fax: --
Email: WilshrChem@AOL.COM
Country: United States
ProdList: 3498
Advantage: 58

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

Alfa Aesar

Tel: --
Fax: --
Email: tech@alfa.com
Country: United States
ProdList: 6814
Advantage: 81

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Dishman Europe Ltd

Tel: --
Fax: --
Email: info@dishman-europe.com
Country: United States
ProdList: 622
Advantage: 58

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

AB Chem Technologies, LLC

Tel: --
Fax: --
Email: sales@abchemtech.com
Country: United States
ProdList: 1101
Advantage: 46

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

TimTec Corporation

Tel: --
Fax: --
Email: info@timtec.net
Country: United States
ProdList: 6891
Advantage: 68

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

More

Less

View Lastest Price from 2-Thiopheneacetyl chloride manufacturers

Great Innovation (Shanghai) Pharma Co., Ltd.,

Product: 2-Thiopheneacetyl chloride 39098-97-0
Price: US $68.00/Kg/Drum
Min. Order: 500KG
Purity: 98% and 99%
Supply Ability: 10,000kg per month
Release date: 2021-07-28

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Thiopheneacetyl chloride 39098-97-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Thiopheneacetyl chloride 39098-97-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-07

39098-97-0, 2-Thiopheneacetyl chlorideRelated Search:

2-Thiazolecarboxamidine Hydrochloride 2-Thiophenecarboxylic acid 2-Thiophenecarboxaldehyde 2-Thiophenesulfonyl chloride Thiophene-2-sulfonamide 2-Thiopheneacetic acid Acetyl chloride 2-Thiopheneacetyl chloride 2-Ethylthiophene Methyl 3-amino-4-methylthiophene-2-carboxylate 4-Thien-2-yltetrahydro-2H-pyran-4-carbonyl chloride 97% ARTICAINE IMPURITY A Articaine hydrochloride ARTICAINE IMPURITY E Articaine IMpurity G (Butylarticaine HCl) methyl 3-(2-bromopropanoylamino)-4-methyl-thiophene-2-carboxylate 2-Thiopheneacetyl chloride, alpha-oxo- (9CI) 2-Thiopheneacetyl chloride, 3-chloro-alpha-oxo- (9CI)

TIMTEC-BB SBB006705

THIOPHENE-2-ACETYL CHLORIDE

2-Thiopheneacethylchloride

2-THIOPHENE ACETYL CHLORIDE (TAC)

2-(2-THIENYL)ACETYL CHLORIDE

2-THIOPHENEACETYL CHLORIDE

2-THIENYLACETYL CHLORIDE

2-Thienylacetic acid chloride

AKOS BBS-00003919

2-Thiopheneacetic acid, chloride

thiophene-2-acetyl chloride(corrosive liquids,n.o.s.)

2-THIOPHENEACETYL CHLORIDE 98+%

2-THIOPHENEACETYL CHLORIDE 98.5%

2-Thiopheneacetyl ch

2-Thiopheneacetyl chloride, 99% 5GR

Thien-2-ylacetyl chloride

Thiophene-2-acetic acid chloride

2-Thiopheneacetyl chloride,99%

2-Thophene Acetyl Chloride

(Thien-2-yl)acetyl chloride 98%

2-(Thien-2-yl)ethanoyl chloride, 2-(2-Chloro-2-oxoethyl)thiophene

2-Thiopheneacetyl chloride 98%

sn-(3-oleoyl-2-hydroxy)-glycerol-1-phospho-sn-3'-(1',2'-dioleoyl)-glycerol

Appearance White crystalline powder Content 99 Melting point 153-156 Specific Rotation -16-19

2-ThiopheneacetyL

2-Thiopheneacetyl chloride in stock Factory

Thiophene acetyl chloride

Articaine Impurity 11

2-Thiopheneacetyl chloride ISO 9001：2015 REACH

SKL1309

Thiophene2-acetyl chloride-98%

Articaine Impurities1823

Articaine Impurity 2

2-Thiopheneacetyl chloride (6CI, 7CI, 9CI, ACI)

Articaine Impurity 11 CRS

2-thiophenyl chloride

39098-97-0

39087-97-0

C5H3OClS

C6H6ClOS

Building Blocks

Thiophenes

Heterocyclic Building Blocks

Thiophene&Benzothiophene

bc0001