Diethyl ethoxymethylenemalonate

Product Name: Diethyl ethoxymethylenemalonate
CAS No.: 87-13-8
Chemical Name: Diethyl ethoxymethylenemalonate
Synonyms: EMME;Diethyl 2-(ethoxymethylene)malonate;Diethyl 2-(ethoxymethylene)propanedioate;DEEMM;ETHOXYMETHYLENEMALONIC ACID DIETHYL ESTER;onate;2-Ethoxymethylene-malonic acid diethyl ester;tl1483;enemaL;NSC 9068
CBNumber: CB3163908
Molecular Formula: C10H16O5
Formula Weight: 216.23
MOL File: 87-13-8.mol

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Diethyl ethoxymethylenemalonate Property

Melting point:: -33°C
Boiling point:: 279-283 °C(lit.)
Density: 1.080 g/mL at 20 °C(lit.)
vapor pressure: <0.1 hPa
refractive index: n20/D 1.463
Flash point:: 311 °F
storage temp.: Store below +30°C.
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Liquid
color: Clear colorless to light yellow
Water Solubility: insoluble
BRN: 880058
InChIKey: LTMHNWPUDSTBKD-UHFFFAOYSA-N
LogP: 1.5-2.1 at pH7
CAS DataBase Reference: 87-13-8(CAS DataBase Reference)
NIST Chemistry Reference: Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8)
EPA Substance Registry System: Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-42/43
Safety Statements: 26-36/37/39-27-24/25
WGK Germany: 1
RTECS: OO1100000
Autoignition Temperature: 215 °C
TSCA: Yes
HS Code: 29189090
Toxicity: LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001792
Product name: Nalidixic acid impurity C
Purity: EuropePharmacopoeia (EP) Reference Standard
Packaging: Y0001792
Price: $204
Updated: 2022/05/15

Sigma-Aldrich

Product number: 05689
Product name: Diethyl ethoxymethylenemalonate
Purity: for LC-MS derivatization, ≥98.0% (GC)
Packaging: 1ml
Price: $31
Updated: 2022/05/15

TCI Chemical

Product number: E0255
Product name: Diethyl Ethoxymethylenemalonate
Purity: >98.0%(GC)
Packaging: 25mL
Price: $21
Updated: 2024/03/01

TCI Chemical

Product number: E0255
Product name: Diethyl Ethoxymethylenemalonate
Purity: >98.0%(GC)
Packaging: 100mL
Price: $40
Updated: 2024/03/01

Alfa Aesar

Product number: A13776
Product name: Diethyl ethoxymethylenemalonate, 98+%
Packaging: 50g
Price: $22.65
Updated: 2024/03/01

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Diethyl ethoxymethylenemalonate Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic.

Safety Profile

Moderately toxic by ingestion. A skin irritant. A combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Likely impurity is diethyl diethoxymethylene malonate which is difficult to separate from diethyl ethoxymethylene malonate by distillation, and it is necessary to follow the course of the distillation by the change in refractive index instead of boiling point. After a low boiling fraction is collected, there is obtained an intermediate fraction (n 20 1.414—1.458), the size of which depends on the amount of the diethoxymethylene compound. This fraction is fractionated through a 5inch Vigreux column (p 11) at low pressure avoiding interruption in heating. Fraction b 108-110o/0.25mm is ca 10o lower than the submitters' fraction (b 97.2o/0.25mm, n D 1.4612—1.4623) [Org Synth Coll Vol III 395 1955, Fuson et al. J Org Chem 11 197 1946, Duff & Kendal J Chem Soc 893 1948]. [Beilstein 3 IV 1192.]

Diethyl ethoxymethylenemalonate Preparation Products And Raw materials

Raw materials

Triethyl orthoformate Diethyl malonate

Preparation Products

Nalidixic acid Fleroxacin 7-(TRIFLUOROMETHYL)-4-QUINOLINOL 7-BROMO-3,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID Norfloxacin Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Alachlor ETHYL 4-CHLORO-3-METHYLTHIENO[2,3-B]PYRIDINE-5-CARBOXYLATE Lomefloxacin 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one 6-CHLORO-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE 3,4-DIHYDRO-8-HYDROXY-4-OXOQUINOLINE-3-CARBOXYLIC ACID Levofloxacin 4-HYDROXY-7-TRIFLUOROMETHYL-3-QUINOLINECARBOXYLIC ACID Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate Ethyl 4-hydroxy-2-phenylpyrimidine-5-carboxylate Orotic acid Ethyl 7-bromo-3,4-dihydro-4-oxoquinoline-3-carboxylate ,97% 4-HYDROXY-8-METHOXYQUINOLINE-3-CARBOXYLIC ACID Decoquinate 4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL 4-CHLOROTHIENO[2,3-B]PYRIDINE-5-CARBOXYLATE 1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER 4-HYDROXY-2-PHENYL-5-PYRIMIDINECARBOXYLIC ACID ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 4-HYDROXY-2-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER 4-HYDROXY-8-METHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER ETHYL 4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE-3-CARBOXYLATE 7-TRIFLUOROMETHYL-4-QUINOLINETHIOL

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View Lastest Price from Diethyl ethoxymethylenemalonate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Diethyl ethoxymethylenemalonate 87-13-8
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000
Release date: 2024-05-11

Baoji Guokang Bio-Technology Co., Ltd.

