ChemicalBook > CAS DataBase List > p-Toluenesulfonic acid monohydrate

p-Toluenesulfonic acid monohydrate

Product Name
p-Toluenesulfonic acid monohydrate
CAS No.
6192-52-5
Chemical Name
p-Toluenesulfonic acid monohydrate
Synonyms
PTSA;TOLUENE-4-SULFONIC ACID;PTX;PTSA.H2O;4-Methylbenzenesulfonic acid hydrate;TOLUENESULFONIC ACID MONOHYDRATE;PARA TOLUENE SULFONIC ACID;p-Toluenesulfonic acid hydrate;4-TOLUENESULFONIC ACID MONOHYDRATE;PTSA Monohydrate
CBNumber
CB3173385
Molecular Formula
C7H10O4S
Formula Weight
190.22
MOL File
6192-52-5.mol
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p-Toluenesulfonic acid monohydrate Property

Melting point:
96-99 °C(lit.)
Boiling point:
140°C 20mm
Density 
1,24 g/cm3
vapor density 
5.9 (vs air)
refractive index 
1,382-1,384
Flash point:
180 °C
storage temp. 
Store at +5°C to +30°C.
solubility 
H2O: 0.1 g/mL, clear
form 
Solid
Colour Index 
42655
color 
White to pink
PH
1 (650g/l, H2O, 20℃)(anhydrous substance)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,9533
BRN 
3568023
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases, most common metals. Protect from moisture.
InChIKey
KJIFKLIQANRMOU-UHFFFAOYSA-N
CAS DataBase Reference
6192-52-5(CAS DataBase Reference)
EPA Substance Registry System
Benzenesulfonic acid, 4-methyl-, monohydrate (6192-52-5)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38-34-37
Safety Statements 
26-37-45-36/37/39
RIDADR 
UN 2585 8/PG 3
WGK Germany 
-
RTECS 
XT6300000
F 
3
Autoignition Temperature
600 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29041000
Toxicity
LD50 orally in Rabbit: 2570 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
TX0770
Product name
p-Toluenesulfonic Acid, Monohydrate
Purity
GR ACS
Packaging
500g
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14725
Product name
Toluene-4-sulfonic acid monohydrate
Purity
for synthesis
Packaging
100g
Price
$28.6
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14725
Product name
Toluene-4-sulfonic acid monohydrate
Purity
for synthesis
Packaging
1kg
Price
$75
Updated
2024/03/01
Sigma-Aldrich
Product number
8.14725
Product name
Toluene-4-sulfonic acid monohydrate
Purity
for synthesis
Packaging
5kg
Price
$264
Updated
2024/03/01
Sigma-Aldrich
Product number
27815
Product name
p-Toluenesulfonic acid monohydrate
Purity
≥99% (calc. to H2O free subst.)
Packaging
1kg
Price
$62.5
Updated
2024/03/01
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p-Toluenesulfonic acid monohydrate Chemical Properties,Usage,Production

Chemical Properties

White crystals

Uses

Derivitizing agent.

Uses

p-Toluenesulfonic acid monohydrate is used as a catalyst in the synthesis of resveratrol, in oxane derivatives as an antimalarial agent, as substituted piperidine and unsymmetrical benzyl. It acts as a catalyst in the preparation of 1,3,5-trisubstituted pyrazoles derivatives, selenated ketene dithioacetals, triazoloquinazolinone and benzimidazoquinazolinone derivatives. It also serves as an intermediate in the esterification and in reductive amination reactions.

Uses

p-Toluenesulfonic acid monohydrate (p-TsOH·H2O) may be used as a catalyst in the synthesis of the following:

  • Unsymmetrical benzils.
  • Highly substituted piperidines.
  • 1,3,5-Trisubstituted benzenes by trimerization of alkynes.
  • Triazoloquinazolinone and benzimidazoquinazolinone derivatives.
  • 1,3,5-Trisubstituted pyrazoles derivatives.
  • Selenated ketene dithioacetals.

General Description

p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with P21/c space group. Its solubility in aqueous sulfuric acid solutions has been studied.

Purification Methods

Purify the acid by precipitation from a saturated solution at 0o by introducing HCl gas. It can also be crystallised from conc HCl, then crystallised from dilute HCl (charcoal) to remove benzenesulfonic acid. It has been crystallised from EtOH/water. Dry it in a vacuum desiccator over solid KOH and CaCl2. p-Toluenesulfonic acid can be dehydrated by azeotropic distillation with *benzene or by heating at 100o for 4hours under water-pump vacuum. The anhydrous acid can be crystallised from *benzene, CHCl3, ethyl acetate, anhydrous MeOH, or from acetone by adding a large excess of *benzene. It can also be dried under vacuum at 50o. The S-benzylisothiuronium salt has m 182o (from aqueous EtOH). [Beilstein 11 IV 241.]

p-Toluenesulfonic acid monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE Pyridinium p-Toluenesulfonate Methyl glycolate Ethyl (R)-2-hydroxy-4-phenylbutyrate Saquinavir LENAMPICILLIN 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID Clemizole Doxifluridine 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Cefoperazone 4-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,3-THIADIAZOL-5-AMINE 4-PYRIDINEETHANETHIOL HYDROCHLORIDE 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE 4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE 2-(3-CHLOROPROPYL)-1,3-DIOXOLANE METHYL 4-BROMO-3-OXOPENTANOATE 3-METHOXYCARBONYL-3-SULFOLENE 2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID 4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE 4-(4-CHLOROPHENYL)-1,2,3-THIADIAZOL-5-AMINE 2-Phenyl-2-imidazoline
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View Lastest Price from p-Toluenesulfonic acid monohydrate manufacturers

Hebei Dangtong Import and export Co LTD
Product
p-Toluenesulfonic acid monohydrate 6192-52-5
Price
US $4020.00-4000.00/tons
Min. Order
10tons
Purity
99%
Supply Ability
1000tons
Release date
2023-02-17
airuikechemical co., ltd.
Product
P-Toluenesulfonic Acid Monohydrate 6192-52-5
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.99%
Supply Ability
2000 tons
Release date
2024-04-10
Henan Fengda Chemical Co., Ltd
Product
p-Toluenesulfonic acid monohydrate 6192-52-5
Price
US $158.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-05

6192-52-5, p-Toluenesulfonic acid monohydrateRelated Search:

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