5-Bromophthalide
- Product Name
- 5-Bromophthalide
- CAS No.
- 64169-34-2
- Chemical Name
- 5-Bromophthalide
- Synonyms
- 5-bromoisobenzofuran-1(3H)-one;5-broMo-1,3-dihydro-2-benzofuran-1-one;ROXA-024;5-BromophthaL;5-Bromophthali;5-BROMOPHTHALIDE;5-Bromophathalide;5-Bromophthalide,98%;5-Bromophthalide 97%;5-Bromophthalide >
- CBNumber
- CB3157943
- Molecular Formula
- C8H5BrO2
- Formula Weight
- 213.03
- MOL File
- 64169-34-2.mol
5-Bromophthalide Property
- Melting point:
- 162-166 °C(lit.)
- Boiling point:
- 377.7±42.0 °C(Predicted)
- Density
- 1.742±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in acetone.
- form
- Crystalline Powder
- color
- Beige to light yellow
- InChI
- InChI=1S/C8H5BrO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3H,4H2
- InChIKey
- IUSPXLCLQIZFHL-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(Br)C=C2)CO1
- CAS DataBase Reference
- 64169-34-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 647187
- Product name
- 5-Bromophthalide
- Purity
- 97%
- Packaging
- 5g
- Price
- $29.97
- Updated
- 2025/07/31
- Product number
- 647187
- Product name
- 5-Bromophthalide
- Purity
- 97%
- Packaging
- 25g
- Price
- $79.1
- Updated
- 2025/07/31
- Product number
- B2770
- Product name
- 5-Bromophthalide
- Packaging
- 5G
- Price
- $31
- Updated
- 2025/07/31
- Product number
- B2770
- Product name
- 5-Bromophthalide
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $94
- Updated
- 2025/07/31
- Product number
- B686570
- Product name
- 5-Bromophthalide
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
5-Bromophthalide Chemical Properties,Usage,Production
Chemical Properties
5-Bromophthalide is white to Pale Yellow Crystalline Solid
Uses
5-Bromophthalide is a useful synthetic intermediate
Uses
5-Bromophthalide is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. It is a key intermediate of citalopram.
Synthesis
65399-05-5
64169-34-2
The general procedure for the synthesis of 5-bromophthalide from 5-aminophthalide was as follows: first, 5-nitrophthalimide (8) was prepared by nitration of phthalimide (7), using 200 g of phthalimide (7) in a mixture of HNO3 and H2SO4 acids at 0 °C to give 146 g of the product (8) in 56% yield. Subsequently, 8 was reduced to amine 9 by catalytic hydrogenation, using 5% Pd/C as catalyst, in EtOAc solvent in 97% yield. This step encountered the bottleneck of high solvent usage in large-scale operation. The improved method used the catalytic reduction reaction of zinc powder and copper(II) sulfate in 6 M NaOH aqueous solution to prepare aminophthalide 10 directly from 8 in one step in 100% yield, which effectively solved the bottleneck problem. Aminophthalide 10 was converted to 5-bromophthalide 11 in 76% yield by the Sandmeyer reaction in the presence of NaNO2 and 4 M HBr at 0 °C, followed by the addition of CuBr. A single batch yielded 36 g of 11. Next, 11 was reduced by diisobutylaluminum hydride (DIBAL) in toluene at -42 °C to give bromolactone 12 in 77% yield . Finally, 12 was reacted with boron trifluoride ether compounds in methanol to prepare bromoacetal 6 in 96% yield. The whole synthetic route was efficient and only the last two steps (e and f) required purification of the product by chromatography.
References
[1] Patent: US2011/77394, 2011, A1. Location in patent: Page/Page column 15
[2] Patent: CN108383833, 2018, A. Location in patent: Paragraph 0013
[3] Journal of the Chemical Society, 1931, p. 867,869
[4] Journal of Heterocyclic Chemistry, 2006, vol. 43, # 5, p. 1195 - 1204
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 5, p. 1941 - 1946
5-Bromophthalide Preparation Products And Raw materials
Raw materials
Preparation Products
5-Bromophthalide Suppliers
- Tel
- 0517-83187139 18205232085
- cai@jiamu-bio.com
- Country
- China
- ProdList
- 2996
- Advantage
- 58
- Tel
- 18072995930
- sales001@hongdabova.com
- Country
- China
- ProdList
- 25
- Advantage
- 58
- Tel
- 18625279558; 18625279558
- sales01@junchpharm.com
- Country
- China
- ProdList
- 12
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 0512-68323967 18015559028
- Fax
- +86-512-69200360
- sales@iticmedchem.com
- Country
- China
- ProdList
- 506
- Advantage
- 61
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2338
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 010-60275820 13031183356
- Fax
- 010-60270825
- elainezt@sina.com
- Country
- China
- ProdList
- 1390
- Advantage
- 62
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0512-69209928 18796809688
- Fax
- 0512-68417696
- zhouyingxiang@highfine.com
- Country
- China
- ProdList
- 475
- Advantage
- 75
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16077
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- +86 (573) 82222445 (0)18006601000 452520369
- Fax
- +86 (573) 82222643
- sales@maya-r.com
- Country
- China
- ProdList
- 11707
- Advantage
- 57
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3199
- Advantage
- 55
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 3997
- Advantage
- 55
- Tel
- 022-60116533 13207668525
- Fax
- 022-60979672
- saleskc@scipharmacn.com
- Country
- China
- ProdList
- 603
- Advantage
- 58
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6134
- Advantage
- 55
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 021-02136680027 15800370750
- 1706640024@qq.com
- Country
- China
- ProdList
- 570
- Advantage
- 56
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 22514
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- 1822-2954721 15901640172
- Fax
- 0731-57805668
- sales03@hn-furui.com
- Country
- China
- ProdList
- 421
- Advantage
- 55
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 021-68367562 15002147577;
- Fax
- 021-68369562
- sales@haoyunchem.com
- Country
- China
- ProdList
- 457
- Advantage
- 55
- Tel
- 020-81960175
- Fax
- +1-541-2553641
- min.he@cato-chem.com
- Country
- China
- ProdList
- 1955
- Advantage
- 55
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 010-51268198
- Fax
- 010-63833209
- leadershipchem@126.com
- Country
- China
- ProdList
- 2546
- Advantage
- 58
- Tel
- 021-57340939 18017297327
- Fax
- 021-37210791
- sales@gaolangchemical.com
- Country
- China
- ProdList
- 892
- Advantage
- 55
- Tel
- 021-021-56795766
- Fax
- +86-21-56795266
- sales@worldyachem.com
- Country
- China
- ProdList
- 9476
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 021-58957966 18930537195
- Fax
- 021-60899437
- wouchina@126.com
- Country
- China
- ProdList
- 3027
- Advantage
- 58
- Tel
- 400-1166-196 13458535857
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 13350
- Advantage
- 58
View Lastest Price from 5-Bromophthalide manufacturers
- Product
- 5-Bromophthalide 64169-34-2
- Price
- US $0.00-0.00/g
- Min. Order
- 0.001g
- Purity
- 0.99
- Supply Ability
- 1 tons
- Release date
- 2024-11-15
- Product
- 5-Bromophthalide 64169-34-2
- Price
- US $400.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KG
- Release date
- 2020-10-24
- Product
- 5-Bromophthalide 64169-34-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20