Product: Diethyl ethoxymethylenemalonate 87-13-8
Price: US $6.30/KG
Min. Order: 200Kg/Drum
Purity: 98%
Supply Ability: 100T
Release date: 2021-06-02

Hebei Yanxi Chemical Co., Ltd.

Product: Diethyl ethoxymethylenemalonate 87-13-8
Price: US $50.00-8.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-06

87-13-8, Diethyl ethoxymethylenemalonate Related Search:

Diethyl phthalate Diethyl fluoromalonate acetic acid, triethoxy-, ethyl ester Ethyl malonyl chloride Diethyl malonate Diethyl carbonate Diethyl ketomalonate Diethyl methylmalonate Mefenpyr-diethyl 2-AMINODIETHYLMALONATE Tris(trimethylsilyl)phosphate Diethyl benzylmalonate DIETHYL BROMOMALONATE ETHOXYLATED COCOAMINE (LATEX STABILIZER) Ethoxymethylenemalononitrile Ethyl(ethoxymethylene)cyanoacetate Isobornyl acrylate Sodium erythorbate

1,1-DICARBETHOXY-2-ETHOXYETHYLENE

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AKOS BBS-00004230

LABOTEST-BB LT02094814

ETHYL A-CARBETHOXY-B-ETHOXYACRYLATE

ETHYL ETHOXYMETHYLENE MALONATE

ETHYL 3-ETHOXY-2-(ETHOXYCARBONYL)ACRYLATE

EMME

ETHOXYMETHYLENEMALONIC ACID DIETHYL ESTER

(Ethoxymethylene)-propanedioic acid diethyl ester

ETHOXYMETHYLENMALONIC ACID DIETHYL ESTER

DIETHYL ETHOXYMETHYLENEMALONATE

Ethoxy Methylene Methyl Ester (EMME)

2-(EthoxyMethylene)propanedioic Acid 1,3-Diethyl Ester

Diethyl[(ethyloxy)Methylidene]propanedioate

Ethyl 3-Ethoxy-2-(ethoxyMethylene)-3-oxopropanoate

NSC 62117

NSC 9068

DIETHYL ETHOXYMETHYLENEMALONATE FOR SYNT

(ethoxymethylene)-malonicacidiethylester

(ethoxymethylene)-propanedioicacidiethylester

Diethyl 2-(ethoxymethylene)malonate

diethylemme

ethoxymethylenemalonicacid,ethylester

Malonic acid, (ethoxymethylene)-, diethyl ester

Propanedioicacid,(ethoxymethylene)-,diethylester

tl1483

Diethyl ethoxyMethyleneMalonate, 99+% 100GR

Diethyl ethoxyMethyleneMalonate, 99+% 500GR

Propanedioic acid, 2-(ethoxyMethylene)-, 1,3-diethyl ester

Diethyl ethoxyMethyleneMalonate 99%

Ethoxy Methylene

DEEMM

NALIDIXIC ACID IMPURITY C

Diethyl ethoxymethylenemalonate CAS NO.87-13-8

enemaL

onate

Ethoxymethylene Malonate Ester

Diethylethoxmethylenemalonate

Diethyl ethoxymethylenemalonate, 98+%

Ethyl α-carbethoxy-β-ethoxy acrylate

Diethyl ethoxymethylenemalonate, 99+%

ETHOXYMETHYLENE MALONIC ESTER(EMME)

ETHOXYMETHYLENEMALONICACIDDIETHYLESTER(E.M.M.E)

Diethylethoxymethylenmalonat

Ethoxy Diethyl Methylene Malonate

2-Ethoxymethylene-malonic acid diethyl ester

2-Ethoxy-1,1-bis(ethoxycarbonyl)ethene

Diethyl 2-(ethoxymethylidene)propanedioate

1,1-Di(ethoxycarbonyl)-2-ethoxyethene

1,1-Dicarboethoxy-2-ethoxyethylene

Diethyl ethoxymethyl

Diethyl Ethoxymethylidenemalonate

3-chloro-4-fluorotrifluoromethylene

Nalidixic acid impurity C CRS

DiethylEthoxymethylenemalonate&gt

Nalidixic Acid EP Impurity C

Diethyl 2-(ethoxymethylene)propanedioate